Anemia Etiology Evaluation in Ethiopia (AnemEE)

Evaluation of Dietary Iron Intake, Anemia, and Iron Status Among Men, Women, and Children in Ethiopia

The AnemEE study is a population-based anemia etiology survey in six regions of Ethiopia. The primary aim of the study is to evaluate the relative contribution of risk factors for anemia among children, women of reproductive age, and adult men. The study data are intended to inform evidence-based decision-making on anemia control interventions.

Study Overview

• Status: Completed
• Conditions: Anemia
• Intervention / Treatment: Other: Risk factors for anemia

Detailed Description

The AnemEE study is a population-based cross-sectional survey of children (6-59 months), adult women of reproductive age (15-49 years) and adult males (15-49 years) in six regions of Ethiopia (Afar, Amhara, Tigray, Oromia, Southern Nations, Nationalities and Peoples' Region and Addis Ababa). The study will enroll approximately 5,100 participants and will be conducted in two survey rounds; one survey round in the Belg season and one survey round in the Meher season. All participants will have hemoglobin assessed and will have standardized questionnaires administered to assess sociodemographic, diet, morbidity, and other health/nutrition factors. All participants will also have assessments of anthropometric measures, malaria, and soil transmitted helminth infection. A subset of participants will also have serum ferritin, CRP, AGP, vitamin B12, and folate concentrations assessed. The study data will be used to determine the relative contributions of risk factors for anemia.

• Study Type: Observational
• Enrollment (Actual): 5114

Contacts and Locations

Study Locations

• Ethiopia
  • Addis Ababa, Ethiopia
    • Addis Continental Institute of Public Health

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 6 months to 48 years (Child, Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Children (6-59 months); Women of reproductive age (15-49 years); Adult men (15-49 years)

Description

Inclusion Criteria:

1. Women of reproductive age

   • Female living in a selected household that has a woman 15-49 years of age
   • Aged 15-49 years

2. Adult Men

   • Male living in a selected household that has a woman 15-49 years of age
   • Aged 15-49 years

3. Children

   • Male or female child living in a selected household that has a woman 15-49 years of age
   • Aged 6-59 months

Exclusion Criteria:

• Does not provide informed consent

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Children (6-59 months)	Other: Risk factors for anemia; Diet, iron, vitamin B12, folate, inflammation, soil transmitted helminth infection, malaria, other morbidities and other health/nutrition/sociodemographic factors
Women of Reproductive Age (15-49 years)	Other: Risk factors for anemia; Diet, iron, vitamin B12, folate, inflammation, soil transmitted helminth infection, malaria, other morbidities and other health/nutrition/sociodemographic factors
Adult Men (15-49 years)	Other: Risk factors for anemia; Diet, iron, vitamin B12, folate, inflammation, soil transmitted helminth infection, malaria, other morbidities and other health/nutrition/sociodemographic factors

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anemia	Hemoglobin concentration by sex and age (<11 g/dL for children; Hb <12 g/dL for non-pregnant adult women, <13 g/dL for adult men). Hemoglobin concentrations will be adjusted for altitude and smoking status.	One day

Collaborators and Investigators

• Sponsor: Harvard School of Public Health (HSPH)
• Collaborators: Addis Continental Institute of Public Health
• Investigators: Principal Investigator: Wafaie W Fawzi, MBBS, DrPH, Harvard School of Public Health (HSPH)

Publications and helpful links

General Publications

• Tadesse AW, Hemler EC, Andersen C, Passarelli S, Worku A, Sudfeld CR, Berhane Y, Fawzi WW. Anemia prevalence and etiology among women, men, and children in Ethiopia: a study protocol for a national population-based survey. BMC Public Health. 2019 Oct 24;19(1):1369. doi: 10.1186/s12889-019-7647-7.

Study record dates

Study Major Dates

• Study Start (Actual): January 27, 2019
• Primary Completion (Actual): August 15, 2019
• Study Completion (Actual): August 15, 2019

Study Registration Dates

• First Submitted: June 21, 2019
• First Submitted That Met QC Criteria: June 27, 2019
• First Posted (Actual): June 28, 2019

Study Record Updates

• Last Update Posted (Actual): July 28, 2020
• Last Update Submitted That Met QC Criteria: July 27, 2020
• Last Verified: July 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Hematologic Diseases; Anemia
• Other Study ID Numbers: OPP1179606

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No