Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool (METABIOM)
Characterization and Comparison of the Human Microbiome in Peritoneum, Jejunum, Rectum and Stool
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum.
The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall.
Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Homburg/Saar, Germany, D-66421
- Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- abdominal surgery containing opening of jejunum
- singing of consent
Exclusion Criteria:
- inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
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Patients
Subjects to undergo surgery including opening of the jejunum with non-inflammative condition.
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Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
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Characterization of microbiome
Time Frame: intra-operative
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Previously uncharacterized sites: jejunum, peritoneum
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intra-operative
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Michael Jelden, Dr., Saarland University Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- METABIOM
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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