Laser Therapy on Orthodontic Tooth Movement

The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Study Overview

• Status: Completed
• Conditions: Laser Therapy; Bone Remodeling; Orthodontic Tooth Movement
• Intervention / Treatment: Device: Low-level Laser Therapy; Procedure: Orthodontic force

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • MG
    • Belo Horizonte, MG, Brazil, 30535-901
      • Pontifical Catholic University of Minas Gerais

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 13 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Facial convexity
• Protrusion or biprotrusion of the incisors
• Dental crowding
• Healthy periodontal condition
• Satisfactory oral hygiene

Exclusion Criteria:

• Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months
• Skeletal crossbite
• Parafunctional habits
• Occlusal interference

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

5

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Low-level laser therapy and no orthodontic force; No orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours	Device: Low-level Laser Therapy; Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons
Experimental: Low-level laser therapy and application of orthodontic force; Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours	Device: Low-level Laser Therapy; Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons; Procedure: Orthodontic force; Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement
Active Comparator: Orthodontic force only; Orthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy	Procedure: Orthodontic force; Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement
Experimental: Low-level laser therapy and orthodontic force; Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated	Device: Low-level Laser Therapy; Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons; Procedure: Orthodontic force; Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement
Active Comparator: Orthodontic force with no laser therapy; Orthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy	Procedure: Orthodontic force; Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed before canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 1 month of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 2 months of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 3 months of canine retraction

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Chemokine levels in the periodontal tissue after LLLT and orthodontic force	The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)	The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy

Collaborators and Investigators

• Sponsor: Ildeu Andrade Jr.

Publications and helpful links

General Publications

• Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.
• Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.
• Torri S, Weber JB. Influence of low-level laser therapy on the rate of orthodontic movement: a literature review. Photomed Laser Surg. 2013 Sep;31(9):411-21. doi: 10.1089/pho.2013.3497. Epub 2013 Jul 24.
• Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013 Jan;28(1):41-7. doi: 10.1007/s10103-012-1059-6. Epub 2012 Feb 18.
• Kim SJ, Moon SU, Kang SG, Park YG. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009 Sep;41(7):524-33. doi: 10.1002/lsm.20792.

Study record dates

Study Major Dates

• Study Start (Actual): February 1, 2014
• Primary Completion (Actual): November 6, 2018
• Study Completion (Actual): September 16, 2019

Study Registration Dates

• First Submitted: August 15, 2019
• First Submitted That Met QC Criteria: August 24, 2019
• First Posted (Actual): August 28, 2019

Study Record Updates

• Last Update Posted (Actual): September 24, 2020
• Last Update Submitted That Met QC Criteria: September 16, 2020
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Keywords: Low-Level Light Therapy; Bone Remodeling; Tooth Movement
• Other Study ID Numbers: Laser on tooth movement

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes
• product manufactured in and exported from the U.S.: Yes