VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

April 12, 2021 updated by: Gul Yildiz Telatar, Recep Tayyip Erdogan University Training and Research Hospital

Association Between Enamel Gene Variants and Dental Caries in Adults

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

TFIP11 and VDR genes are related to enamel formation genes

Study Type

Observational

Enrollment (Actual)

160

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Rize, Turkey, 53000
        • Recep Tayyip Erdogan University Dentistry Faculty

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

24 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

160 adult in the 24-40 age range living in Northeast Turkey will allowed in the study

Description

Inclusion Criteria:

  • adult be between 24 and 40 years old
  • subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT>13.9

Exclusion Criteria:

  • systemic or genetic disorders
  • orthodontic appliances
  • pregnant women

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
high caries experience
80 adults will be allowed in the high caries experience group according to DMFT index DMFT>13.9
Genetic: high caries experience
DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit
Other Names:
  • DNA isolation, genotyping
low caries experience
80 adults will be allowed in the high caries experience group according toDMFT index DMFT≤4
Genetic: high caries experience
DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit
Other Names:
  • DNA isolation, genotyping

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
past caries experience
Time Frame: 3 weeks
Each tooth will be examined and recorded as decayed, missing, or filled
3 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Plaque index
Time Frame: 3 weeks
The plaque amount is scored by using Silness&Löe Plaque Index plaque index PI<1.0 healthy PI 1.1-2.0 mild PI>2 high plaque
3 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 26, 2019

Primary Completion (Actual)

January 26, 2020

Study Completion (Actual)

February 10, 2020

Study Registration Dates

First Submitted

October 10, 2019

First Submitted That Met QC Criteria

October 10, 2019

First Posted (Actual)

October 11, 2019

Study Record Updates

Last Update Posted (Actual)

April 15, 2021

Last Update Submitted That Met QC Criteria

April 12, 2021

Last Verified

April 1, 2021

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2019-204

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Data will be available within 6 months of study completion

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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