- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04218981
Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders
August 10, 2020 updated by: Guo Wenbin, Central South University
To explore the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of cross-sectional and longitudinal study designs, including a longitudinal study with 8 weeks of drugs treatment.
And explore whether there are shared imaging biomarkers between these three common mental disorders.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
Previous studies suggest that there are brain anatomical and functional abnormalities in patients with schizophrenia, bipolar disorder(BD), major depressive disorder(MDD), and the pathogenesis of these three mental disorders may exist overlaps.
However, it remains unclear whether these abnormalities can be used for the diagnosis and prediction of treatment effects in mental disorders.
It is also unclear whether there are shared imaging biomarkers between these three common mental disorders.
In a word, there still lacks reliable neuroimaging biomarkers in mental disorders.
Based on the previous studies, this study aims to examine the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of cross-sectional and longitudinal study designs, including a longitudinal study with 8 weeks of drugs treatment( schizophrenia patients are treated with one antipsychotic drug(olanzapine, risperidone; amisulpride); patients with bipolar disorder are treated with one mood stabilizer(lithium;valproate);patients with major depressive disorder are treated with paroxetine).
First, neuroimaging biomarkers are definitively selected in patients with different mental disorders for the purpose of diagnosis by using a cross-sectional design.
After that, a longitudinal study is conducted in patients after 8 weeks of drugs treatment to validate that the selected neuroimaging biomarkers can be used to predict treatment response of medication.
The definitively selected neuroimaging biomarkers are expected to be useful for the diagnosis and prediction of treatment effects in these three mental disorders; and therefore to be helpful for understanding the pathophysiology of mental disorders.
Study Type
Interventional
Enrollment (Anticipated)
200
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Wenbin Guo, professor
- Phone Number: 13875936768
- Email: guowenbin76@csu.edu.cn
Study Locations
-
-
-
Changsha, China
- Recruiting
- The Second Xiangya Hospital of Central South University
-
Contact:
- Wenbin Guo, professor
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 48 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Diagnostic criteria for schizophrenia,bipolar disorder, major depressive disorder according to the Structural Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)
- Never received any treatment before.
- For healthy controls: their first-degree relative had no history of psychiatric disorders.
Exclusion Criteria:
- The exclusion criteria for all subjects were as follows: any physical illnesses, such as liver, kidney, and cardiovascular diseases; any current or past neuropsychiatric disorders; any traumatic brain injury; seizures; serious impulsive behavior; drug or alcohol addiction; contraindications for MRI; and pregnancy.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Schizophrenia group
|
Choose one of these antipsychotics (olanzapine, risperidone; amisulpride) for schizophrenia group
Other Names:
|
Experimental: Bipolar disorder group
|
Choose lithium or valproate for bipolar disorder group
Other Names:
|
Experimental: Major depressive disorder group
|
Patients with major depressive disorder are treated with paroxetine
Other Names:
|
No Intervention: Healthy controls
MRI scan at baseline and no drugs treatment
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Resting-state functional magnetic resonance imaging (fMRI) data acquisition for all participants
Time Frame: 8 week
|
A 3.0 T Siemens scanner (Germany) was applied to obtain the MRI images in the Second Xiangya Hospital of Central South University.The MRI data will be obtained before and after treatment at different follow up point.All participants were told to lie on the scanner with their eyes closed.
They wore soundproof headphones and asked to remain still.
The parameters were as follows: repetition time of 2710 ms, echo time of 3.78 ms, flip angle of 7°, inversion time of 1000 ms, slice thickness of 1 mm, field of view of 256 mm × 256 mm, matrix of 256 × 256, no gap, and 188 slices.
|
8 week
|
Positive and Negative Syndrome Scale (PANSS)
Time Frame: 8 week
|
The PANSS total scores ,subscale scores were used to evaluate the severity of psychotic symptoms at baseline and eight weeks for schizophrenia.The total score of the PANSS was more than 60.The higher scores mean a worse outcome.
|
8 week
|
Hamilton Depression Scale-17 (HAMD-17)
Time Frame: 8 week
|
HAMD-17 total scores were used to evaluate the severity of depressive symptoms at baseline and eight weeks for major depressive disorder.
The total score of the HAMD-17 was more than 17.The higher scores mean a worse outcome.
|
8 week
|
Young Mania Rating Scale (YMRS)
Time Frame: 8 week
|
YMRS total scores were used to evaluate the severity of manic symptoms for bipolar disorder before and after treatment at different follow up point.The higher scores mean a worse outcome.
|
8 week
|
Brief Cognitive Assessment Tool for schizophrenia(B-CATS)
Time Frame: 8 week
|
The investigators will use the B-CATS scale to assess cognitive function before and after treatment at different follow up point.The higher scores mean a better outcome.
|
8 week
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Social Disability Screening Schedule(SDSS)
Time Frame: 8 week
|
The investigators will use the SDSS scale to assess social function before and after treatment at different follow up point.The higher scores mean a worse outcome.
|
8 week
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Wenbin Guo, the Second Xiangya Hospital, Central South University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 15, 2020
Primary Completion (Anticipated)
June 1, 2023
Study Completion (Anticipated)
December 1, 2023
Study Registration Dates
First Submitted
December 27, 2019
First Submitted That Met QC Criteria
January 2, 2020
First Posted (Actual)
January 6, 2020
Study Record Updates
Last Update Posted (Actual)
August 12, 2020
Last Update Submitted That Met QC Criteria
August 10, 2020
Last Verified
December 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Schizophrenia Spectrum and Other Psychotic Disorders
- Disease
- Psychotic Disorders
- Mental Disorders
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Enzyme Inhibitors
- Tranquilizing Agents
- Psychotropic Drugs
- Serotonin Uptake Inhibitors
- Neurotransmitter Uptake Inhibitors
- Membrane Transport Modulators
- Serotonin Agents
- Antidepressive Agents
- Cytochrome P-450 Enzyme Inhibitors
- Antidepressive Agents, Second-Generation
- Cytochrome P-450 CYP2D6 Inhibitors
- Paroxetine
- Antipsychotic Agents
Other Study ID Numbers
- 81771447
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Common Mental Disorder
-
The University of Hong KongRecruiting
-
New York State Psychiatric InstituteUniversity of Pennsylvania; Columbia UniversityRecruitingCommon Mental Disorders | Severe Mental DisorderMozambique
-
King's College LondonCompletedAlcohol Use Disorder | Common Mental DisordersUnited Kingdom
-
Mental Health Services in the Capital Region, DenmarkCentral Denmark Region; Københavns Kommune; The Danish Agency for Labour Market... and other collaboratorsCompletedPersonality Disorders | Depression | Stress | Anxiety | Common Mental Disorders | Functional Disease PresentDenmark
-
Karolinska InstitutetSwedish Council for Working Life and Social ResearchCompletedDepression | Anxiety Disorders | Adjustment Disorders | Common Mental DisorderSweden
-
Instituto Ecuatoriano de Enfermedades DigestivasUniversity of Sao Paulo; Universitair Ziekenhuis Brussel; The Methodist Hospital... and other collaboratorsCompletedCommon Bile Duct Neoplasms | Non-Neoplastic Bile Duct DisorderUnited States, Ecuador, Belgium, Brazil
-
Universidad de CórdobaMinisterio de Economía y Competitividad, SpainCompletedDepression | Anxiety Disorders | Somatoform Disorders | Common Mental DisordersSpain
-
University of KonstanzLudwig-Maximilians - University of Munich; Jimma UniversityCompletedCommon Mental Disorders (CMD) | Psychotic Symptoms
-
Region MidtJylland DenmarkCompletedDepression | Anxiety | Common Mental Disorders | Psychiatric Disorders | Somatoform DisorderDenmark
-
The University of Hong KongCompletedCommon Mental DisordersHong Kong
Clinical Trials on Antipsychotic drugs
-
University College, LondonCompletedSchizophrenia | Schizoaffective Disorder | Delusional Disorder | Schizophreniform DisordersUnited Kingdom
-
Fundación Marques de ValdecillaCentro de Investigación Biomédica en Red de Salud Mental; Instituto de Investigación...CompletedSchizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Schizophrenia RelapseSpain
-
Western University, CanadaCompletedPregnancy Complications | Bipolar Disorder
-
Fayoum UniversityCompletedAntipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic PatientsSchizophrenia Spectrum and Other Psychotic Disorders | Periodontal DiseasesEgypt
-
Psychiatric University Hospital, ZurichRecruiting
-
Janssen-Cilag, S.A.CompletedSchizophrenia | Schizoaffective Disorder | Schizophreniform Disorder
-
Tianjin Anding HospitalCompletedSchizophrenia | Therapeutics
-
Nathan Kline Institute for Psychiatric ResearchTerminatedSchizophrenia | Schizoaffective Disorder
-
Herlev and Gentofte HospitalOdense University Hospital; Zealand University Hospital; Aarhus University Hospital and other collaboratorsRecruitingDeath, Sudden, Cardiac | Arrythmia | Antipsychotics and Neuroleptics ToxicityDenmark
-
University of Illinois at ChicagoNational Institute of Mental Health (NIMH)Terminated