Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure (CRF-QoL)
June 3, 2026 updated by: Guy's and St Thomas' NHS Foundation Trust
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
Study Type
Observational
Enrollment (Estimated)
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Neeraj Shah, MBBS
- Phone Number: +442071888070
- Email: neeraj.shah@gstt.nhs.uk
Study Contact Backup
- Name: Patrick Murphy, MBBS
- Phone Number: +442071888070
- Email: patrick.murphy@gstt.nhs.uk
Study Locations
-
-
-
London, United Kingdom, SE1 7EH
- Recruiting
- Guy's and St. Thomas NHS Foundation Trust
-
Contact:
- Gill Arbane
- Email: gill.arbane@gstt.nhs.uk
-
Contact:
- Neeraj Shah
- Email: neeraj.shah@gstt.nhs.uk
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Patients with chronic respiratory failure being treated with a form of ventilation of mechanical insufflation-exsufflation therapy.
Description
Inclusion Criteria:
Diagnosed with chronic respiratory failure receiving any of:
- Non-invasive ventilation
- Prolonged mechanical ventilation
- Mechanical insufflation-exsufflation therapy
Exclusion Criteria:
- Aged <18
- Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Non-invasive ventilation
Users of non-invasive ventilation
|
HRQoL questionnaires
|
|
Long term tracheostomy ventilation
Long term tracheostomy ventilated patients
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
HRQoL score
Time Frame: Day 0: At the first outpatient clinical consultation with the clinical team
|
Outcome of various HRQoL assessment tools.
|
Day 0: At the first outpatient clinical consultation with the clinical team
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Change in HRQoL score
Time Frame: 6 months following first assessment for Outcome 1
|
Change in HRQoL assessment tool score at next clinical follow-up.
|
6 months following first assessment for Outcome 1
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Chair: Patrick Murphy, MBBS, Guy's and St Thomas' NHS Foundation Trust
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 19, 2019
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Study Registration Dates
First Submitted
December 17, 2019
First Submitted That Met QC Criteria
January 21, 2020
First Posted (Actual)
January 22, 2020
Study Record Updates
Last Update Posted (Actual)
June 4, 2026
Last Update Submitted That Met QC Criteria
June 3, 2026
Last Verified
June 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Nervous System Diseases
- Pathologic Processes
- Chronic Disease
- Disease Attributes
- Respiratory Tract Diseases
- Lung Diseases
- Respiration Disorders
- Lung Diseases, Obstructive
- Signs and Symptoms, Respiratory
- Pathological Conditions, Signs and Symptoms
- Signs and Symptoms
- Pulmonary Disease, Chronic Obstructive
- Respiratory Insufficiency
- Neuromuscular Diseases
- Hypoventilation
- Health Care Quality, Access, and Evaluation
- Investigative Techniques
- Epidemiologic Methods
- Data Collection
- Health Care Evaluation Mechanisms
- Quality of Health Care
- Public Health
- Environment and Public Health
- Surveys and Questionnaires
Other Study ID Numbers
- CRF-QoL
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.