Covid-19 Pediatric Observatory (PANDOR)

November 21, 2022 updated by: Centre Hospitalier Intercommunal Creteil

In early December 2019, cases of pneumonia of unknown origin were reported in Wuhan, Hubei Province in the People's Republic of China. The disease spreads rapidly and the number of sick people is increasing. On January 3, 2020 a new virus of the coronavirus family is identified in samples of bronchoalveolar lavage fluid from a patient in Wuhan and subsequently confirmed as the cause of these pneumonias. On 7 January 2020, the World Health Organization (WHO) designated it as the new coronavirus 2019 (i.e. 2019-nCoV). On 11 February 2020, the WHO designated the disease associated with 2019-nCoV as coronavirus 2019 disease (COVID-19). On 12 March, WHO announced that the COVID-19 outbreak is a pandemic.

As of March 24, 2020, more than 375,000 cases of COVID-19 had been diagnosed with more than 16,000 deaths attributed to this virus. (Ref WHO https://www.who.int/emergencies/diseases/novel-coronavirus-2019 ).

In France, the number of cases rose from 105 cases at the end of February to 19615 confirmed cases on March 24. (Source Public Health France). Most of the cases are adults. However, children are not completely spared and serious cases have been described. These severe cases can be respiratory or extra-respiratory (e.g. myocarditis). We also know that pediatric and adult cases differ in terms of clinical, biological and imaging findings, particularly chest CT scans. However, the description of paediatric pictures, especially severe forms and the involvement of children suffering from co-morbidities, remains poorly reported. Finally, the risk factors for serious cases in children remain largely unknown.

This observatory aim to describe the clinical phenotypes of hospitalized pediatric patients with Covid19 in France, according to age groups. Moreover for a subgroup of patients, informations regarding the long covid will be reported.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

5000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
      • Agen, France
        • Recruiting
        • Ch St Esprit
        • Contact:
          • Marie Mizzi
      • Aix-en-Provence, France
        • Recruiting
        • Ch General Aix En Provence -
        • Contact:
          • Claire Charreton
      • Angers, France
        • Recruiting
        • CHU Angers
        • Contact:
          • Gerald Boussicault
        • Sub-Investigator:
          • Leboucher
        • Sub-Investigator:
          • Valérie Rabier
      • Angoulème, France
        • Recruiting
        • CH D'Angouleme
        • Contact:
          • Sylvie Roullaud
      • Annecy, France
        • Recruiting
        • Pringy - Ch D'Annecy
        • Contact:
          • Chantal Peigne
      • Argenteuil, France
        • Recruiting
        • CH Argenteuil
        • Contact:
          • Philippe Bensaid, MD
      • Armentières, France
        • Recruiting
        • Ch Armentieres
        • Contact:
          • Sophie Enchery
      • Arpajon, France
        • Recruiting
        • CH Arpajon
        • Contact:
          • Ekaterina KUTSIA
      • Auxerre, France
        • Recruiting
        • Ch Auxerre
        • Contact:
          • Bertrand Soto
        • Sub-Investigator:
          • Mougenot
      • Avignon, France
        • Recruiting
        • CH GENERAL Henri Duffaut
        • Contact:
          • Charlotte Pons
      • Besançon, France
        • Recruiting
        • CHU de Besancon
        • Contact:
          • Raphaël Anxionnat
      • Caen, France
        • Recruiting
        • Hopital Femme Enfant
        • Sub-Investigator:
          • Valentin
      • Cergy-Pontoise, France
        • Recruiting
        • CH de Pontoise
        • Contact:
          • Blandine Robert
        • Sub-Investigator:
          • Mohamed-Amine Yangui
      • Chalon-sur-Saône, France
        • Recruiting
        • Ch W. Morey
      • Chambéry, France
        • Recruiting
        • CH de Chambery
        • Contact:
          • Charlène Dupré
      • Chartres, France
        • Recruiting
        • Ch Hotel Dieu
        • Contact:
          • Rémi Kom
      • Clermont-Ferrand, France
        • Recruiting
        • CHU Estaing
        • Contact:
          • Isabelle Petit
      • Colmar, France
        • Recruiting
        • Hôpital Louis Pasteur
        • Contact:
          • Didier CHOGNOT
        • Principal Investigator:
          • Marie Szulc
      • Colombes, France
        • Recruiting
        • Hopital Louis Mourrier
        • Contact:
          • Danekova
      • Corbeil-Essonnes, France
        • Recruiting
        • CH SUd Francilien
        • Contact:
          • Sebastien Rouget
      • Creteil, France, 94010
        • Recruiting
        • Centre Hospitalier Intercommunal de Créteil
        • Principal Investigator:
          • Xavier DURRMEYER
        • Contact:
          • Camille Jung
        • Sub-Investigator:
          • Ralph EPAUD
        • Sub-Investigator:
          • Fouad Madhi
      • Dax, France
        • Recruiting
        • CH de Dax
        • Contact:
          • Claude Chenel
      • Dijon, France
        • Recruiting
        • Hopital D'Enfants Chu Dijon
        • Contact:
          • Frédéric Huet
        • Sub-Investigator:
          • Verney
      • Elbeuf, France
        • Recruiting
        • CH Louviers Val de Reuil
        • Contact:
          • Dana Dabbagh
      • Gonesse, France
        • Recruiting
        • CH Gonesse
        • Contact:
          • Maryssa Sarakbi
      • Hyères, France
        • Recruiting
        • CH d'HYERES
        • Contact:
          • danielle Roybet
      • Jossigny, France
        • Recruiting
        • CH de Marne la Vallée
        • Contact:
          • Nathalie Garrec
        • Sub-Investigator:
          • Videsheka MADPATHAGE SENANAYAKE
        • Sub-Investigator:
          • Tchadie Bommenel
      • La Tronche, France
        • Recruiting
        • CHRU de Grenoble
        • Contact:
          • Cécile Bost-Bru
        • Principal Investigator:
          • Fruscione
      • Le Havre, France
        • Recruiting
        • CHGénéral du HAVRE
        • Contact:
          • Belgaid Abdelmalek
      • Lille, France
        • Recruiting
        • Hopital Jeanne de Flandre
        • Contact:
          • Stéphane Leteurtre
      • Lille, France
        • Recruiting
        • Hopital Roger Salengro - Lille
        • Contact:
          • François DUBOS, MD
        • Principal Investigator:
          • Alain Martinot
      • Lille, France
        • Recruiting
        • Hôpital Saint Vincent de Paul
        • Contact:
          • Valentine Hoeusler
        • Principal Investigator:
          • Nicolas Kalach
      • Longjumeau, France
        • Recruiting
        • CH de Longjumeau
        • Contact:
          • Sarah Ducrocq
      • Lorient, France
        • Recruiting
        • Lorient - Ch de Bretagne Sud
        • Contact:
          • Camille Le Stradic, MD
      • Lyon, France
        • Recruiting
        • Hopital Femme Mere Enfant-Bron
        • Contact:
          • Manon Passard
        • Principal Investigator:
          • Manon Passard
        • Principal Investigator:
          • Antoine Ouziel
      • Mantes-la-Jolie, France
        • Recruiting
        • Hopital de Mantes
        • Contact:
          • Béatrice Pellegrino
      • Marseille, France
        • Recruiting
        • Hopital Nord Enfants
        • Contact:
          • Philippe Minodier
      • Meaux, France
        • Recruiting
        • Hôpital de Meaux
        • Contact:
          • Olivier Vignaud
        • Sub-Investigator:
          • Fleury Marjory
      • Meulin, France
        • Recruiting
        • CH de Melun
        • Contact:
          • Caroline Thach
      • Montargis, France
        • Recruiting
        • CH de Montargis
        • Contact:
          • Richard Gruss
      • Montbrison, France
        • Recruiting
        • CH de MONTBRISON
        • Contact:
          • Christine Roche
      • Montpellier, France
        • Recruiting
        • Hopital Arnaud de Villeneuve
        • Contact:
          • Léa THEVENET
      • Nancy, France
        • Recruiting
        • CHRU de Nancy
        • Contact:
          • Florent Girard
        • Principal Investigator:
          • Cyril Schweitzer
      • Nantes, France
        • Recruiting
        • Nantes - Hopital Mere Enfant
        • Contact:
          • Anne Drouard
      • Neuilly-sur-Seine, France
        • Recruiting
        • Ch de Neuilly Sur Seine
        • Contact:
          • Mariana Marin
      • Nice, France
        • Recruiting
        • Hôpital Lenval
        • Contact:
          • hervé Haas
      • Nîmes, France
        • Recruiting
        • CHU NIMES Caremeau
        • Contact:
          • Sophie Odorico, MD
      • Orléans, France
        • Recruiting
        • CHR Orléans
        • Contact:
          • Françoise Monceaux
        • Principal Investigator:
          • Imen Jhaouat
      • Paris, France, 75004
        • Recruiting
        • Assistance Publique Hopitaux De Paris
        • Principal Investigator:
          • Valérie Biran
        • Contact:
          • François Angoulvant
        • Principal Investigator:
          • François Angoulvant
        • Principal Investigator:
          • Albert Faye
        • Principal Investigator:
          • Naim Ouldali
        • Principal Investigator:
          • Mickael Levy
        • Principal Investigator:
          • laurent Dupic
        • Principal Investigator:
          • julie Toubiana
        • Principal Investigator:
          • Jean Gaschignard
        • Principal Investigator:
          • Nevena Danekava
        • Principal Investigator:
          • Jeremy Do Cao
        • Principal Investigator:
          • Karen Milcent
        • Principal Investigator:
          • Sebastien Walser
        • Principal Investigator:
          • Loic De Pontual
        • Principal Investigator:
          • Gregoire Benoist
        • Principal Investigator:
          • Tama Guiddir
        • Principal Investigator:
          • Irina Craiu
        • Principal Investigator:
          • Anne-Sophie Romain
        • Principal Investigator:
          • David Dawei
      • Perpignan, France
        • Recruiting
        • Hopital St Jean Roussillon
        • Contact:
          • Paulin Meslin
      • Poissy, France
        • Recruiting
        • POISSY - CH de POISSY
        • Contact:
          • Philippe Blanc
      • Quimper, France
        • Recruiting
        • QUIMPER - CH de Cornouaille
        • Contact:
          • Camille Loeile
      • RANG du FLIERS, France
        • Recruiting
        • RANG du FLIERS - C.H.A.M.
        • Contact:
          • Sylvie Louf
      • Reims, France
        • Recruiting
        • Hopital Américain CHU REIMS
        • Contact:
          • Elmerich Florence
      • Rodez, France
        • Recruiting
        • CH Rodez
        • Contact:
          • Bernard Caurier
      • Romans-sur-Isère, France
        • Recruiting
        • CH de ROMANS
        • Contact:
          • Patricia Guglielmino
      • Rouen, France
        • Recruiting
        • CHU Rouen
        • Contact:
          • Nathalie Mestre
      • Rouen, France
        • Recruiting
        • Hôpital Charles-Nicolle
      • Saint Etienne, France
        • Recruiting
        • CHU St Etienne
        • Contact:
          • Aymeric CANTAIS
      • Saint-Denis, France
        • Recruiting
        • Ch de Saint Denis
        • Contact:
          • Alexis Mandelcwajg, MD
      • Saint-Malo, France
        • Recruiting
        • CH de Saint Malo
        • Contact:
          • Jean-Marie Lepage
      • Sallanches, France
        • Recruiting
        • Ch Du Pays Du Mont Blanc
        • Contact:
          • Emmanuelle Dessioux
      • Salon de Provence, France
        • Recruiting
        • Chg Salon de Provence
        • Contact:
          • Eric Moulène
      • Strasbourg, France
        • Recruiting
        • CH Hautepierre
        • Contact:
          • Jeanne Bordet
        • Principal Investigator:
          • Yvan De Feraudy
      • Tarbes, France
        • Recruiting
        • CH Tarbes
        • Contact:
          • Vanessa Latry, MD
      • Thionville, France
        • Recruiting
        • CH Bel Air
        • Contact:
          • Jean-Marc Schneider
      • Toulon, France
        • Recruiting
        • Hôpital Sainte Musse
        • Contact:
          • Paul Casha
      • Toulouse, France
        • Recruiting
        • CHU Toulouse-hôpital des Enfants
        • Contact:
          • camille Brehin
      • Tours, France
        • Recruiting
        • Hôpital Gatien De Clocheville
        • Contact:
          • Zoha Maakaroun-Vermesse
        • Principal Investigator:
          • Charlotte Idier
      • Troyes, France
        • Recruiting
        • CH de Troyes
        • Contact:
          • Brigitte zimmerman
        • Principal Investigator:
          • Stéphane Sanchez
        • Principal Investigator:
          • Brigitte zimmerman
      • Trévenans, France
        • Recruiting
        • Hôpital Nord Franche-Comté
        • Contact:
          • Nicoleta Ursulescu
      • Vannes, France
        • Recruiting
        • CH Bretagne Atlantique
        • Contact:
          • Cécilia Marques, MD
      • Versailles, France
        • Recruiting
        • Ch Le Chesnay
        • Contact:
          • Marie-Aliette Dommergue
        • Principal Investigator:
          • Marie-Aliette Dommergue
      • Villeneuve-Saint-Georges, France
        • Recruiting
        • Hopital de Villeneuve Saint Georges
        • Contact:
          • Aurélie Garraffo, MD
      • Épinal, France
        • Recruiting
        • CH Jean Monnet
        • Contact:
          • Brigitte Auburtin
    • La Réunion
      • Saint Denis, La Réunion, France
        • Recruiting
        • CHU Felix Guyon
        • Contact:
          • Benjamin Azemar

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 second to 18 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

children hospitalized with covid19

Description

Inclusion Criteria:

  • Children < 18 years old
  • Admitted in French pediatric wards
  • With a confirmed COVID-19 infection. ( on Nasal and pharyngeal swab specimens or blood samples tested positive for 2019-nCoV nucleic acid using real-time reverse-transcriptase polymerase-chain-reaction (RT- PCR) assay; or on typical chest CT signs

Exclusion Criteria:

  • Expressed refusal to participate

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Other

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
hospitalized children with Covid19
- Children < 18 years old Patients under 18 years old, admitted in French pediatric wards with a confirmed COVID-19 infection on Nasal and pharyngeal swab specimens or blood samples tested positive for 2019-nCoV nucleic acid using real-time reverse-transcriptase polymerase-chain-reaction (RT- PCR) assay; or on typical chest CT signs
Other: hospitalized children with Covid19
All patients under 18 years hospitalized with a covid19 diagnosis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Percentage of children with severe or critical form.
Time Frame: Day 14
Day 14

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percentage of children requiring intensive care support
Time Frame: at admission
at admission
Percentage of children requiring intensive care support
Time Frame: at day 14
at day 14
Clinical symptoms of children
Time Frame: at admission
requiring intensive care support or not
at admission
Clinical symptoms of children
Time Frame: day 14
requiring intensive care support or not
day 14
Biological results of children
Time Frame: at admission
requiring intensive care support or not
at admission
Biological results of children
Time Frame: day 14
requiring intensive care support or not
day 14
CT chest of children
Time Frame: at admission
requiring intensive care support or not
at admission
Pulmonary echography
Time Frame: Day 14
requiring intensive care support or not
Day 14
nasopharynx SARScov2 PCR
Time Frame: at admission
at admission
nasopharynx sarscov2 load
Time Frame: at day 7
if available
at day 7
nasopharynx multiplex PCR
Time Frame: at admission
if available
at admission
number of hospital days
Time Frame: up to 12months
days
up to 12months
Evaluation of long covid
Time Frame: up to 12months
up to 12months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Intercommunal Creteil

Collaborators

Association Clinique Thérapeutique Infantile du val de Marne
GPIP
Francophone Pediatric Resuscitation and Emergency Group (GFRUP)
Société Française de Pédiatrie

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 7, 2020

Primary Completion (Anticipated)

June 30, 2024

Study Completion (Anticipated)

June 30, 2024

Study Registration Dates

First Submitted

March 30, 2020

First Submitted That Met QC Criteria

April 6, 2020

First Posted (Actual)

April 7, 2020

Study Record Updates

Last Update Posted (Actual)

November 25, 2022

Last Update Submitted That Met QC Criteria

November 21, 2022

Last Verified

November 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PANDOR

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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