Different PEEP Settings of COVID-19 Induced ARDS

April 21, 2020 updated by: Chun Pan, Southeast University, China

Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Jiangsu
      • Nanjing, Jiangsu, China, 210009
        • Zhongda Hospital, Southeast University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • COVID-19 patients with mechanical ventilation
  • PO2/FIO2<300mmHg
  • ages>18 years

Exclusion Criteria:

  • pneumothorax
  • pregnant
  • hemodynamics is unstable

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Optimizing oxygenation
Best oxygenation during PEEP titration
Other: Gas exchanges at different PEEP
Gas exchanges measurement at different PEEP
Experimental: Optimizing compliance
Best compliance during PEEP titration
Other: lung mechanics at different PEEP
lung mechanics measurement at different PEEP
Experimental: ARDSnet
PEEP settings according to ARDSnet table
Other: Hemodynamics changes at different PEEP
Hemodynamics changes measurement at different PEEP

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Respiratory system compliance improvement
Time Frame: 20 minutes
the respiratory system compliance was compared among three groups
20 minutes

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Gas echanges improvement
Time Frame: 20 minutes
P/Fwere compared among three groups
20 minutes

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
hemodynamics improvement
Time Frame: 20 minutes
MAP were compared among three groups
20 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Southeast University, China

Investigators

  • Study Director: Chun C Pan, Zhongda hospital, Southeast University, Jiangsu, China

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 5, 2020

Primary Completion (Actual)

March 25, 2020

Study Completion (Actual)

March 25, 2020

Study Registration Dates

First Submitted

April 13, 2020

First Submitted That Met QC Criteria

April 21, 2020

First Posted (Actual)

April 24, 2020

Study Record Updates

Last Update Posted (Actual)

April 24, 2020

Last Update Submitted That Met QC Criteria

April 21, 2020

Last Verified

April 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • COVID-19 PEEP titration

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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