- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04455750
A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy (CASPAR)
CASPAR - A Phase III Trial of Enzalutamide and Rucaparib as a Novel Therapy in First-Line Metastatic Castration-Resistant Prostate Cancer
Study Overview
Status
Conditions
Detailed Description
PRIMARY OBJECTIVES:
I. To compare radiographic progression-free survival (rPFS) and overall survival (OS) with enzalutamide and rucaparib camsylate (rucaparib) versus enzalutamide alone for patients with metastatic castration resistant prostate cancer commencing first-line therapy.
II. (PK substudy) To evaluate the safety and tolerability of rucaparib and enzalutamide combination III. (Quality of life substudy) To compare quality of life as measured by FACT-P Trial Outcome Index in patients with mCRPC who receive enzalutamide plus rucaparib vs enzalutamide alone at the 12-month time point (primary QOL timepoint).
SECONDARY OBJECTIVES:
I. To compare rPFS and OS with enzalutamide and rucaparib versus enzalutamide alone within homologous-recombination repair (HRR) aberrant and wild-type patients.
II. To evaluate the effects of concurrent administration of rucaparib on time to unequivocal clinical progression.
III. To evaluate the effects of concurrent administration of rucaparib on best radiographic response using Prostate Cancer Working Group 3 (PCWG3) criteria.
IV. To evaluate the effects of concurrent administration of rucaparib on duration of overall response.
V. To evaluate the effects of concurrent administration of rucaparib on prostate specific antigen (PSA) response rate.
VI. To evaluate the effects of concurrent administration of rucaparib on best response by serum PSA by months 7 and 13.
VII. To evaluate the effects of concurrent administration of rucaparib on time to first symptomatic skeletal event (SSE).
VIII. To evaluate the effects of concurrent administration of rucaparib on safety and tolerability as measured by National Cancer Institute (NCI) Common Toxicity Criteria; and trial discontinuation for treatment emergent toxicities.
IX. To compare performance of plasma-based and tissue-based genomic profiling in detection of homologous-recombination repair mutation (HRRm) in metastatic castration-resistant prostate cancer (mCRPC).
OUTLINE:
In the randomized, placebo-controlled phase III study, patients will be randomized to 1 of 2 arms:
ARM I: Patients will receive enzalutamide orally (PO) once daily (QD) and rucaparib PO twice daily (BID). Patients who did not undergo bilateral orchiectomy will also receive androgen deprivation therapy (ADT) consisting of leuprolide acetate intramuscularly (IM), goserelin acetate subcutaneously (SC) every 12 weeks or degarelix SC. Cycles will repeat every 28 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients will receive enzalutamide PO QD and placebo PO BID. Patients who did not undergo bilateral orchiectomy will also receive ADT consisting of leuprolide acetate IM, goserelin acetate SC every 12 weeks or degarelix SC. Cycles will repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After the completion of study treatment, patients will be followed every 3 months for 2 years, then every 6 months for 3 years.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Contact
- Name: Arpit Rao, MD
- Phone Number: 713-798-4508
- Email: arpit.rao@bcm.edu
Study Locations
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Alaska
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Anchorage, Alaska, United States, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, United States, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, United States, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, United States, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, United States, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, United States, 99504
- Anchorage Radiation Therapy Center
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Arizona
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Phoenix, Arizona, United States, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Hot Springs, Arkansas, United States, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Antioch, California, United States, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, United States, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Dublin, California, United States, 94568
- Kaiser Permanente Dublin
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Fremont, California, United States, 94538
- Kaiser Permanente-Fremont
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Fresno, California, United States, 93720
- Kaiser Permanente-Fresno
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Modesto, California, United States, 95356
- Kaiser Permanente-Modesto
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Oakland, California, United States, 94611
- Kaiser Permanente-Oakland
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Richmond, California, United States, 94801
- Kaiser Permanente-Richmond
-
Roseville, California, United States, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, United States, 95814
- Kaiser Permanente Downtown Commons
-
Sacramento, California, United States, 95823
- Kaiser Permanente-South Sacramento
-
Saint Helena, California, United States, 94574
- Saint Helena Hospital
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San Diego, California, United States, 92123
- Sharp Memorial Hospital
-
San Francisco, California, United States, 94115
- Kaiser Permanente-San Francisco
-
San Jose, California, United States, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro, California, United States, 94577
- Kaiser Permanente San Leandro
-
San Luis Obispo, California, United States, 93401
- Pacific Central Coast Health Center-San Luis Obispo
-
San Rafael, California, United States, 94903
- Kaiser San Rafael-Gallinas
-
Santa Clara, California, United States, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Maria, California, United States, 93444
- Mission Hope Medical Oncology - Santa Maria
-
Santa Rosa, California, United States, 95403
- Kaiser Permanente-Santa Rosa
-
South San Francisco, California, United States, 94080
- Kaiser Permanente-South San Francisco
-
Stockton, California, United States, 95210
- Kaiser Permanente-Stockton
-
Vacaville, California, United States, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vacaville, California, United States, 95687
- Northbay Cancer Center
-
Vallejo, California, United States, 94589
- Kaiser Permanente-Vallejo
-
Walnut Creek, California, United States, 94596
- Kaiser Permanente-Walnut Creek
-
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Colorado
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, United States, 80210
- Porter Adventist Hospital
-
Durango, Colorado, United States, 81301
- Mercy Medical Center
-
Durango, Colorado, United States, 81301
- Southwest Oncology PC
-
Lakewood, Colorado, United States, 80228
- Saint Anthony Hospital
-
Littleton, Colorado, United States, 80122
- Littleton Adventist Hospital
-
Longmont, Colorado, United States, 80501
- Longmont United Hospital
-
Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Parker, Colorado, United States, 80138
- Parker Adventist Hospital
-
Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
-
-
Connecticut
-
West Haven, Connecticut, United States, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
-
-
District of Columbia
-
Washington, District of Columbia, United States, 20010
- MedStar Washington Hospital Center
-
Washington, District of Columbia, United States, 20037
- George Washington University Medical Center
-
-
Florida
-
Aventura, Florida, United States, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
-
Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
-
Miami Beach, Florida, United States, 33140
- Mount Sinai Medical Center
-
-
Georgia
-
Augusta, Georgia, United States, 30901
- Augusta Oncology Associates PC-D'Antignac
-
Augusta, Georgia, United States, 30909
- Augusta Oncology Associates PC-Wheeler
-
Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
-
Hawaii
-
'Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
-
Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, United States, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, United States, 96819
- Kaiser Permanente Moanalua Medical Center
-
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Idaho
-
Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, United States, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, United States, 83686
- Saint Luke's Cancer Institute - Nampa
-
Nampa, Idaho, United States, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, United States, 83864
- Kootenai Cancer Clinic
-
Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
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Illinois
-
Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
-
Burr Ridge, Illinois, United States, 60527
- Loyola Center for Health at Burr Ridge
-
Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, United States, 62918
- SIH Cancer Institute
-
Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, United States, 60611
- Northwestern University
-
Chicago, Illinois, United States, 60612
- Rush University Medical Center
-
Chicago, Illinois, United States, 60612
- University of Illinois
-
Chicago, Illinois, United States, 60657
- Advocate Illinois Masonic Medical Center
-
Danville, Illinois, United States, 61832
- Carle at The Riverfront
-
DeKalb, Illinois, United States, 60115
- Northwestern Medicine Cancer Center Kishwaukee
-
Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, United States, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, United States, 60134
- Northwestern Medicine Cancer Center Delnor
-
Harvey, Illinois, United States, 60426
- Ingalls Memorial Hospital
-
Homer Glen, Illinois, United States, 60491
- Loyola Medicine Homer Glen
-
Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, United States, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, United States, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
-
Park Ridge, Illinois, United States, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
-
Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, United States, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
-
River Forest, Illinois, United States, 60305
- West Suburban Medical Center
-
Springfield, Illinois, United States, 62781
- Memorial Medical Center
-
Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, United States, 62702
- Springfield Clinic
-
Urbana, Illinois, United States, 61801
- Carle Cancer Center
-
Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, United States, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Washington, Illinois, United States, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Richmond, Indiana, United States, 47374
- Reid Health
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, United States, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, United States, 50036
- McFarland Clinic - Boone
-
Carroll, Iowa, United States, 51401
- Saint Anthony Regional Hospital
-
Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, United States, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, United States, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, United States, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, United States, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
-
Fort Dodge, Iowa, United States, 50501
- Trinity Regional Medical Center
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic - Trinity Cancer Center
-
Jefferson, Iowa, United States, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, United States, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
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Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
London, Kentucky, United States, 40741
- Saint Joseph London
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Maine
-
Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
-
Michigan
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Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Brighton, Michigan, United States, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, United States, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Canton, Michigan, United States, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, United States, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, United States, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, United States, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Grosse Pointe Woods, Michigan, United States, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, United States, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, United States, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49009
- Ascension Borgess Cancer Center
-
Lansing, Michigan, United States, 48912
- Sparrow Hospital
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, United States, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Norton Shores, Michigan, United States, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, United States, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Reed City, Michigan, United States, 49677
- Spectrum Health Reed City Hospital
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saint Joseph, Michigan, United States, 49085
- Marie Yeager Cancer Center
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, United States, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, United States, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Deer River, Minnesota, United States, 56636
- Essentia Health - Deer River Clinic
-
Duluth, Minnesota, United States, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hibbing, Minnesota, United States, 55746
- Essentia Health Hibbing Clinic
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Medical Center
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Sandstone, Minnesota, United States, 55072
- Essentia Health Sandstone
-
Thief River Falls, Minnesota, United States, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, United States, 55792
- Essentia Health Virginia Clinic
-
Worthington, Minnesota, United States, 56187
- Sanford Cancer Center Worthington
-
-
Missouri
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Columbia, Missouri, United States, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Farmington, Missouri, United States, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, United States, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Las Vegas, Nevada, United States, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, United States, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Hackensack, New Jersey, United States, 07601
- Hackensack University Medical Center
-
Paterson, New Jersey, United States, 07503
- Saint Joseph's Regional Medical Center
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, United States, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, United States, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
Flushing, New York, United States, 11355
- The New York Hospital Medical Center of Queens
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Jamaica, New York, United States, 11432
- Queens Hospital Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
Nyack, New York, United States, 10960
- Nyack Hospital
-
-
North Carolina
-
Clemmons, North Carolina, United States, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Wilkesboro, North Carolina, United States, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, United States, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, United States, 58104
- Sanford Medical Center Fargo
-
-
Ohio
-
Centerville, Ohio, United States, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, United States, 45459
- Dayton Physicians LLC-Miami Valley South
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Findlay, Ohio, United States, 45840
- Armes Family Cancer Center
-
Franklin, Ohio, United States, 45005
- Dayton Physicians LLC-Atrium
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Kettering, Ohio, United States, 45409
- Greater Dayton Cancer Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Cancer Center
-
Sylvania, Ohio, United States, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, United States, 97701
- Saint Charles Health System
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, United States, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, United States, 97420
- Bay Area Hospital
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Medical Center-Ontario
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, United States, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
-
South Carolina
-
Bluffton, South Carolina, United States, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Hilton Head Island, South Carolina, United States, 29926-3827
- South Carolina Cancer Specialists PC
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Avera Cancer Institute-Aberdeen
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
Yankton, South Dakota, United States, 57078
- Avera Cancer Institute at Yankton
-
-
Texas
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Houston, Texas, United States, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, United States, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, United States, 77030
- Ben Taub General Hospital
-
-
Utah
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Saint Johnsbury, Vermont, United States, 05819
- Norris Cotton Cancer Center-North
-
-
Virginia
-
Lynchburg, Virginia, United States, 24501
- Centra Lynchburg Hematology-Oncology Clinic Inc
-
Richmond, Virginia, United States, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Richmond, Virginia, United States, 23229
- Virginia Cancer Institute
-
South Hill, Virginia, United States, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, United States, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Aberdeen, Washington, United States, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, United States, 98004
- FHCC Overlake
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, United States, 98310
- Harrison Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Kirkland, Washington, United States, 98034
- Seattle Cancer Care Alliance at EvergreenHealth
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Longview, Washington, United States, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, United States, 98368
- Jefferson Healthcare
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, United States, 98133
- FHCC at Northwest Hospital
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, United States, 98584
- Providence Regional Cancer System-Shelton
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Yelm, Washington, United States, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
-
Wisconsin
-
Ashland, Wisconsin, United States, 54806
- Duluth Clinic Ashland
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, United States, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Germantown, Wisconsin, United States, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, United States, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Milwaukee, Wisconsin, United States, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, United States, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Histologic/cytologic documentation of prostate adenocarcinoma
- Adequate archival tumor specimen or archival slides must be available to be tested as part of the trial screening (most recent metastatic site biopsy preferred, but primary prostate biopsy allowed if metastatic biopsy is not available or inadequate. A new biopsy is not required for pre-registration in the trial as long as sufficient archival tissue is available). Due to significant variability between tests, results from an existing targeted next-generation exome sequencing test may not be used for this trial
Progressive disease must be demonstrated at study entry while the patient is on continuous androgen deprivation therapy (ADT) or status post orchiectomy. Progressive disease is defined as one or more of the following criteria:
- PSA progression, defined by at least 2 consecutive rising PSA values at a minimum of 1-week intervals with the most recent PSA value being 1.0 ng/mL or higher, if confirmed PSA rise is the only indication of progression. Patients who received an anti-androgen must have PSA progression after withdrawal of anti-androgen therapy (>=4 weeks since last flutamide, bicalutamide or nilutamide, apalutamide or darolutamide)
- Radiographic progression per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for soft tissue lesions
- Bone metastasis progression per Prostate Cancer Working Group 3 (PCWG3) criteria
- Measurable or non-measurable metastatic disease
- No prior therapy for metastatic castration-resistant prostate cancer, defined as a treatment given for prostate cancer with radiographically-detectable metastasis and a serum testosterone level less than 50 ng/dl (1.73 nmol/L) at the time of registration
- >= 2 weeks or 5 half-lives (whichever is shorter) since prior therapy with flutamide, dutasteride, bicalutamide, niltamide, finasteride, aminoglutethimide, estrogens, cytoproterone, chemotherapy, abiraterone, apalutamide, or darolutamide
- >= 4 weeks or 5 half-lives (whichever is shorter) since any prior investigational therapy
- >= 4 weeks since a major surgery or radiation
- No prior therapy with enzalutamide, rucaparib or any other PARP inhibitor, or platinum chemotherapy
- Prior docetaxel and/or novel anti-androgen use is allowed only if given in the hormone-sensitive non-metastatic or metastatic, or castration-resistant non-metastatic disease setting
- Patient must have discontinued all previous treatments for cancer (except ADT and bone anti-responsive therapies such as denosumab or zoledronic acid) and must have recovered from all acute side effects of prior therapy or surgical procedures to =< grade 1 or baseline prior to randomization, with the exception of fatigue, alopecia or peripheral neuropathy
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Absolute neutrophil count (ANC) >= 1,500/mm^3
- Platelet count >= 100,000/mm^3
- Hemoglobin >= 10 g/dL
- Serum testosterone =< 50 ng/dl (=< 1.73 nmol/L)
- Serum creatinine =< 1.5 x upper limit of normal (ULN)
- Total bilirubin =< 1.5 x upper limit of normal (ULN)
- Aspartate transaminase (AST)/alanine transferase (ALT) =< 2.5 x upper limit of normal (ULN)
- No clinically suspected central nervous system (CNS) (leptomeningeal or parenchymal) metastases. Patients with a history of CNS metastasis(s) will be allowed as long (1) as the metastatic site(s) were adequately treated as demonstrated by clinical and radiographic improvement, AND (2) the patient has recovered from the intervention (no residual adverse events > Common Terminology Criteria for Adverse Events [CTCAE] grade 1), AND (3) the patient has remained without occurrence of new or worsening CNS symptoms for a period of 28 days prior to pre-registration
- No known or suspected history of cytopenia (low white blood cell [WBC], hemoglobin or platelet count) of greater than 3 months duration with an unknown cause, myelodysplastic syndrome, or hematologic malignancies
- No blood product transfusion, granulocyte/granulocyte-macrophage-colony stimulating factor (G-CSF/GM-CSF), or erythropoietin/thrombopoietin use within 14 days of pre-registration
- No history of syncope of cardiovascular etiology, uncontrolled cardiac arrhythmia, history of Mobitz II second degree or third degree heart block without a permanent pacemaker in place, myocardial ischemia or infarction, severe or unstable angina, New York Heart Association (NYHA) class II to IV heart failure, or stroke/transient ischemic attack (TIA) within the past 3 months
- No history of seizure or any condition that may increase the patient's seizure risk (e.g., prior cortical stroke, significant brain trauma) within 2 years
- No clinically active or chronic liver disease resulting in moderate/severe hepatic impairment (Child-Pugh class B or C), ascites, coagulopathy or bleeding due to liver dysfunction
- No clinical, laboratory or radiographic evidence of an active bacterial, fungal, or viral infection requiring treatment at the time of registration
- No planned palliative procedures for alleviation of bone pain such as radiation therapy or surgery
- No untreated spinal cord compression or evidence of spinal metastases with a risk of impending fracture or spinal cord compression
- No known or suspected contraindications or hypersensitivity to enzalutamide, rucaparib, or to any of the excipients
- No known or suspected gastrointestinal disorder affecting absorption of oral medications
- No prior malignancy for which the last treatment was given within the past 2 years, or any active concurrent malignancy with the exception of non-melanomatous localized skin cancers (such as squamous or basal cell carcinoma of the skin)
- Any concomitant medications that are strong inhibitors of CYP2C8 or inducers of CYP3A4 cytochrome enzymes must be discontinued prior to registration. Dose adjustments per Food and Drug Administration (FDA) label or clinical judgement should be considered for any concomitant medications that are moderate inhibitors of CYP2C8 or inducers of CYP3A4 cytochrome enzymes
- Any concomitant medications that are substrates of CYP3A4, CYP2C9 and CYP2C19 cytochrome enzymes should be monitored closely per clinical judgement of the treating physician
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Arm I (enzalutamide, rucaparib)
Patients receive enzalutamide PO QD and rucaparib PO BID.
Patients who did not undergo bilateral orchiectomy also receive ADT consisting of leuprolide acetate IM, goserelin acetate SC every 12 weeks or degarelix SC.
Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
|
Ancillary studies
Ancillary studies
Given PO
Given SC
Given PO
Given IM
Given SC
|
Active Comparator: Arm II (enzalutamide, placebo)
Patients receive enzalutamide PO QD and placebo PO BID.
Patients who did not undergo bilateral orchiectomy also receive ADT consisting of leuprolide acetate IM, goserelin acetate SC every 12 weeks or degarelix SC.
Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
|
Ancillary studies
Ancillary studies
Given PO
Given SC
Given IM
Given PO
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Radiographic progression-free survival (rPFS)
Time Frame: Up to 5 years post treatment
|
Radiographic progression-free survival (rPFS) is defined as the time from randomization to date of disease progression or death due to any cause.
rPFS time will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 5 years post treatment
|
Overall survival (OS)
Time Frame: Up to 5 years post treatment
|
Overall survival is defined as the time from randomization to death due to any cause.
Overall survival time will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 5 years post treatment
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Radiographic progression-free survival (rPFS) within HRRm status
Time Frame: Up to 5 years post treatment
|
Defined as the time from randomization to date of disease progression or death due to any cause.
rPFS time will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 5 years post treatment
|
Time to unequivocal clinical progression
Time Frame: Up to 5 years post treatment
|
Defined as deterioration in clinical status clearly attributable to prostate cancer progression with occurrence of cancer pain requiring initiation of chronic administration of opiate analgesia, or an immediate need to re-initiate cytotoxic chemotherapy, radiation therapy or surgical intervention for disease-progression related events; or deterioration of Eastern Cooperative Oncology Group (ECOG) performance status to 3 or greater.
Time to unequivocal clinical progression will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 5 years post treatment
|
Overall survival by HRRm status
Time Frame: Up to 5 years post treatment
|
Defined as the time from randomization to death due to any cause.Overall survival time will be compared between the treatment arms using a stratified (by HRRm status) log-rank test.
Median times per treatment arms/HRRm status will be reported.
|
Up to 5 years post treatment
|
Overall response rate
Time Frame: Up to 1 year after completion of treatment
|
Defined as confirmed radiographic complete response or partial response.
The proportion of patients with confirmed radiographic response or partial response will be compared between the treatment arms with a chi-square test (or Fisher's exact test if more appropriate).
|
Up to 1 year after completion of treatment
|
Duration of overall response
Time Frame: Up to 1 year after completion of treatment
|
Defined as the time from documentation of a radiographic response to disease progression.
Duration of response time will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 1 year after completion of treatment
|
Prostate specific antigen (PSA) response rate
Time Frame: Up to 1 year after completion of treatment
|
Defined as >= 50% reduction in PSA from baseline.
The proportion of patients with PSA response will be compared between the treatment arms with a chi-square test (or Fisher's exact test if more appropriate).
|
Up to 1 year after completion of treatment
|
Best response by serum prostate specific antigen (PSA)
Time Frame: At 7 and 13 months from the start of treatment
|
Defined as best percentage PSA decline from baseline to 7 and 13 months.
The percent PSA decline will be compared between treatment arms with a Wilcoxon rank sum test.
|
At 7 and 13 months from the start of treatment
|
Time to first symptomatic skeletal event (SSE)
Time Frame: Up to 5 years after completion of treatment
|
Defined as the time to first use of external-beam radiation therapy to relieve skeletal symptoms, new symptomatic pathologic vertebral or nonvertebral bone fractures, spinal cord compression, or tumor-related orthopedic surgical intervention.
Time to first SSE will be compared between the treatment arms using a log-rank test.
Median times per treatment arms will be reported.
|
Up to 5 years after completion of treatment
|
Incidence of adverse events
Time Frame: Up to 1 year after completion of treatment
|
Frequency as measured by National Cancer Institute (NCI) Common Toxicity Criteria.
The proportion of patients experiencing at least one grade 3+ adverse event will be compared between the treatment arms with a chi-square test (or Fisher's exact test if more appropriate).
|
Up to 1 year after completion of treatment
|
Discontinuation for treatment emergent toxicities
Time Frame: Up to 1 year after completion of treatment
|
The proportion of patients who discontinued treatment for emergent toxicities will be compared between the treatment arms with a chi-square test (or Fisher's exact test if more appropriate).
|
Up to 1 year after completion of treatment
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Quality of life
Time Frame: 12 months
|
Measured by change from baseline to 12 months of the Trial Outcome Index of the Functional Assessment of Cancer Therapy-Prostate (FACT-P) patient-reported outcome questionnaire.
|
12 months
|
Quality of life
Time Frame: 12 months
|
Measured by change from baseline to 12 months of the Utility Score of the European Quality of Life Five Dimension Five Level (EQ-5D-5L) patient-reported outcome questionnaire.
|
12 months
|
Laboratory correlative science
Time Frame: Up to 1 year after completion of treatment
|
Area under curve for plasma-based and tissue-based genomic profiling in detection of HRRm in mCRPC.
|
Up to 1 year after completion of treatment
|
Laboratory correlative science
Time Frame: Up to 1 year after completion of treatment
|
The proportion of patients with homologous-recombination repair (HRR) alterations at baseline who develop HRR reversion/function restoring alterations after initiation of treatment in each arm with a chi-square test (or Fisher's exact test if more appropriate).
|
Up to 1 year after completion of treatment
|
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Arpit Rao, MD, Baylor College of Medicine
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Genital Neoplasms, Male
- Prostatic Diseases
- Urogenital Diseases
- Male Urogenital Diseases
- Genital Diseases, Male
- Genital Diseases
- Prostatic Neoplasms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Poly(ADP-ribose) Polymerase Inhibitors
- Reproductive Control Agents
- Fertility Agents, Female
- Fertility Agents
- Leuprolide
- Goserelin
- Rucaparib
Other Study ID Numbers
- A031902
- U10CA180821 (U.S. NIH Grant/Contract)
- NCI-2020-02360 (Registry Identifier: NCI Clinical Trial Reporting Program)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Castration-Resistant Prostate Carcinoma
-
Universität des SaarlandesRecruitingProstate Cancer Metastatic | Advanced Prostate Carcinoma | Castration Resistant Prostatic CancerGermany
-
Vadim S KoshkinEli Lilly and Company; Prostate Cancer FoundationActive, not recruitingCastration-Resistant Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Metastatic Castration-resistant Prostate Cancer | Metastatic Prostate Adenocarcinoma | Metastatic Castration-resistant Prostate CarcinomaUnited States
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Nuvation Bio Inc.WithdrawnProstate Cancer | Prostate Neoplasm | Cancer of the Prostate | Prostatic Cancer | Castrate Resistant Prostate Cancer | Cancer of Prostate | Castration Resistant Prostatic Cancer | Castration Resistant Prostatic NeoplasmsUnited States
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Janux TherapeuticsRecruitingProstate Cancer | Metastatic Castration-resistant Prostate Cancer | Castration Resistant Prostatic CancerUnited States, Australia
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Fred Hutchinson Cancer CenterNational Cancer Institute (NCI); Cancer Immunotherapy Trials NetworkCompletedCastration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IV Prostate Cancer | Castration Levels of TestosteroneUnited States
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Astellas Pharma IncPfizerCompletedCastration-resistant Prostate CancerJapan
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Myovant Sciences GmbHRecruitingMetastatic Castration-Resistant Prostate Cancer | Metastatic Castration-Sensitive Prostate Cancer | Non-Metastatic Castration-Resistant Prostate CancerUnited States
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Dana-Farber Cancer InstituteProgenics Pharmaceuticals, Inc.Not yet recruitingProstate Cancer | Metastatic Castration-resistant Prostate Cancer | Metastatic Castration-resistant Prostate CarcinomaUnited States
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Barbara Ann Karmanos Cancer InstituteNational Cancer Institute (NCI)UnknownCastration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8 | Castration Levels of Testosterone | Prostate Carcinoma Metastatic in the BoneUnited States
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University of WashingtonNational Cancer Institute (NCI)CompletedCastration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Recurrent Prostate Carcinoma | Castration Levels of Testosterone | Stage IV Prostate AdenocarcinomaUnited States
Clinical Trials on Quality-of-Life Assessment
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Wake Forest University Health SciencesNational Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol Specific | Malignant NeoplasmUnited States
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Children's Oncology GroupNational Cancer Institute (NCI)RecruitingChildhood Malignant NeoplasmUnited States, Canada, Puerto Rico, Australia, New Zealand
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Gynecologic Oncology GroupNational Cancer Institute (NCI)CompletedOvarian Clear Cell Cystadenocarcinoma | Ovarian Endometrioid Adenocarcinoma | Ovarian Seromucinous Carcinoma | Ovarian Serous Cystadenocarcinoma | Stage IV Ovarian Germ Cell Tumor | Ovarian Sarcoma | Malignant Ovarian Epithelial Tumor | Ovarian Carcinosarcoma | Ovarian Brenner Tumor | Ovarian Mucinous... and other conditionsUnited States
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Wake Forest University Health SciencesWithdrawnLung Metastases | Extensive Stage Small Cell Lung Cancer | Recurrent Small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Recurrent Malignant Mesothelioma | Advanced Malignant Mesothelioma
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City of Hope Medical CenterNational Cancer Institute (NCI)Recruiting
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingHematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | COVID-19 InfectionUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingHematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | COVID-19 InfectionUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingHematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Neuropathy | COVID-19 InfectionUnited States
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M.D. Anderson Cancer CenterActive, not recruitingCervical Carcinoma | Endometrial Carcinoma | Vaginal Carcinoma | Malignant Female Reproductive System Neoplasm | Vulvar CarcinomaUnited States
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Academic and Community Cancer Research UnitedNational Cancer Institute (NCI)Active, not recruitingMetastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Stage IIIA Colorectal Cancer AJCC v8 | Stage IIIB Colorectal Cancer AJCC v8 | Stage IIIC Colorectal Cancer AJCC v8 and other conditionsUnited States