Impact of Long Distance Mountain Race on Knee Cartilage. (UT4M2020)

March 25, 2022 updated by: University Hospital, Grenoble

Assessment of the Impact of an Ultratrail on the Knee Cartilage by Using T2 MRI: a Pilot Study

Long-distance mountain running is increasingly popular among European and North America countries. Long-distance races are organized in various mountains and can reach up to 160 km (100 miles) with several thousands meters of climbing. The pathophysiological consequences of such extreme effort is still a matter a debate. From a muskelo-skeletal perspectives, the potential lower-limb join damage is a major health issue. The present study aims to use objective magnetic resonance imaging (MRI) techniques to describe the consequences of performing long-distance mountain running races on the knee cartilage.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Healthy male runners will perform T2 MRI knee cartilage examination before, immediatly after and 1 month after 3 distinct long-distance mountain races of 40, 55 and 160 km. The physiological responses during the races (speed, heart rate, glycemia) will also be recordered.

Study Type

Observational

Enrollment (Actual)

54

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Grenoble, France, 38000
        • Doutreleau

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Sampling Method

Probability Sample

Study Population

Healthy male runners

Description

Inclusion Criteria:

  • no cardiac, respiratory or neuromuscular diseases
  • more than 2 years of experience in mountain race
  • no contre-indication for participating in a mountain race

Exclusion Criteria:

  • history of knee surgery
  • contre-indication to MRI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
UT4M 40
athletes participating to the 40 km mountain race.
Other: Long-distance mountain running
Impact of a mountain race on the knee cartilage
UT4M 160
athletes participating to the 160 km mountain race.
Other: Long-distance mountain running
Impact of a mountain race on the knee cartilage
UTV 55
athletes participating to the 55 km mountain race.
Other: Long-distance mountain running
Impact of a mountain race on the knee cartilage

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
T2 MRI
Time Frame: from before to immediatly after the long-distance race
Change in T2 relaxation time of the knee cartilage
from before to immediatly after the long-distance race

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Heart rate
Time Frame: Continuous measurement during the race
Mean heart rate during the race
Continuous measurement during the race
Glycemia
Time Frame: Continuous measurement during the race
Mean glycemia during the race
Continuous measurement during the race

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Grenoble

Investigators

  • Principal Investigator: stephane Doutreleau, MD, PhD, University Hospital, Grenoble

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 3, 2020

Primary Completion (Actual)

August 31, 2021

Study Completion (Actual)

December 31, 2021

Study Registration Dates

First Submitted

September 3, 2020

First Submitted That Met QC Criteria

September 3, 2020

First Posted (Actual)

September 10, 2020

Study Record Updates

Last Update Posted (Actual)

March 28, 2022

Last Update Submitted That Met QC Criteria

March 25, 2022

Last Verified

March 1, 2022

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • UT4M 2020 - 38RC20.008

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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