- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04552028
Respiratory Dysfunction in Acute Pancreatitis (SAFI) (SAFI)
Correlation of Non-invasive and Invasive Oxygenation for the Diagnosis of Respiratory Dysfunction in Acute Pancreatitis
Acute pancreatitis (AP) is an inflammatory process of the pancreas and is one of the main causes of hospital admission of gastrointestinal origin. The annual incidence is between 13 to 45 per 100,000 habitants. The etiology may correspond to vesicular gallstones, excessive alcohol consumption, drugs, among others. Risk factors such as smoking and type 2 diabetes mellitus have been found to increase the risk of pancreatitis by 1.86 to 2.89 times.
Pulmonary complications are the most frequent in this group of patients, approximately in 75% of cases, they vary from hypoxemia to acute respiratory distress syndrome (ARDS). In the first 2 days of hospital admission, tachypnea, mild respiratory alkalosis and hypoxemia may occur, usually without radiological manifestations, however 33% of patients with AP have pulmonary complications with symtoms and radiological signs, some of them are atelectasis (15%), small pleural effusion (4-17%) mainly of right lung and pulmonary edema (8-50%).
Non-invasive methods would allow faster identification of patients with hypoxemia or patients who have pulmonary organ failure. (6) There is no evidence on the usefulness of SpO2 / FiO2 (SF) as a predictor of hypoxemia and its correlation with PaO2 / FiO2 in acute pancreatitis, however its continuous calculation can greatly reduce arterial gas intake and decrease adverse events and costs.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Basal period
Patients will be managed based on the most current acute pancreatitis clinical guidelines and the requirements will be:
- Complete medical history including: sex, age, history of chronic degenerative diseases, pulmonary and/or cardiac diseases, alcohol consumption, onset of abdominal pain, body mass index.
- Laboratory tests: blood count, biochemical profile, amylase and serum lipase, complete serum electrolytes, lipid profile, arterial blood gases.
Image studies:
- Ultrasound of the upper abdomen to rule out biliary etiology
- Computed tomography of simple abdomen in case of diagnostic doubt
- Chest radiography
- Pulse oximetry with Finger Pulse Oximeter Brand: Carejoy Model G11002
Severity of acute pancreatitis as follows:
- Severity will be established based on the revised Atlanta 2012 Criteria.
- The modified Marshall system will be evaluated to determine organic failure, which is defined as: ≥ 2 points in any of the 3 organic systems evaluated (renal, cardiovascular and pulmonary).
- Variables will be obtained to determine systemic inflammatory response syndrome.
Intervention Arterial blood gases will be taken to calculate the PF ratio at admission and every 24 hours, until the resolution of pancreatitis and/or the first 5 days of admission.
Pulse oximetry will be performed at the same time as arterial blood gases, to calculate the SP ratio at admission and every 24 hours, until resolution of pancreatitis and/or the first 5 days of hospitalization.
Treatment The management of pancreatitis upon admission will be based on the established clinical guidelines: Hartman IV solution at 20 mL/kg and subsequently infusion at 3 mL/kg/h for the first 24 hours.
Follow up
According to the state of severity of acute pancreatitis, the following groups will be formed:
- Mild: Without multiple organic failure or ARDS
- Moderately severe or ARDS <48 hours
- Severe or ARDS> 48 hours
To assess respiratory dysfunction, 2 groups will be formed:
- No respiratory dysfunction: PF> 300
- Respiratory dysfunction: PF <300
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Tolaque Aldana
- Phone Number: +528132322204
- Email: pattytolaque@gmail.com
Study Contact Backup
- Name: Joel O Jaquez Quintana, M.D.
- Phone Number: +528114183484
- Email: jomjaqui@hotmail.com
Study Locations
-
-
Nuevo León
-
Monterrey, Nuevo León, Mexico, 64460
- Recruiting
- Hospital Universitario Jose Eleuterio Gonzalez
-
Contact:
- Yolanda P Tolaque Aldana, M.D.
- Phone Number: +528132322204
- Email: pattytolaque@gmail.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients diagnosed with acute pancreatitis with clinical, radiological or laboratory criteria.
- All genders
- Acute pancreatitis of any aetiology
- Over 18 years old
Exclusion Criteria:
- Lung diseases
- Heart failure
- Cholangitis
- Acute cholecystitis
- Pregnancy
- Refuse to participate
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To determine if the SpO2 / FIO2 ratio has a correlation with PaO2 / FIO2 ratio to identify respiratory compromise in acute pancreatitis.
Time Frame: 5 days
|
Pulse oximetry will be performed at the same time as arterial blood gases, to calculate the SP ratio at admission and every 24 hours, until resolution of pancreatitis and/or the first 5 days of hospitalization.
|
5 days
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Yolanda P Toalque Aldana, M.D, Hospital Univesitario
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- GA19-00011
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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