Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam (AIMANT)

March 2, 2026 updated by: Valérie LAURENT, Central Hospital, Nancy, France
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

720

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • France
      • Nancy, France, 5400
        • Recruiting
        • CHRU de Nancy
        • Contact:
          • Valerie Laurent, Md, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria for all subjects :

  • to be over 18 year-old,
  • to be able to understand the instructions given,
  • to be enrolled in a social security plan,
  • to have underwent a pre-inclusion medical examination,
  • to give a written consent.

Inclusion Criteria especially for Patients :

  • to perform a MRI examination of the head, neck, spine, thorax, abdomen, pelvis, retroperitoneum, lower limbs, upper limbs or whole body during clinical follow-up care.

Exclusion Criteria for all subjects :

  • any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ),
  • subject under a measure of legal protection.

Exclusion Criteria especially for Healthy Subjects :

  • to have a pathology in the anatomical area to be imaged
  • to be employed by the CHRU of Nancy or having the slightest link of subordination with the CHRU of Nancy.

Exclusion Criteria especially for Patients :

  • to have a limited MRI examination time due to a sensitive clinical situation (sedation, unstable hemodynamic state, postoperative).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: All subjects will have an MRI examination
Other: MRI examination
All subjects (healthy subjects and patients) will have an MRI examination with optimized sequences

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Image quality based on standard imaging quality criteria.
Time Frame: 6 months after the last inclusion
The image quality will be appreciated visually at least by a radiologist or a researcher.
6 months after the last inclusion

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).
Time Frame: 6 months after the last inclusion
Signal to Noise Ratio will be measured in arbitrary units.
6 months after the last inclusion
Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).
Time Frame: 6 months after the last inclusion
Contrast to Noise Ratio will be measured in arbitrary units.
6 months after the last inclusion
Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence).
Time Frame: 6 months after the last inclusion
Time acquisition will be evaluated in minutes.
6 months after the last inclusion
Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence).
Time Frame: 6 months after the last inclusion
Absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale.
6 months after the last inclusion
Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence).
Time Frame: 6 months after the last inclusion
Spatial resolution will be measured in mm².
6 months after the last inclusion
Qualification of the MRI acquisition for a clinical study.
Time Frame: 6 months after the inclusion
Validation of MRI acquisition by a centralized review center.
6 months after the inclusion
Evaluation of intra-subject reproducibility on the same MRI and on two MRIs.
Time Frame: 6 months after the last inclusion
Measurement of intra-subject reproducibility on the same MRI and on two MRIs by the intra-class correlation coefficient for quantitative measurement or by the kappa coefficient for a qualitative measurement.
6 months after the last inclusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 4, 2020

Primary Completion (Estimated)

December 8, 2027

Study Completion (Estimated)

December 1, 2028

Study Registration Dates

First Submitted

November 16, 2020

First Submitted That Met QC Criteria

November 20, 2020

First Posted (Actual)

November 27, 2020

Study Record Updates

Last Update Posted (Actual)

March 4, 2026

Last Update Submitted That Met QC Criteria

March 2, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • 2020-A01969-30

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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