HBM4003 Combine With Toripalimab in Patients With Advanced NEN and Other Solid Tumors Study

An Open-Label, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 in Combination With Toripalimab in Patients With Advanced NEN and Other Solid Tumors

To select RP2D/MTD of HBM4003 in combination with Toripalimab in dose confirmation part(Part 1) and use the RP2D in dose expansion part (Part 2) to evaluate the safety, tolerability, PK/PD and preliminary efficacy of in patients with advanced NEN and other solid tumors

Study Overview

• Status: Not yet recruiting
• Conditions: Solid Tumors
• Intervention / Treatment: Drug: HBM4003; Drug: Toripalimab

Detailed Description

Subjects will be treated with HBM4003 in combination with Toripalimab for up to 2 years or until confirmed disease progression, unacceptable tolerability or treatment discontinuation through withdrawal of consent occurs, whichever happens first.

This trial consists of:

• A screening period: 28 days
• A treatment period: no longer than 2 years (Part 1 dose escalation study or Part 2 dose expansion)
• A post-treatment follow-up period, including 28 days and 84 days after the last dose of study drug;
• Survival follow-up.

• Study Type: Interventional
• Enrollment (Anticipated): 61
• Phase: Phase 1

Contacts and Locations

• Study Contact: Name: Di Yang, Bachelor; Phone Number: +86 15810330409; Email: di.yang@harbourbiomed.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. Males or females aged ≥ 18 years at the time of signing the informed consent form. For Part 1 of this study, the subjects should be ≤ 75 years of age.
2. Patients for Part 1: patients histopathologically diagnosed with advanced or recurrent solid tumors.
3. For Part 2 of the study, Patients with non- functional metastatic neuroendocrine tumor confirmed by histopathology.
4. Patients must be able to provide archived tumor tissues after latest treatment or fresh tumor tissues and relevant pathology report.
5. Patients whose estimated survival time is more than 3 months.
6. Patients with at least one measurable lesion at baseline according to RECIST (Version 1.1). The lesion had not previously received surgery, radiotherapy and/or local treatment.
7. Patients with Eastern Cooperative Oncology Group(ECOG) performance status score ≤1.
8. Every woman or man with potential fertility needs to use an effective contraceptive method during the study, up to within 3 months after last drug administration.
9. Willing and able to comply with study-specified visits schedule, treatment plan, laboratory examination and other study procedures.

Exclusion Criteria:

1. Patients who are simultaneously participating in another clinical study.
2. Patients with a history of severe allergic diseases, a history of severe drug allergies, and known or suspected allergy to macromolecular protein preparations or HBM4003 or Toripalimab or its excipients.

3. Previous and concomitant drugs or treatments to be excluded like:

   • Anti-CTLA4 drug;
   • For part 1, anti-PD1 anti-PDL1 or anti-PDL2 treatment was received within 8 weeks prior to the start of the study;
   • For part 2, patients received anti-PD1, anti-PDL1 or anti-PDL2 treatment during the relapse or metastasis stage, and the time from the last treatment is short than 12 months before the first dose;
   • Received other antitumor treatment (including chemotherapy, radiation, targeted therapy, or biotherapy), antitumor vaccine, chinese herbal medicine or proprietary medicine with anti-tumor effect, Immunosuppressant or glucocorticoid, Transfusion of PLT or RBC prior to initiation of study treatment;
   • live attenuated vaccine was received before study administration or planned during the study period.
4. Insufficient recovery from previous treatments.
5. Diseases that may affect the efficacy and safety of the investigational product, including but not limited to active infection, active autoimmune disease or autoimmune disease, primary immunodeficiency disease, any clinically significant cardiovascular disease, severe pulmonary insufficiency, organ transplantation, etc.
6. A history of other malignant diseases within 5 years before the first dose.
7. Symptomatic, active, or urgent treatment-requiring central nervous system (CNS) metastasis with imaging evidence (based on CT or MRI assessment).
8. Subjects with pleural effusion, pericardial effusion, or ascites that could not be stabilized by repeated drainage or other methods were determined by investigator.
9. Patients who the investigator believes may have other factors that will affect the efficacy or safety evaluation of this study (e.g., mental disorders, alcoholism, drug use, etc.).
10. Women who are pregnant or breastfeeding, or who plan to become pregnant during the study period and within 3 months after the last administration of the investigational product.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: HBM4003 and Toripalimab; HBM4003 combined with Toripalimab in patients with advanced NEN and other solid tumors	Drug: HBM4003; Subjects will be treated with HBM4003 on Day 1 during each 21-day cycle.; Drug: Toripalimab; Subjects will be treated with Toripalimab on Day 1 during each 21-day cycle.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Part 1: DLT	Number of subjects with DLT in each dose cohort within 1 cycle (21 days) after the first drug administration	approximate 21 days
Part 1: MTD	The maximum tolerated dose (MTD) of HBM4003 combined with Toripalimab	approximate 21 days
Part 1: RP2D	The recommended phase 2 dose (RP2D) of HBM4003 combined with Toripalimab	approximate 21 days
Part 2: ORR	Proportion of subjects with complete response (CR) and partial response (PR)	maximum 2 years

Collaborators and Investigators

• Sponsor: Harbour BioMed (Guangzhou) Co. Ltd.
• Investigators: Principal Investigator: Lin Shen, Ph.D, Peking University Cancer Hospital & Institute

Study record dates

Study Major Dates

• Study Start (Anticipated): January 20, 2022
• Primary Completion (Anticipated): October 17, 2023
• Study Completion (Anticipated): June 3, 2024

Study Registration Dates

• First Submitted: December 8, 2021
• First Submitted That Met QC Criteria: December 8, 2021
• First Posted (Actual): December 22, 2021

Study Record Updates

• Last Update Posted (Actual): January 18, 2022
• Last Update Submitted That Met QC Criteria: January 12, 2022
• Last Verified: November 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: 4003.6

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No