Rural South and Southeast Asia Household Health Survey (SEACTN-HHS)

Overview of Disease Burden in Rural South and Southeast Asia: A Cross-sectional Household Health Survey With Questionnaire Interviews and Selected Laboratory Tests

A cross-sectional household survey with two-stage cluster-randomized sampling. This cross-sectional household survey design to recruit a random sample of households that is representative for each of the study sites. From the selected households, all consenting, household members will be included in the study.

This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z

Study Overview

• Status: Completed
• Conditions: Infections; Risk Factors; Health Status; Noncommunicable Disease

Detailed Description

371 households will be randomly selected from each site in Bangladesh, Cambodia, Myanmar, and Thailand. Assuming each household has an average of 4.5 members and all members will be sampled, 1500 participants will be recruited per site. This sample size allows for the overall prevalence estimation of key survey indicators with 95% confidence and 5% degree of precision.

The survey components include questionnaire interview, physical examination, blood sample collection, and point of care (PoC) tests. The questionnaire interview will collect information on household characteristics, members' disability, presence or history of disease, risk factors, self-perceived quality of life, and health seeking behaviour. For women, questions about reproductive health and antenatal care, and for young children, vaccination coverage and achievement of child development goals, will also be assessed.

For physical examinations, tympanic temperature, weight and height will be measured in all household members, mid-upper arm circumference in young children, and blood pressure in adults. Blood sample will be collected from all participants aged 6 months and above. Venous blood samples will be collected from participants aged 5 years and older, and dried blood spot will be collected from children under 5 years. Samples will be shipped to a central laboratory and analysed. Haemoglobin PoC will be administered to all participants.

All data will be collected directly on an electronic case report form using tablets, and uploaded to an electronic database.

• Study Type: Observational
• Enrollment (Actual): 4747

Contacts and Locations

• Study Contact: Name: Yoel Lubell, Professor; Phone Number: +66-857201350; Email: Yoel@tropmedres.ac
• Study Contact Backup: Name: Meiwen Zhang, Dr.; Email: Meiwen@tropmedres.ac

Study Locations

• Bangladesh
  • Dhaka, Bangladesh, 1212
    • BangladeshBuilding Resources Across Communities (BRAC)
• Cambodia
  • Battambang, Cambodia
    • Cambodia Action for Health Development (AHEAD)
• Myanmar
  • Yangon, Myanmar, 11201
    • Medical Action Myanmar (MAM)
• Thailand
  • Chiang Rai, Thailand, 57000
    • Chiangrai Clinical Research Unit (CCRU)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Households located in the survey villages and identified in the household list are eligible for the survey. All members of the randomly selected households will be recruited

Description

Inclusion Criteria:

• All members of the selected households at the time of the survey; and able to provide informed consent.

Exclusion Criteria:

• Adults or children whose parent/guardian/ caretaker are unable or unwilling to provide informed consent.

Study Plan

How is the study designed?

Design Details

• Observational Models: Ecologic or Community
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
members of selected households at the time of survey; 371 households will be randomly selected from each site in Bangladesh, Cambodia, Myanmar, and Thailand. Assuming each household has an average of 4.5 members and all members will be sampled, 1500 participants will be recruited per site.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Prevalence of long-lasting antibodies (IgG) against selected causes of non-malaria febrile illnesses	Upon enrollment
Prevalence of Plasmodium spp. by PCR	Upon enrollment
Prevalence of chronic Hepatitis B and C	Upon enrollment
Prevalence of selected non-communicable diseases (e.g. diabetes, chronic obstructive pulmonary diseases, stroke) according to self-reported disease history and laboratory tests	Upon enrollment
Prevalence of reported disability	Upon enrollment
Lifetime prevalence of reported injury or death caused by an accident	Upon enrollment
Self-rated overall health status	Upon enrollment
Questionnaire evaluation of health-related quality of life	Upon enrollment
Prevalence of self-reported tobacco, alcohol, and other substitute use among the population aged 15 and above	Upon enrollment
Prevalence of underweight and overweight, raised blood pressure and total cholesterol	Upon enrollment

Secondary Outcome Measures

Outcome Measure	Time Frame
Evaluation of household wealth quartile according to self-reported household characteristics	Upon enrollment
Education level, marital status, and occupation	Upon enrollment
Self-reported health-related household characteristics (e.g. household cooking fuel, source of drinking water, possession of mosquito net)	Upon enrollment
Proportion of population self-reported having sought for medical care in the past month, and care providers visited	Upon enrollment
Self-reported antenatal care coverage among women who have ever given birth	Upon enrollment
Reported vaccination coverage among children < 3 years	Upon enrollment
Prevalence of reported exclusive breast feeding among children < 5 years	Upon enrollment
Prevalence of children aged 3-4 years who have reached early child development milestones, reported by caretaker	Upon enrollment
Presence of self-reported symptoms or diagnosed illness besides the outcome measures of the primary objectives	Upon enrollment
Reported illness in the last month and type of illness	Upon enrollment
Prevalence of IgM antibodies against selected acute non-malaria causes of febrile illness	Upon enrollment

Collaborators and Investigators

• Sponsor: University of Oxford
• Collaborators: Mahidol Oxford Tropical Medicine Research Unit; Chiang Rai Clinical Research Unit, Thailand; Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Bangladesh Rural Advancement Committee, Dhaka, Bangladesh; Cambodia Action for Health Development (AHEAD)
• Investigators: Principal Investigator: Yoel Lubell, Professor, Mahidol Oxford Tropical Medicine Research Unit; Principal Investigator: Thomas Peto, PhD, Mahidol Oxford Tropical Medicine Research Unit

Publications and helpful links

General Publications

• Chandna A, Chew R, Shwe Nwe Htun N, Peto TJ, Zhang M, Liverani M, Brummaier T, Phommasone K, Perrone C, Pyae Phyo A, Sattabongkot J, Roobsoong W, Nguitragool W, Sen A, Ibna Zaman S, Sandar Zaw A, Batty E, Waithira N, Abdad MY, Blacksell SD, Bodhidatta L, Callery JJ, Fagnark W, Huangsuranun W, Islam S, Lertcharoenchoke S, Lohavittayavikant S, Mukaka M, Moul V, Kumer Neogi A, Nedsuwan S, Pongvongsa T, Ponsap P, Richard-Greenblatt M, Schilling WHK, Thaipadungpanit J, Tripura R, Dondorp AM, Mayxay M, White NJ, Nosten F, Smithuis F, Ashley EA, Maude RJ, Day NPJ, Lubell Y. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project. Wellcome Open Res. 2022 Mar 10;6:64. doi: 10.12688/wellcomeopenres.16393.2. eCollection 2021.

Helpful Links

• Related Info

Study record dates

Study Major Dates

• Study Start (Actual): October 3, 2022
• Primary Completion (Actual): December 10, 2023
• Study Completion (Actual): December 10, 2023

Study Registration Dates

• First Submitted: May 19, 2022
• First Submitted That Met QC Criteria: May 19, 2022
• First Posted (Actual): May 25, 2022

Study Record Updates

• Last Update Posted (Estimated): February 28, 2024
• Last Update Submitted That Met QC Criteria: February 27, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: Cross-sectional household survey
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Noncommunicable Diseases
• Other Study ID Numbers: HCR21013

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: With participant's consent, clinical data and results from blood analyses stored in the database may be shared according to the terms defined in the MORU data sharing policy with other researchers to use in the future.
• IPD Sharing Time Frame: After completion of survey activities and reporting
• IPD Sharing Access Criteria: MORU Data Sharing Policy

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No