Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

May 21, 2026 updated by: Bonnie Halpern-Felsher, Stanford University
The Stanford Tobacco Prevention Toolkit is a free online curriculum developed for use by educators and health professionals in providing tobacco-specific prevention education to middle and high school students. A set of lessons focused on e-cigarette/vaping prevention education specifically is called the Be Vape Free curriculum. The aims of this study are to determine: (1) whether the Be Vape Free curriculum is effective in increasing middle and high school students' resistance to using tobacco and in decreasing positive attitudes towards and intentions to use e-cigarettes; (2) whether the Curriculum is effective in changing middle and high school students' actual use of tobacco; and (3) Examine heterogenous treatment effects identifying groups that benefit the most and those who do not benefit at all from the intervention.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

2779

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Palo Alto, California, United States, 94304
        • Stanford University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

10 years to 20 years (Child, Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Middle school and high school students receiving health education at schools participating in the study

Exclusion Criteria:

None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Receives Stanford vaping prevention curriculum (pilot phase)
Stanford vaping prevention curriculum is administered as pilot arm preceding main experimental intervention.
Behavioral: Stanford Vaping Prevention curriculum
Stanford vaping prevention curriculum delivered as a 5-session course administered in a school classroom setting.
Experimental: Receives Stanford vaping prevention curriculum (randomized phase)
Stanford vaping prevention curriculum is administered.
Behavioral: Stanford Vaping Prevention curriculum
Stanford vaping prevention curriculum delivered as a 5-session course administered in a school classroom setting.
No Intervention: Does not receive Stanford vaping prevention curriculum (randomized phase)
Receives another curriculum or no vaping prevention education.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in e-cigarette use
Time Frame: Change from baseline to follow-up at approximately 156 weeks
Investigator-originated survey measures (questions) assess ever e-cigarette use & past 30-day tobacco use. This outcome measure assesses e-cigarette use.
Change from baseline to follow-up at approximately 156 weeks
Change in intention to use of e-cigarettes scaled score as measured by investigator-originated survey
Time Frame: Change from baseline to follow-up at approximately 156 weeks
This survey measures change in intention to use e-cigarettes with questions related to the participant's knowledge of and resistance to use of e-cigarettes.
Change from baseline to follow-up at approximately 156 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Stanford University

Collaborators

National Cancer Institute (NCI)

Investigators

  • Principal Investigator: Bonnie Halpern-Felsher, Ph.D., Stanford University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 19, 2022

Primary Completion (Actual)

May 8, 2026

Study Completion (Actual)

May 8, 2026

Study Registration Dates

First Submitted

August 6, 2022

First Submitted That Met QC Criteria

August 6, 2022

First Posted (Actual)

August 9, 2022

Study Record Updates

Last Update Posted (Actual)

May 27, 2026

Last Update Submitted That Met QC Criteria

May 21, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 61965
  • 1R01CA263121 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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