- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05624996
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer
Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer
Study Overview
Status
Conditions
Intervention / Treatment
- Drug: Carboplatin
- Drug: Etoposide
- Other: Quality-of-Life Assessment
- Other: Questionnaire Administration
- Drug: Cisplatin
- Drug: Paclitaxel
- Biological: Durvalumab
- Drug: Pemetrexed
- Radiation: Stereotactic Body Radiation Therapy
- Radiation: Image Guided Radiation Therapy
- Procedure: Positron Emission Tomography
- Procedure: Computed Tomography
Detailed Description
PRIMARY OBJECTIVES:
I. To compare the overall survival in patients with stage II-IIIC inoperable node-positive non-small cell lung cancer (NSCLC) after image guided, motion-managed conventional radiotherapy to the primary tumor and nodal metastases (arm 1) or after image guided, motion-managed stereotactic body radiation therapy (SBRT) to the primary tumor followed by conventionally fractionated radiotherapy to nodal metastases (arm 2) both given with concurrent platinum-based chemotherapy.
II. To compare progression-free survival between the experimental arm (arm 2) and control arm (arm 1).
SECONDARY OBJECTIVES:
I. To compare objective response rate (as defined by Response Evaluation Criteria in Solid Tumors [RECIST] version [v] 1.1) between the experimental arm and control arm.
II. To compare the rate of local control between the experimental arm and control arm.
III. To compare patterns of failure (primary, locoregional, or distant) between the experimental arm and control arm.
IV. To compare changes in pulmonary function (forced expiratory volume in 1 second [FEV1] and diffusion capacity of the lung for carbon monoxide [DLCO] assessed at randomization and at 6 and 12 months following completion of radiation therapy) between the experimental arm and control arm.
V. To compare changes in quality of life and patient-reported outcomes assessed from pre-treatment to 3 months following radiation therapy of each treatment arm.
VI. To determine acute and late toxicity profiles of each treatment arm as measured by the Common Terminology Criteria for Adverse Events (CTCAE) v5.
EXPLORATORY OBJECTIVES:
I. To characterize and compare longitudinal quality of life and patient-reported outcomes of each treatment arm.
II. To collect biospecimens at baseline, after SBRT (for arm 2 patients), during last 2 weeks of chemoradiation, and after first dose of consolidation therapy, to allow for future analyses.
III. To collect 4-dimensional (4D) computed tomography (CT) planning scans and radiation dose to calculate regional lung ventilation and explore pre-treatment 4D-CT based ventilation to predict pulmonary toxicity.
IV. To characterize clinical outcomes, toxicities and changes in pulmonary function and quality of life among patients receiving proton and photon radiotherapy.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients undergo conventional IGRT and receive standard of care chemotherapy consisting of paclitaxel intravenously (IV) and carboplatin IV or pemetrexed IV and carboplatin IV or etoposide IV and cisplatin IV or pemetrexed IV and cisplatin IV and then receive durvalumab IV on study. Patients also undergo CT and/or positron emission tomography (PET)/CT during follow up.
ARM II: Patients undergo SBRT and conventional IGRT and receive standard of care chemotherapy consisting of paclitaxel IV and carboplatin IV or pemetrexed IV and carboplatin IV or etoposide IV and cisplatin IV or pemetrexed IV and cisplatin IV and then receive durvalumab IV on study. Patients also undergo CT and/or PET/CT during follow up.
Study Type
Enrollment (Estimated)
Phase
- Phase 3
Contacts and Locations
Study Locations
-
-
Arizona
-
Phoenix, Arizona, United States, 85004
- Recruiting
- Cancer Center at Saint Joseph's
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 602-406-0777
- Email: Research-cancerinstitute@dignityhealth.org
-
Tucson, Arizona, United States, 85719
- Recruiting
- Banner University Medical Center - Tucson
-
Contact:
- Site Public Contact
- Email: UACC-IIT@uacc.arizona.edu
-
Principal Investigator:
- Charles C. Hsu
-
Tucson, Arizona, United States, 85719
- Recruiting
- University of Arizona Cancer Center-North Campus
-
Contact:
- Site Public Contact
- Email: UACC-IIT@uacc.arizona.edu
-
Principal Investigator:
- Charles C. Hsu
-
-
California
-
Bakersfield, California, United States, 93301
- Recruiting
- AIS Cancer Center at San Joaquin Community Hospital
-
Contact:
- Site Public Contact
- Phone Number: 661-323-4673
-
Principal Investigator:
- Luis Mariscal
-
Burlingame, California, United States, 94010
- Recruiting
- Mills-Peninsula Medical Center
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Los Angeles, California, United States, 90033
- Recruiting
- USC / Norris Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 323-865-0451
-
Principal Investigator:
- Jason C. Ye
-
Los Angeles, California, United States, 90033
- Recruiting
- Los Angeles General Medical Center
-
Principal Investigator:
- Jason C. Ye
-
Contact:
- Site Public Contact
- Phone Number: 323-865-0451
- Email: uscnorrisinfo@med.usc.edu
-
Marysville, California, United States, 95901
- Recruiting
- Fremont - Rideout Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 530-749-4400
-
Principal Investigator:
- Edward J. Kim
-
Roseville, California, United States, 95661
- Recruiting
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Roseville, California, United States, 95661
- Recruiting
- Sutter Roseville Medical Center
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Sacramento, California, United States, 95816
- Recruiting
- Sutter Medical Center Sacramento
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
San Francisco, California, United States, 94115
- Recruiting
- California Pacific Medical Center-Pacific Campus
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
San Mateo, California, United States, 94401
- Recruiting
- Mills Health Center
-
Principal Investigator:
- Christopher U. Jones
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
-
Colorado
-
Aurora, Colorado, United States, 80045
- Recruiting
- UCHealth University of Colorado Hospital
-
Contact:
- Site Public Contact
- Phone Number: 720-848-0650
-
Principal Investigator:
- Brian D. Kavanagh
-
Colorado Springs, Colorado, United States, 80909
- Recruiting
- UCHealth Memorial Hospital Central
-
Contact:
- Site Public Contact
- Phone Number: 719-365-2406
-
Principal Investigator:
- Brian D. Kavanagh
-
Colorado Springs, Colorado, United States, 80920
- Recruiting
- Memorial Hospital North
-
Contact:
- Site Public Contact
- Phone Number: 719-364-6700
-
Principal Investigator:
- Brian D. Kavanagh
-
Colorado Springs, Colorado, United States, 80907
- Recruiting
- Rocky Mountain Cancer Centers-Penrose
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 719-776-6550
- Email: ResearchTracking@Centura.Org
-
Denver, Colorado, United States, 80206
- Recruiting
- UCHealth - Cherry Creek
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Brian D. Kavanagh
-
Fort Collins, Colorado, United States, 80524
- Recruiting
- Poudre Valley Hospital
-
Contact:
- Site Public Contact
- Phone Number: 970-297-6150
-
Principal Investigator:
- Brian D. Kavanagh
-
Fort Collins, Colorado, United States, 80528
- Recruiting
- Cancer Care and Hematology-Fort Collins
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Brian D. Kavanagh
-
Greeley, Colorado, United States, 80631
- Recruiting
- UCHealth Greeley Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Brian D. Kavanagh
-
Highlands Ranch, Colorado, United States, 80129
- Recruiting
- UCHealth Highlands Ranch Hospital
-
Contact:
- Site Public Contact
- Phone Number: 720-848-0650
-
Principal Investigator:
- Brian D. Kavanagh
-
Lone Tree, Colorado, United States, 80124
- Recruiting
- UCHealth Lone Tree Health Center
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Brian D. Kavanagh
-
Loveland, Colorado, United States, 80538
- Recruiting
- Medical Center of the Rockies
-
Contact:
- Site Public Contact
- Phone Number: 970-203-7083
-
Principal Investigator:
- Brian D. Kavanagh
-
-
Delaware
-
Newark, Delaware, United States, 19713
- Recruiting
- Helen F Graham Cancer Center
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
Newark, Delaware, United States, 19713
- Recruiting
- Medical Oncology Hematology Consultants PA
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
Newark, Delaware, United States, 19718
- Recruiting
- Christiana Care Health System-Christiana Hospital
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
-
Florida
-
Clearwater, Florida, United States, 33756
- Recruiting
- Morton Plant Hospital
-
Contact:
- Site Public Contact
- Phone Number: 855-314-8646
-
Principal Investigator:
- Vijaya K. Gadiyaram
-
-
Georgia
-
Atlanta, Georgia, United States, 30322
- Recruiting
- Emory University Hospital/Winship Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 404-778-1868
-
Principal Investigator:
- Aparna Kesarwala
-
Atlanta, Georgia, United States, 30303
- Recruiting
- Grady Health System
-
Contact:
- Site Public Contact
- Phone Number: 404-489-9164
-
Principal Investigator:
- Aparna Kesarwala
-
Atlanta, Georgia, United States, 30308
- Recruiting
- Emory University Hospital Midtown
-
Contact:
- Site Public Contact
- Phone Number: 888-946-7447
-
Principal Investigator:
- Aparna Kesarwala
-
Atlanta, Georgia, United States, 30342
- Recruiting
- Emory Saint Joseph's Hospital
-
Contact:
- Site Public Contact
- Phone Number: 404-851-7115
-
Principal Investigator:
- Aparna Kesarwala
-
Atlanta, Georgia, United States, 30308
- Recruiting
- Emory Proton Therapy Center
-
Contact:
- Site Public Contact
- Phone Number: 404-251-2854
- Email: allyson.anderson@emory.edu
-
Principal Investigator:
- Aparna Kesarwala
-
-
Hawaii
-
'Aiea, Hawaii, United States, 96701
- Recruiting
- Pali Momi Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-486-6000
-
Principal Investigator:
- Michael C. Roach
-
'Aiea, Hawaii, United States, 96701
- Recruiting
- Hawaii Cancer Care - Westridge
-
Contact:
- Site Public Contact
- Phone Number: 808-539-2273
- Email: info@hawaiicancercare.com
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Contact:
- Site Public Contact
- Phone Number: 808-524-6115
- Email: i.webster@hawaiicancercare.com
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Cancer Cenrer - POB I
-
Contact:
- Site Public Contact
- Phone Number: 808-532-0315
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-545-8548
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Straub Clinic and Hospital
-
Contact:
- Site Public Contact
- Phone Number: 808-522-4333
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- University of Hawaii Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 808-586-2979
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96817
- Recruiting
- Kuakini Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-547-9816
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96817
- Recruiting
- Queen's Cancer Center - Kuakini
-
Contact:
- Site Public Contact
- Phone Number: 808-531-8521
-
Principal Investigator:
- Michael C. Roach
-
Honolulu, Hawaii, United States, 96817
- Recruiting
- The Cancer Center of Hawaii-Liliha
-
Contact:
- Site Public Contact
- Phone Number: 808-547-6881
-
Principal Investigator:
- Michael C. Roach
-
-
Illinois
-
Aurora, Illinois, United States, 60504
- Recruiting
- Rush - Copley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 630-978-6212
- Email: Cancer.Research@rushcopley.com
-
Principal Investigator:
- Sinisa Stanic
-
Barrington, Illinois, United States, 60010
- Recruiting
- Advocate Good Shepherd Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-842-4847
-
Principal Investigator:
- Jeffrey A. Kittel
-
Bloomington, Illinois, United States, 61704
- Recruiting
- Illinois CancerCare-Bloomington
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Bloomington, Illinois, United States, 61701
- Recruiting
- Saint Joseph Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Canton, Illinois, United States, 61520
- Recruiting
- Illinois CancerCare-Canton
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Carthage, Illinois, United States, 62321
- Recruiting
- Illinois CancerCare-Carthage
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Centralia, Illinois, United States, 62801
- Recruiting
- Centralia Oncology Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Chicago, Illinois, United States, 60611
- Recruiting
- Northwestern University
-
Principal Investigator:
- Mohamed E. Abazeed
-
Contact:
- Site Public Contact
- Phone Number: 312-695-1301
- Email: cancer@northwestern.edu
-
Chicago, Illinois, United States, 60657
- Recruiting
- Advocate Illinois Masonic Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 773-296-5360
-
Principal Investigator:
- Jeffrey A. Kittel
-
Crystal Lake, Illinois, United States, 60014
- Recruiting
- AMG Crystal Lake - Oncology
-
Contact:
- Site Public Contact
- Phone Number: 630-929-6129
- Email: advocateresearch@advocate.com
-
Principal Investigator:
- Jeffrey A. Kittel
-
Danville, Illinois, United States, 61832
- Recruiting
- Carle at The Riverfront
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Sinisa Stanic
-
DeKalb, Illinois, United States, 60115
- Recruiting
- Northwestern Medicine Cancer Center Kishwaukee
-
Principal Investigator:
- Mohamed E. Abazeed
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Decatur, Illinois, United States, 62526
- Recruiting
- Cancer Care Specialists of Illinois - Decatur
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Decatur, Illinois, United States, 62526
- Recruiting
- Decatur Memorial Hospital
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Effingham, Illinois, United States, 62401
- Recruiting
- Carle Physician Group-Effingham
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Sinisa Stanic
-
Effingham, Illinois, United States, 62401
- Recruiting
- Crossroads Cancer Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Elgin, Illinois, United States, 60123
- Recruiting
- Advocate Sherman Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-429-2907
-
Principal Investigator:
- Jeffrey A. Kittel
-
Eureka, Illinois, United States, 61530
- Recruiting
- Illinois CancerCare-Eureka
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Galesburg, Illinois, United States, 61401
- Recruiting
- Illinois CancerCare-Galesburg
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Geneva, Illinois, United States, 60134
- Recruiting
- Northwestern Medicine Cancer Center Delnor
-
Principal Investigator:
- Mohamed E. Abazeed
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Hazel Crest, Illinois, United States, 60429
- Recruiting
- Advocate South Suburban Hospital
-
Contact:
- Site Public Contact
- Phone Number: 708-799-9995
-
Principal Investigator:
- Jeffrey A. Kittel
-
Kewanee, Illinois, United States, 61443
- Recruiting
- Illinois CancerCare-Kewanee Clinic
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Libertyville, Illinois, United States, 60048
- Recruiting
- AMG Libertyville - Oncology
-
Contact:
- Site Public Contact
- Phone Number: 630-929-6129
- Email: advocateresearch@advocatehealth.com
-
Principal Investigator:
- Jeffrey A. Kittel
-
Libertyville, Illinois, United States, 60048
- Recruiting
- Condell Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 630-929-6129
- Email: advocateresearch@advocatehealth.com
-
Principal Investigator:
- Jeffrey A. Kittel
-
Macomb, Illinois, United States, 61455
- Recruiting
- Illinois CancerCare-Macomb
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Mattoon, Illinois, United States, 61938
- Recruiting
- Carle Physician Group-Mattoon/Charleston
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Sinisa Stanic
-
O'Fallon, Illinois, United States, 62269
- Recruiting
- Cancer Care Center of O'Fallon
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Oak Lawn, Illinois, United States, 60453-2699
- Recruiting
- Advocate Christ Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-323-8622
-
Principal Investigator:
- Jeffrey A. Kittel
-
Ottawa, Illinois, United States, 61350
- Recruiting
- Illinois CancerCare-Ottawa Clinic
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Park Ridge, Illinois, United States, 60068
- Recruiting
- Advocate Lutheran General Hospital
-
Contact:
- Site Public Contact
- Phone Number: 847-384-3621
-
Principal Investigator:
- Jeffrey A. Kittel
-
Pekin, Illinois, United States, 61554
- Recruiting
- Illinois CancerCare-Pekin
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Peoria, Illinois, United States, 61615
- Recruiting
- Illinois CancerCare-Peoria
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Peoria, Illinois, United States, 61636
- Recruiting
- Methodist Medical Center of Illinois
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Peru, Illinois, United States, 61354
- Recruiting
- Illinois CancerCare-Peru
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Princeton, Illinois, United States, 61356
- Recruiting
- Illinois CancerCare-Princeton
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
Springfield, Illinois, United States, 62702
- Recruiting
- Southern Illinois University School of Medicine
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-545-7929
-
Springfield, Illinois, United States, 62702
- Recruiting
- Springfield Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 800-444-7541
-
Springfield, Illinois, United States, 62781
- Recruiting
- Memorial Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-528-7541
- Email: pallante.beth@mhsil.com
-
Urbana, Illinois, United States, 61801
- Recruiting
- Carle Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Sinisa Stanic
-
Warrenville, Illinois, United States, 60555
- Recruiting
- Northwestern Medicine Cancer Center Warrenville
-
Principal Investigator:
- Mohamed E. Abazeed
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Washington, Illinois, United States, 61571
- Recruiting
- Illinois CancerCare - Washington
-
Contact:
- Site Public Contact
- Phone Number: 309-243-3605
- Email: andersonj@illinoiscancercare.com
-
Principal Investigator:
- Bryan A. Faller
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Recruiting
- Mary Greeley Medical Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Ames, Iowa, United States, 50010
- Recruiting
- McFarland Clinic - Ames
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-239-4734
- Email: ksoder@mcfarlandclinic.com
-
Ankeny, Iowa, United States, 50023
- Recruiting
- Mission Cancer and Blood - Ankeny
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-282-2921
-
Clive, Iowa, United States, 50325
- Recruiting
- Medical Oncology and Hematology Associates-West Des Moines
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Des Moines, Iowa, United States, 50309
- Recruiting
- Medical Oncology and Hematology Associates-Des Moines
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Des Moines, Iowa, United States, 50314
- Recruiting
- Mission Cancer and Blood - Laurel
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Des Moines, Iowa, United States, 50309
- Recruiting
- Iowa Methodist Medical Center
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-241-6727
-
-
Kansas
-
Wichita, Kansas, United States, 67214
- Recruiting
- Ascension Via Christi Hospitals Wichita
-
Contact:
- Site Public Contact
- Phone Number: 316-291-4774
- Email: research@viachristi.org
-
Principal Investigator:
- Dennis F. Moore
-
-
Kentucky
-
Lexington, Kentucky, United States, 40536
- Recruiting
- University of Kentucky/Markey Cancer Center
-
Principal Investigator:
- Ronald C. McGarry
-
Contact:
- Site Public Contact
- Phone Number: 859-257-3379
-
-
Maryland
-
Annapolis, Maryland, United States, 21401
- Recruiting
- Anne Arundel Medical Center
-
Principal Investigator:
- Amar Rewari
-
Contact:
- Site Public Contact
- Phone Number: 443-481-1320
- Email: research@luminishealth.org
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48106
- Recruiting
- Saint Joseph Mercy Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Bay City, Michigan, United States, 48706
- Recruiting
- McLaren Cancer Institute-Bay City
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Brighton, Michigan, United States, 48114
- Recruiting
- Saint Joseph Mercy Brighton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Brighton, Michigan, United States, 48114
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Chelsea, Michigan, United States, 48118
- Recruiting
- Saint Joseph Mercy Chelsea
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Chelsea, Michigan, United States, 48118
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Clarkston, Michigan, United States, 48346
- Recruiting
- McLaren Cancer Institute-Clarkston
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Detroit, Michigan, United States, 48201
- Recruiting
- Wayne State University/Karmanos Cancer Institute
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Farmington Hills, Michigan, United States, 48334
- Recruiting
- Weisberg Cancer Treatment Center
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Flint, Michigan, United States, 48532
- Recruiting
- McLaren Cancer Institute-Flint
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Lansing, Michigan, United States, 48912
- Recruiting
- Sparrow Hospital
-
Contact:
- Site Public Contact
- Phone Number: 517-364-9400
-
Principal Investigator:
- Samir Narayan
-
Lansing, Michigan, United States, 48910
- Recruiting
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Lapeer, Michigan, United States, 48446
- Recruiting
- McLaren Cancer Institute-Lapeer Region
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Livonia, Michigan, United States, 48154
- Recruiting
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Mount Clemens, Michigan, United States, 48043
- Recruiting
- McLaren Cancer Institute-Macomb
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Petoskey, Michigan, United States, 49770
- Recruiting
- McLaren Cancer Institute-Northern Michigan
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Pontiac, Michigan, United States, 48341
- Recruiting
- 21st Century Oncology-Pontiac
-
Contact:
- Site Public Contact
- Phone Number: 734-712-3671
- Email: stephanie.couch@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Pontiac, Michigan, United States, 48341
- Recruiting
- Saint Joseph Mercy Oakland
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
Port Huron, Michigan, United States, 48060
- Recruiting
- McLaren-Port Huron
-
Principal Investigator:
- Brian K. Yeh
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Royal Oak, Michigan, United States, 48073
- Recruiting
- William Beaumont Hospital-Royal Oak
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Inga S. Grills
-
Traverse City, Michigan, United States, 49684
- Recruiting
- Munson Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 616-391-1230
- Email: crcwm-regulatory@crcwm.org
-
Principal Investigator:
- Kathleen J. Yost
-
Troy, Michigan, United States, 48085
- Recruiting
- William Beaumont Hospital - Troy
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Inga S. Grills
-
Ypsilanti, Michigan, United States, 48197
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Samir Narayan
-
-
Minnesota
-
Saint Cloud, Minnesota, United States, 56303
- Recruiting
- Coborn Cancer Center at Saint Cloud Hospital
-
Contact:
- Site Public Contact
- Phone Number: 877-229-4907
- Email: coborncancercenter@centracare.com
-
Principal Investigator:
- Donald J. Jurgens
-
-
Missouri
-
Cape Girardeau, Missouri, United States, 63703
- Recruiting
- Saint Francis Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 573-334-2230
- Email: sfmc@sfmc.net
-
Farmington, Missouri, United States, 63640
- Recruiting
- Parkland Health Center - Farmington
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 314-996-5569
-
Saint Louis, Missouri, United States, 63141
- Recruiting
- Mercy Hospital Saint Louis
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 314-251-7066
-
Saint Louis, Missouri, United States, 63131
- Recruiting
- Missouri Baptist Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 314-996-5569
-
Saint Louis, Missouri, United States, 63128
- Recruiting
- Mercy Hospital South
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 314-525-6042
- Email: Danielle.Werle@mercy.net
-
Sainte Genevieve, Missouri, United States, 63670
- Recruiting
- Sainte Genevieve County Memorial Hospital
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 314-996-5569
-
Sullivan, Missouri, United States, 63080
- Recruiting
- Missouri Baptist Sullivan Hospital
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 314-996-5569
-
Sunset Hills, Missouri, United States, 63127
- Recruiting
- BJC Outpatient Center at Sunset Hills
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 314-996-5569
-
-
Nevada
-
Reno, Nevada, United States, 89502
- Recruiting
- Renown Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 702-384-0013
- Email: research@sncrf.org
-
Principal Investigator:
- John A. Ellerton
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Recruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@dartmouth.edu
-
Principal Investigator:
- Gregory A. Russo
-
-
New Jersey
-
Basking Ridge, New Jersey, United States, 07920
- Recruiting
- Memorial Sloan Kettering Basking Ridge
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
Middletown, New Jersey, United States, 07748
- Recruiting
- Memorial Sloan Kettering Monmouth
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
Montvale, New Jersey, United States, 07645
- Recruiting
- Memorial Sloan Kettering Bergen
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
-
New York
-
Batavia, New York, United States, 14020
- Recruiting
- Wilmot Cancer Center at Batavia
-
Principal Investigator:
- Yuhchyau Chen
-
Contact:
- Site Public Contact
- Email: WCICTOresearch@urmc.rochester.edu
-
Bronx, New York, United States, 10461
- Recruiting
- Montefiore Medical Center-Einstein Campus
-
Contact:
- Site Public Contact
- Phone Number: 718-379-6866
- Email: eskwak@montefiore.org
-
Principal Investigator:
- Nitin Ohri
-
Bronx, New York, United States, 10467
- Recruiting
- Montefiore Medical Center - Moses Campus
-
Contact:
- Site Public Contact
- Phone Number: 718-379-6866
- Email: eskwak@montefiore.org
-
Principal Investigator:
- Nitin Ohri
-
Bronx, New York, United States, 10461
- Recruiting
- Montefiore Medical Center-Weiler Hospital
-
Contact:
- Site Public Contact
- Phone Number: 718-379-6866
- Email: eskwak@montefiore.org
-
Principal Investigator:
- Nitin Ohri
-
Canandaigua, New York, United States, 14424
- Recruiting
- Sands Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 585-396-6161
-
Principal Investigator:
- Yuhchyau Chen
-
Commack, New York, United States, 11725
- Recruiting
- Memorial Sloan Kettering Commack
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
Harrison, New York, United States, 10604
- Recruiting
- Memorial Sloan Kettering Westchester
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
New York, New York, United States, 10065
- Recruiting
- Memorial Sloan Kettering Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
New York, New York, United States, 10035
- Recruiting
- New York Proton Center
-
Contact:
- Site Public Contact
- Phone Number: 646-968-9031
- Email: ichoi@nyproton.com
-
Principal Investigator:
- Charles B. Simone
-
Rochester, New York, United States, 14642
- Recruiting
- University of Rochester
-
Principal Investigator:
- Yuhchyau Chen
-
Contact:
- Site Public Contact
- Phone Number: 585-275-5830
-
Rochester, New York, United States, 14620
- Recruiting
- Highland Hospital
-
Principal Investigator:
- Yuhchyau Chen
-
Contact:
- Site Public Contact
- Phone Number: 585-341-8113
-
Rochester, New York, United States, 14606
- Recruiting
- Wilmot Cancer Institute Radiation Oncology at Greece
-
Principal Investigator:
- Yuhchyau Chen
-
Contact:
- Site Public Contact
- Phone Number: 585-758-7877
-
Uniondale, New York, United States, 11553
- Recruiting
- Memorial Sloan Kettering Nassau
-
Contact:
- Site Public Contact
- Phone Number: 212-639-7592
-
Principal Investigator:
- Jacob Shin
-
Valhalla, New York, United States, 10595
- Recruiting
- Westchester Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Principal Investigator:
- Aviva Berkowitz
-
Webster, New York, United States, 14580
- Recruiting
- Wilmot Cancer Institute at Webster
-
Principal Investigator:
- Yuhchyau Chen
-
Contact:
- Site Public Contact
- Email: WCICTOresearch@urmc.rochester.edu
-
-
North Carolina
-
Albemarle, North Carolina, United States, 28002
- Recruiting
- Atrium Health Stanly/LCI-Albemarle
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Charlotte, North Carolina, United States, 28203
- Recruiting
- Carolinas Medical Center/Levine Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Charlotte, North Carolina, United States, 28204
- Recruiting
- Novant Health Presbyterian Medical Center
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Charlotte, North Carolina, United States, 28210
- Recruiting
- Atrium Health Pineville/LCI-Pineville
-
Contact:
- Site Public Contact
- Phone Number: 980-442-2000
-
Principal Investigator:
- John H. Heinzerling
-
Charlotte, North Carolina, United States, 28262
- Recruiting
- Atrium Health University City/LCI-University
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Clemmons, North Carolina, United States, 27012
- Recruiting
- Wake Forest University at Clemmons
-
Contact:
- Site Public Contact
- Phone Number: 888-716-9259
-
Principal Investigator:
- Michael K. Farris
-
Concord, North Carolina, United States, 28025
- Recruiting
- Atrium Health Cabarrus/LCI-Concord
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Gastonia, North Carolina, United States, 28054
- Recruiting
- CaroMont Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 704-834-2810
- Email: tammy.cozad@caromonthealth.org
-
Principal Investigator:
- Jeffrey G. Kuremsky
-
Huntersville, North Carolina, United States, 28078
- Recruiting
- Novant Health Cancer Institute - Huntersville
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Huntersville, North Carolina, United States, 28078
- Recruiting
- Novant Health Presbyterian Medical Center Huntersville
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Kernersville, North Carolina, United States, 27284
- Recruiting
- Novant Health Cancer Institute - Kernersville
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
Matthews, North Carolina, United States, 28105
- Recruiting
- Novant Health Cancer Institute - Matthews
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Matthews, North Carolina, United States, 28104
- Recruiting
- Levine Cancer Institute - Union West
-
Contact:
- Site Public Contact
- Phone Number: 980-442-0600
-
Principal Investigator:
- John H. Heinzerling
-
Matthews, North Carolina, United States, 28105
- Recruiting
- Matthews Radiation Oncology Center
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Monroe, North Carolina, United States, 28112
- Recruiting
- Atrium Health Union/LCI-Union
-
Contact:
- Site Public Contact
- Phone Number: 980-442-2000
-
Principal Investigator:
- John H. Heinzerling
-
Mooresville, North Carolina, United States, 28117
- Recruiting
- Novant Health Cancer Institute - Mooresville
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Mount Airy, North Carolina, United States, 27030
- Recruiting
- Novant Health Cancer Institute - Mount Airy
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
Salisbury, North Carolina, United States, 28144
- Recruiting
- Rowan Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 704-210-5000
- Email: nnechiporchik@novanthealth.org
-
Principal Investigator:
- Kevin S. Roof
-
Salisbury, North Carolina, United States, 28144
- Recruiting
- Novant Health Cancer Institute - Rowan
-
Principal Investigator:
- Kevin S. Roof
-
Contact:
- Site Public Contact
- Phone Number: 980-201-6360
- Email: kashah@novanthealth.org
-
Shelby, North Carolina, United States, 28150
- Recruiting
- Atrium Health Cleveland/LCI-Cleveland
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Statesville, North Carolina, United States, 28677
- Recruiting
- Wake Forest Baptist Health - Hematology Oncology - Statesville
-
Contact:
- Site Public Contact
- Phone Number: 704-872-3630
-
Principal Investigator:
- Michael K. Farris
-
Statesville, North Carolina, United States, 28625
- Recruiting
- Novant Health Cancer Institute - Statesville
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
Supply, North Carolina, United States, 28462
- Recruiting
- Novant Cancer Institute Radiation Oncology - Supply
-
Contact:
- Site Public Contact
- Phone Number: 910-754-4716
-
Principal Investigator:
- Rex A. Kiteley
-
Thomasville, North Carolina, United States, 27360
- Recruiting
- Novant Health Cancer Institute - Thomasville
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
Wilkesboro, North Carolina, United States, 28659
- Recruiting
- Novant Health Cancer Institute - Wilkesboro
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
Wilkesboro, North Carolina, United States, 28659
- Recruiting
- Wake Forest Baptist Health - Wilkes Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 888-716-9253
-
Principal Investigator:
- Michael K. Farris
-
Wilmington, North Carolina, United States, 28401
- Recruiting
- Novant Health New Hanover Regional Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 910-342-3000
-
Principal Investigator:
- Rex A. Kiteley
-
Wilmington, North Carolina, United States, 28401
- Recruiting
- Novant Health Cancer Institute Radiation Oncology - Wilmington
-
Contact:
- Site Public Contact
- Phone Number: 910-251-1839
-
Principal Investigator:
- Rex A. Kiteley
-
Winston-Salem, North Carolina, United States, 27157
- Recruiting
- Wake Forest University Health Sciences
-
Contact:
- Site Public Contact
- Phone Number: 336-713-6771
-
Principal Investigator:
- Michael K. Farris
-
Winston-Salem, North Carolina, United States, 27103
- Recruiting
- Novant Health Forsyth Medical Center
-
Principal Investigator:
- Volker W. Stieber
-
Contact:
- Site Public Contact
- Phone Number: 336-718-8335
- Email: asmarrs@novanthealth.org
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Recruiting
- Sanford Bismarck Medical Center
-
Principal Investigator:
- Daniel Almquist
-
Contact:
- Site Public Contact
- Phone Number: 701-323-5760
- Email: OncologyClinicalTrialsFargo@sanfordhealth.org
-
Fargo, North Dakota, United States, 58122
- Recruiting
- Sanford Broadway Medical Center
-
Principal Investigator:
- Daniel Almquist
-
Contact:
- Site Public Contact
- Phone Number: 701-323-5760
- Email: OncologyClinicalTrialsFargo@sanfordhealth.org
-
Fargo, North Dakota, United States, 58122
- Recruiting
- Sanford Roger Maris Cancer Center
-
Principal Investigator:
- Daniel Almquist
-
Contact:
- Site Public Contact
- Phone Number: 701-234-6161
- Email: OncologyClinicalTrialsFargo@sanfordhealth.org
-
Grand Forks, North Dakota, United States, 58201
- Recruiting
- Altru Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 701-780-6520
-
Principal Investigator:
- Grant R. Seeger
-
-
Ohio
-
Akron, Ohio, United States, 44307
- Recruiting
- Cleveland Clinic Akron General
-
Contact:
- Site Public Contact
- Phone Number: 866-223-8100
- Email: CancerAnswer@ccf.org
-
Principal Investigator:
- Praveen Pendyala
-
Canton, Ohio, United States, 44708
- Recruiting
- Cleveland Clinic Mercy Hospital
-
Principal Investigator:
- Edward J. Walsh
-
Contact:
- Site Public Contact
- Phone Number: 888-293-4673
-
Centerville, Ohio, United States, 45459
- Recruiting
- Miami Valley Hospital South
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45409
- Recruiting
- Miami Valley Hospital
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45415
- Recruiting
- Dayton Physician LLC-Miami Valley Hospital North
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Howard M. Gross
-
Dayton, Ohio, United States, 45415
- Recruiting
- Miami Valley Hospital North
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45409
- Recruiting
- Dayton Blood and Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 937-276-8320
-
Principal Investigator:
- Tarek M. Sabagh
-
Franklin, Ohio, United States, 45005-1066
- Recruiting
- Atrium Medical Center-Middletown Regional Hospital
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Greenville, Ohio, United States, 45331
- Recruiting
- Miami Valley Cancer Care and Infusion
-
Principal Investigator:
- Tarek M. Sabagh
-
Contact:
- Site Public Contact
- Phone Number: 937-569-7515
-
Perrysburg, Ohio, United States, 43551
- Recruiting
- Mercy Health Perrysburg Cancer Center
-
Principal Investigator:
- Timothy D. Moore
-
Contact:
- Site Public Contact
- Phone Number: 614-488-2118
- Email: sheree@columbusccop.org
-
Troy, Ohio, United States, 45373
- Recruiting
- Upper Valley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- Recruiting
- University of Oklahoma Health Sciences Center
-
Contact:
- Site Public Contact
- Phone Number: 405-271-8777
- Email: ou-clinical-trials@ouhsc.edu
-
Principal Investigator:
- Raid Aljumaily
-
-
Oregon
-
Gresham, Oregon, United States, 97030
- Recruiting
- Legacy Mount Hood Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-413-2150
-
Principal Investigator:
- Andrew Y. Kee
-
Portland, Oregon, United States, 97210
- Recruiting
- Legacy Good Samaritan Hospital and Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-220-4937
- Email: cancer@lhs.org
-
Principal Investigator:
- Andrew Y. Kee
-
Tualatin, Oregon, United States, 97062
- Recruiting
- Legacy Meridian Park Hospital
-
Contact:
- Site Public Contact
- Phone Number: 503-413-1742
-
Principal Investigator:
- Andrew Y. Kee
-
-
Pennsylvania
-
Chadds Ford, Pennsylvania, United States, 19317
- Recruiting
- Christiana Care Health System-Concord Health Center
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
Chambersburg, Pennsylvania, United States, 17201
- Recruiting
- Chambersburg Hospital
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 412-339-5294
- Email: Roster@nrgoncology.org
-
Danville, Pennsylvania, United States, 17822
- Recruiting
- Geisinger Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 570-271-5251
- Email: HemonCCTrials@geisinger.edu
-
Principal Investigator:
- Fiori Alite
-
Ephrata, Pennsylvania, United States, 17522
- Recruiting
- Ephrata Cancer Center
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 717-721-4840
-
Gettysburg, Pennsylvania, United States, 17325
- Recruiting
- Adams Cancer Center
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 877-441-7957
-
Lebanon, Pennsylvania, United States, 17042
- Recruiting
- Sechler Family Cancer Center
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 717-741-8303
- Email: doxenberg@wellspan.org
-
Lewisburg, Pennsylvania, United States, 17837
- Recruiting
- Geisinger Medical Oncology-Lewisburg
-
Contact:
- Site Public Contact
- Phone Number: 570-374-8555
- Email: HemonCCTrials@geisinger.edu
-
Principal Investigator:
- Fiori Alite
-
Philadelphia, Pennsylvania, United States, 19104
- Recruiting
- University of Pennsylvania/Abramson Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-474-9892
-
Principal Investigator:
- Jeffrey D. Bradley
-
Philadelphia, Pennsylvania, United States, 19107
- Not yet recruiting
- Thomas Jefferson University Hospital
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Maria Werner-Wasik
-
West Reading, Pennsylvania, United States, 19611
- Recruiting
- Reading Hospital
-
Contact:
- Site Public Contact
- Phone Number: 610-988-9323
-
Principal Investigator:
- Michael L. Haas
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Recruiting
- Geisinger Wyoming Valley/Henry Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 570-271-5251
- Email: HemonCCTrials@geisinger.edu
-
Principal Investigator:
- Fiori Alite
-
Willow Grove, Pennsylvania, United States, 19090
- Recruiting
- Asplundh Cancer Pavilion
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Maria Werner-Wasik
-
York, Pennsylvania, United States, 17403
- Recruiting
- WellSpan Health-York Cancer Center
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 877-441-7957
-
York, Pennsylvania, United States, 17403
- Recruiting
- WellSpan Health-York Hospital
-
Principal Investigator:
- Amit B. Shah
-
Contact:
- Site Public Contact
- Phone Number: 877-441-7957
-
-
South Carolina
-
Rock Hill, South Carolina, United States, 29732
- Recruiting
- Levine Cancer Institute-Rock Hill
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
Rock Hill, South Carolina, United States, 29730
- Recruiting
- Rock Hill Radiation Therapy Center
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Principal Investigator:
- John H. Heinzerling
-
-
South Dakota
-
Sioux Falls, South Dakota, United States, 57104
- Recruiting
- Sanford Cancer Center Oncology Clinic
-
Principal Investigator:
- Daniel Almquist
-
Contact:
- Site Public Contact
- Phone Number: 605-312-3320
- Email: OncologyClinicTrialsSF@sanfordhealth.org
-
Sioux Falls, South Dakota, United States, 57117-5134
- Recruiting
- Sanford USD Medical Center - Sioux Falls
-
Principal Investigator:
- Daniel Almquist
-
Contact:
- Site Public Contact
- Phone Number: 605-312-3320
- Email: OncologyClinicalTrialsSF@SanfordHealth.org
-
-
Texas
-
Conroe, Texas, United States, 77384
- Recruiting
- MD Anderson in The Woodlands
-
Contact:
- Site Public Contact
- Phone Number: 866-632-6789
- Email: askmdanderson@mdanderson.org
-
Principal Investigator:
- Julianna Bronk
-
Houston, Texas, United States, 77030
- Recruiting
- M D Anderson Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 877-632-6789
- Email: askmdanderson@mdanderson.org
-
Principal Investigator:
- Julianna Bronk
-
Houston, Texas, United States, 77079
- Recruiting
- MD Anderson West Houston
-
Contact:
- Site Public Contact
- Phone Number: 877-632-6789
- Email: askmdanderson@mdanderson.org
-
Principal Investigator:
- Julianna Bronk
-
League City, Texas, United States, 77573
- Recruiting
- MD Anderson League City
-
Contact:
- Site Public Contact
- Phone Number: 877-632-6789
- Email: askmdanderson@mdanderson.org
-
Principal Investigator:
- Julianna Bronk
-
Sugar Land, Texas, United States, 77478
- Recruiting
- MD Anderson in Sugar Land
-
Contact:
- Site Public Contact
- Phone Number: 877-632-6789
- Email: askmdanderson@mdanderson.org
-
Principal Investigator:
- Julianna Bronk
-
-
Vermont
-
Burlington, Vermont, United States, 05401
- Recruiting
- University of Vermont Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 802-656-4101
- Email: rpo@uvm.edu
-
Principal Investigator:
- Christopher J. Anker
-
Burlington, Vermont, United States, 05405
- Recruiting
- University of Vermont and State Agricultural College
-
Contact:
- Site Public Contact
- Phone Number: 802-656-8990
- Email: rpo@uvm.edu
-
Principal Investigator:
- Christopher J. Anker
-
Saint Johnsbury, Vermont, United States, 05819
- Recruiting
- Norris Cotton Cancer Center-North
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@hitchcock.org
-
Principal Investigator:
- Gregory A. Russo
-
-
Washington
-
Vancouver, Washington, United States, 98686
- Recruiting
- Legacy Salmon Creek Hospital
-
Contact:
- Site Public Contact
- Phone Number: 503-413-2150
-
Principal Investigator:
- Andrew Y. Kee
-
Vancouver, Washington, United States, 98684
- Recruiting
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Contact:
- Site Public Contact
- Email: oncologyresearch@lhs.org
-
Principal Investigator:
- Andrew Y. Kee
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Recruiting
- Langlade Hospital and Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 715-623-9869
- Email: Juli.Alford@aspirus.org
-
Principal Investigator:
- Andrew J. Huang
-
Burlington, Wisconsin, United States, 53105
- Recruiting
- Aurora Cancer Care-Southern Lakes VLCC
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Eau Claire, Wisconsin, United States, 54701
- Recruiting
- HSHS Sacred Heart Hospital
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Germantown, Wisconsin, United States, 53022
- Recruiting
- Aurora Health Care Germantown Health Center
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Grafton, Wisconsin, United States, 53024
- Recruiting
- Aurora Cancer Care-Grafton
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Green Bay, Wisconsin, United States, 54311
- Recruiting
- Aurora BayCare Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Green Bay, Wisconsin, United States, 54301
- Recruiting
- Saint Vincent Hospital Cancer Center Green Bay
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Johnson Creek, Wisconsin, United States, 53038
- Recruiting
- UW Cancer Center Johnson Creek
-
Contact:
- Site Public Contact
- Phone Number: 920-699-3500
- Email: lynda.persico@uwmf.wisc.edu
-
Principal Investigator:
- Andrew M. Baschnagel
-
Kenosha, Wisconsin, United States, 53142
- Recruiting
- Aurora Cancer Care-Kenosha South
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Madison, Wisconsin, United States, 53792
- Recruiting
- University of Wisconsin Carbone Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-622-8922
-
Principal Investigator:
- Andrew M. Baschnagel
-
Marinette, Wisconsin, United States, 54143
- Recruiting
- Aurora Bay Area Medical Group-Marinette
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Menomonee Falls, Wisconsin, United States, 53051
- Recruiting
- Froedtert Menomonee Falls Hospital
-
Contact:
- Site Public Contact
- Phone Number: 262-257-5100
-
Principal Investigator:
- Lindsay L. Puckett
-
Milwaukee, Wisconsin, United States, 53209
- Recruiting
- Aurora Cancer Care-Milwaukee
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Milwaukee, Wisconsin, United States, 53215
- Recruiting
- Aurora Saint Luke's Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Milwaukee, Wisconsin, United States, 53226
- Recruiting
- Medical College of Wisconsin
-
Contact:
- Site Public Contact
- Phone Number: 414-805-3666
-
Principal Investigator:
- Lindsay L. Puckett
-
Milwaukee, Wisconsin, United States, 53233
- Recruiting
- Aurora Sinai Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Milwaukee, Wisconsin, United States, 53295
- Recruiting
- Zablocki Veterans Administration Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 888-469-6614
-
Principal Investigator:
- Adam D. Currey
-
Mukwonago, Wisconsin, United States, 53149
- Recruiting
- ProHealth D N Greenwald Center
-
Contact:
- Site Public Contact
- Email: research.institute@phci.org
-
Principal Investigator:
- Timothy R. Wassenaar
-
Oak Creek, Wisconsin, United States, 53154
- Recruiting
- Drexel Town Square Health Center
-
Contact:
- Site Public Contact
- Phone Number: 414-805-0505
-
Principal Investigator:
- Lindsay L. Puckett
-
Oconomowoc, Wisconsin, United States, 53066
- Recruiting
- ProHealth Oconomowoc Memorial Hospital
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-7878
-
Oshkosh, Wisconsin, United States, 54904
- Recruiting
- Vince Lombardi Cancer Clinic - Oshkosh
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Racine, Wisconsin, United States, 53406
- Recruiting
- Aurora Cancer Care-Racine
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Rhinelander, Wisconsin, United States, 54501
- Recruiting
- Ascension Saint Mary's Hospital
-
Principal Investigator:
- Andrew J. Huang
-
Contact:
- Site Public Contact
- Phone Number: 715-847-2353
- Email: Beth.Knetter@aspirus.org
-
Sheboygan, Wisconsin, United States, 53081
- Recruiting
- Vince Lombardi Cancer Clinic-Sheboygan
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Sheboygan, Wisconsin, United States, 53081
- Recruiting
- Saint Vincent Hospital Cancer Center at Sheboygan
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Stevens Point, Wisconsin, United States, 54481
- Recruiting
- Ascension Saint Michael's Hospital
-
Principal Investigator:
- Andrew J. Huang
-
Contact:
- Site Public Contact
- Phone Number: 715-847-2353
- Email: Beth.Knetter@aspirus.org
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Recruiting
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Contact:
- Site Public Contact
- Phone Number: 920-433-8889
- Email: ewd_research_admin@hshs.org
-
Principal Investigator:
- Matthew L. Ryan
-
Summit, Wisconsin, United States, 53066
- Recruiting
- Aurora Medical Center in Summit
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
Waukesha, Wisconsin, United States, 53188
- Recruiting
- UW Cancer Center at ProHealth Care
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-5539
- Email: Chanda.miller@phci.org
-
Wausau, Wisconsin, United States, 54401
- Recruiting
- Aspirus Regional Cancer Center
-
Principal Investigator:
- Andrew J. Huang
-
Contact:
- Site Public Contact
- Phone Number: 877-405-6866
-
Wauwatosa, Wisconsin, United States, 53226
- Recruiting
- Aurora Cancer Care-Milwaukee West
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
West Allis, Wisconsin, United States, 53227
- Recruiting
- Aurora West Allis Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 414-302-2304
- Email: ncorp@aurora.org
-
Principal Investigator:
- Jeffrey A. Kittel
-
West Bend, Wisconsin, United States, 53095
- Recruiting
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 414-805-0505
-
Principal Investigator:
- Lindsay L. Puckett
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Recruiting
- Aspirus Cancer Care - Wisconsin Rapids
-
Principal Investigator:
- Andrew J. Huang
-
Contact:
- Site Public Contact
- Phone Number: 715-422-7718
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
Pathologically (histologically or cytologically) proven diagnosis of stage II or III (American Joint Committee on Cancer [AJCC] eighth edition) non-small cell lung cancer (NSCLC) with known PD-L1 status prior to registration
- Patients must have an identified primary tumor and at least one nodal metastasis (peribronchial/hilar/intrapulmonary, mediastinal/subcarinal, supraclavicular/scalene)
- Up to 4 cycles of systemic therapy received prior to registration for the current study cancer is allowable; any prior chemotherapy for a different cancer is also permissible
The patient must be deemed clinically appropriate for curative intent definitive combined modality therapy, based on the following staging assessments:
- History/physical examination prior to registration;
- Magnetic resonance imaging (MRI) scan of the brain (preferred) or CT scan of the brain (if available, contrast is preferred for all neuroimaging) prior to registration;
- CT chest with IV contrast (if contrast is available and unless contraindicated, such as for abnormal kidney function) prior to registration. PET/CT may be used if the CT portion is of identical diagnostic quality as achieved in a stand-alone CT
- No evidence of distant metastases based on FDG PET/CT scan obtain within 60 days of registration
- Primary tumor =< 7 cm
- Age >= 18
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Hematologic function (e.g. platelets, leukocytes, hemoglobin) amenable, at the discretion of the treating physician, to allow for treatment with chemotherapy and concurrent radiation therapy
- Creatinine clearance >= 25 mL/min by the Cockcroft-Gault (C-G) equation
Subjects with non-malignant pleural effusion are eligible provided the effusion is not known or demonstrated to be an exudative effusion
If a pleural effusion is present, the following criteria must be met to exclude malignant involvement:
- When pleural fluid is visible on both the CT scan and on a chest x-ray, a pleuracentesis is required to confirm that the pleural fluid is cytologically negative;
- Effusions that are minimal (i.e., not visible on chest x-ray) that are too small to safely tap are eligible
- Medical history consistent with the patient being amenable, at the discretion of the treating physician, to allow for treating with consolidation immunotherapy. Patients with known EGFR/ALK mutation at the time of registration are eligible, and these patients can be treated with consolidation durvalumab or chemotherapy at the discretion of the treating physician
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen
- Negative pregnancy test =< 14 days prior to registration for participants of childbearing potential
- The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
Exclusion Criteria:
- Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields that is determined by the treating physician to impede the treatment of the study malignancy
- Patients without identifiable primary tumor and at least 1 pathologically enlarged lymph node are not eligible (T3-4N0 or T0N1-3 patients are not eligible). At least 1 radiographically-involved lymph node is required, but pathologic confirmation of involvement is not mandated
- Centrally located primary tumor < 2 cm from involved nodal disease which would result in significant overlap of the primary SBRT and nodal radiation fields. Centrally located is defined as within or touching the zone of the proximal bronchial tree, which is a volume 2 cm in all directions around the proximal bronchial tree (carina, right and left main bronchi, right and left upper lobe bronchi, intermedius bronchus, right middle lobe bronchus, lingular bronchus right and left lower lobe bronchi)
- Participants who are pregnant or unwilling to discontinue nursing
- Participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy and for the Food and Drug Administration (FDA)-labeled contraception timeframe required after the final dose of the selected chemotherapy regimen, because the treatment in this study may be significantly teratogenic
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Arm I (image guided RT, chemotherapy, immunotherapy)
Patients undergo conventional IGRT and receive standard of care chemotherapy consisting of paclitaxel IV and carboplatin IV or pemetrexed IV and carboplatin IV or etoposide IV and cisplatin IV or pemetrexed IV and cisplatin IV and then receive durvalumab IV on study.
Patients also undergo CT and/or PET/CT during follow up.
|
Given IV
Other Names:
Given IV
Other Names:
Ancillary studies
Other Names:
Ancillary studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo IGRT
Other Names:
Undergo PET/CT
Other Names:
Undergo CT and/or PET/CT
Other Names:
|
Experimental: Arm II (SBRT, image guided RT, chemotherapy, immunotherapy)
Patients undergo SBRT and conventional IGRT and receive standard of care chemotherapy consisting of paclitaxel IV and carboplatin IV or pemetrexed IV and carboplatin IV or etoposide IV and cisplatin IV or pemetrexed IV and cisplatin IV and then receive durvalumab IV on study.
Patients also undergo CT and/or PET/CT during follow up.
|
Given IV
Other Names:
Given IV
Other Names:
Ancillary studies
Other Names:
Ancillary studies
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo SBRT
Other Names:
Undergo IGRT
Other Names:
Undergo PET/CT
Other Names:
Undergo CT and/or PET/CT
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall Survival (OS)
Time Frame: Between date of randomization and date of death due to any cause, assessed up to 8 years
|
Non-inferiority (NI) between arm 2 and arm 1 (reference level) will be evaluated by comparing the upper bound of the 95% confidence interval for the hazard ratio to the pre-specified NI margin.
NI of arm 2 will be concluded if the upper bound of the confidence interval is equal to, or falls below, the pre-specified margin at the final analysis.
When evaluating the NI of arm 2 in OS, a Cox proportional hazards (PH) model stratified by stratification factors will be used to compute the hazard ratio and associated 95% confidence interval (CI).
OS rates will be estimated using the Kaplan-Meier method.
If the NI of arm 2 in OS is demonstrated, the superiority of arm 1 in OS will be tested at 1-sided significance level of 0.025 using a stratified log-rank test by adjusting for stratification factors.
|
Between date of randomization and date of death due to any cause, assessed up to 8 years
|
Progression-Free Survival (PFS)
Time Frame: Between date of randomization and first date of documented progression or death due to any cause, assessed up to 8 years
|
The PFS analysis will be conducted using the same methods and stratification factors as the OS analysis.
The superiority of arm 2 in PFS will be tested at 1-sided significance level of 0.025 using a stratified log-rank test by adjusting for stratification factors.
In the event that the NI of OS is not established, statistical inference of PFS will be considered exploratory in nature only.
A Cox PH model stratified by stratification factors will be used to compute the hazard ratio and associated 95% CI.
|
Between date of randomization and first date of documented progression or death due to any cause, assessed up to 8 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Objective Response Rate (ORR)
Time Frame: Up to 8 years
|
ORR (per Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) is defined as the number (%) of patients with at least 1 visit response of complete response (CR) or partial response (PR) and will be based on all randomized patients who have measurable disease.
Therefore, data obtained up until progression, or the last evaluable assessment in the absence of progression, will be included in the assessment of ORR.
The ORR will be compared between arm 2 versus arm 1 using a Fisher's exact test.
A binary response variable for ORR will be used for the analysis with the categories of CR and PR versus stable disease (SD), progressive disease (PD) and inevaluable (NE).
|
Up to 8 years
|
Time to progression
Time Frame: Up to 8 years
|
Local control will be defined as freedom from local progression, in which a failure is defined as intrathoracic tumor progression (failure in the lobe of the primary tumor or mediastinal lymph nodes) by RECIST 1.1 criteria.
Local control will be analyzed as competing risks data based on cause-specific hazards approaches, where deaths without local failure will be considered as a competing event and analyzed as "censoring" of local failure.
The rates at various timepoints (e.g., every 6 months after randomization) and medians of PFS for each arm will be estimated using the Kaplan-Meier method.
The associated 95% CI will be calculated using Greenwood's formula and based on a log-log transformation applied on the survival function.
Results from an unstratified analysis will also be provided.
|
Up to 8 years
|
Time to primary, locoregional, or distant failure
Time Frame: Up to 8 years
|
Competing risks analysis will be used to analyze times to primary failure, locoregional failure and distant failure as the first failure.
Competing events include primary failure, locoregional failure, distant failure and deaths without any failures.
Rates at various timepoints (i.e., every 6 months after randomization) for each arm will be estimated using the cumulative incidence function.
The associated 95% CI will be calculated using the Delta method and based on a log-log transformation applied on the estimated cumulative incidence functions.
Statistical inferences of the development of each failure between arms will be based on cause-specific hazards using the log-rank test and Cox proportional hazard model.
In addition, Gray's test and the Fine-Gray model will also be used to provide statistical inferences between arms based on cumulative incidence functions and subdistribution hazards.
|
Up to 8 years
|
Changes in pulmonary function
Time Frame: From randomization to 6 months or 12 months
|
Includes forced expiratory volume in 1 second (FEV1) and diffusion capacity of the lung for carbon monoxide (DLCO).
Changes in pulmonary function (FEV1 and DLCO) will be summarized with descriptive statistics, and compared with Wilcoxon rank-sum test.
The descriptive statistics of changes in FEV1 and diffusion capacity before and after treatment will be reported by treatment arm and by response categories (complete response; partial response; stable disease; progressive disease).
Linear regression will be used to model changes with adjustment for treatment arms and possibly other baseline covariates, if applicable.
The grade 3-5 NRG Oncology Pulmonary Toxicity Scale for changes will be reported with the frequency and grade by arm.
Logistic regression will be used to model the distribution of the NRG Oncology Pulmonary Toxicity Scale by arms with and without adjustment for covariates.
|
From randomization to 6 months or 12 months
|
Patient Reported Outcomes
Time Frame: At 3, 12, and 24 months
|
Functional Assessment of Cancer Therapy Lung Questionnaire trial outcome index deterioration rates at 3 months and associated 95% confidence interval will be calculated for each treatment group, based on all randomized subjects.
Clopper-Pearson method will be used for calculating 95% CI.
The deterioration rates of each arm will also be compared using Cochran-Mantel-Haenszel Test, stratified by PD-L1 expression and T-stage.
|
At 3, 12, and 24 months
|
Incidence of adverse events
Time Frame: Up to 8 years
|
For each patient, the maximum severity reported will be used in the summaries.
Adverse events will be summarized regardless of relationship to protocol treatment as assessed by the investigator.
Treatment-related adverse events using National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) will be presented in statistical analysis reports/publications in CTCAE version 5. Adverse event rates will be reported with the frequency and severity (e.g., type, grade, and attribution) by arm.
|
Up to 8 years
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional mean lung dose
Time Frame: Up to 8 years
|
Collection of 4 dimensional (4D) CT planning CTs and calculation of radiation dose to regional lung ventilation will be performed among randomized patients with 4D CT planning CTs.
To evaluate functional dose metrics, ventilation maps will be registered to the average 4DCT reference frame.
Functional dose metrics and standard dose metrics will be calculated and evaluated.
Functional mean lung dose will be defined as the mean dose delivered to functional lung.
Dose to total lung and dose to functional lung will then be correlated with pulmonary toxicity including grade 2 or higher radiation pneumonitis or any grade 3 or higher cough, dyspnea, hypoxia or respiratory failure.
Logistic regression models will be used to explore the correlation between pulmonary toxicity and functional mean lung dose.
|
Up to 8 years
|
Incidence of toxicities
Time Frame: Up to 8 years
|
Descriptive analyses will be reported, based on corresponding analysis plans within patients who actually receive proton and photon radiotherapy (e.g., per-protocol population), respectively.
|
Up to 8 years
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Charles B Simone, NRG Oncology
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Respiratory Tract Diseases
- Neoplasms
- Lung Diseases
- Neoplasms by Site
- Respiratory Tract Neoplasms
- Thoracic Neoplasms
- Carcinoma, Bronchogenic
- Bronchial Neoplasms
- Lung Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Nucleic Acid Synthesis Inhibitors
- Enzyme Inhibitors
- Antineoplastic Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Phytogenic
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Antineoplastic Agents, Immunological
- Dermatologic Agents
- Keratolytic Agents
- Folic Acid Antagonists
- Carboplatin
- Etoposide
- Etoposide phosphate
- Paclitaxel
- Cisplatin
- Podophyllotoxin
- Immunoglobulins
- Durvalumab
- Albumin-Bound Paclitaxel
- Antibodies, Monoclonal
- Pemetrexed
- Immunoglobulin G
Other Study ID Numbers
- NRG-LU008 (Other Identifier: CTEP)
- U10CA180868 (U.S. NIH Grant/Contract)
- NCI-2022-08263 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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