Associations of Lipid Measures With Premature Myocardial Infarction: a Cross-sectional Study

Acute myocardial infarction (AMI) is the first cardiovascular cause of death that seriously threatens human health worldwide. Its incidence rate and mortality are increasing year by year and becoming younger. According to statistics, the average age of men and women with AMI for the first time is 65.6 years old and 72 years old respectively, of which 4%~10% AMI occurred before 45 years old. At present, there is no uniform age threshold for young AMI. Generally speaking, AMI with onset age less than 55 years for men and 65 years for women is called early-onset AMI, accounting for 5%~13% of AMI. Compared with elderly patients with AMI, patients with early onset AMI have different risk factors, clinical characteristics and prognosis, such as lower proportion of patients with diabetes and hypertension, more single vessel lesions and rare left main artery involvement, and higher long-term recurrence rate and mortality. Although the progress of preventive measures and treatment methods has reduced the hospitalization rate of elderly AMI patients, the number of young AMI patients in hospital is still rising. Therefore, in-depth analysis of the characteristics of risk factors of early onset AMI and early intervention are of great significance to reduce the risk of onset and improve long-term prognosis.

Hyperlipidemia is an independent risk factor for coronary heart disease at all ages, and is more closely related to early onset AMI. It is reported that more than 50% of early onset AMI patients are accompanied by hyperlipidemia. However, at present, the research on the relationship between blood lipids and early onset AMI is limited to the comparison of the level of single lipid component between early onset AMI and different control groups, or the comparative analysis of the relationship between a specific lipid component and the risk of early onset AMI with young healthy people. There is no research to compare the correlation between various lipid components and the risk of early onset AMI. Therefore, this study plans to deeply analyze the correlation between different blood lipid components and their ratios and early onset AMI, and further analyze which blood lipid indicators are most closely related to early onset AMI through large sample clinical research data, taking late onset AMI patients as the control, which should be paid early attention to and strictly managed.

Study Overview

• Status: Enrolling by invitation
• Conditions: Lipid Disorder; Premature Myocardial Infarction
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Anticipated): 5000

Contacts and Locations

Study Locations

• China
  • Heilongjiang
    • Harbin, Heilongjiang, China, 150001
      • The First Affiliated Hospital Of Harbin Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

AMI patients who completed coronary angiography in the First Affiliated Hospital of Harbin Medical University from September 1, 2021 to September 31, 2022 were included consecutively to establish an AMI research queue. Baseline information such as demographic information, medical history information and laboratory examination results were collected through the electronic medical record system.

Description

Inclusion Criteria:

• According to the fourth Universal Definition of Myocardial Infarction (2018), the clinical diagnosis was acute myocardial infarction (AMI), including type 1, 2, 3, 4b and 4c.
• Complete coronary angiography
• Complete biochemical and blood lipid tests

Exclusion Criteria:

• Recurrent AMI
• The onset of AMI exceeds 7 days
• Continuous taking of lipid-lowering drugs ≥ 5 days
• Patients with missing data

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
premature myocardial infarction; AMI with onset age less than 55 years for men and 65 years for women.	Other: No intervention; This is a post-hoc analysis of a cross-sectional study.
control; AMI with onset age not less than 55 years for men and 65 years for women.	Other: No intervention; This is a post-hoc analysis of a cross-sectional study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The correlation between different blood lipid components and early onset AMI.	1 day

Collaborators and Investigators

• Sponsor: Yue LI

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2022
• Primary Completion (Anticipated): December 31, 2023
• Study Completion (Anticipated): June 30, 2024

Study Registration Dates

• First Submitted: December 2, 2022
• First Submitted That Met QC Criteria: December 2, 2022
• First Posted (Estimate): December 9, 2022

Study Record Updates

• Last Update Posted (Estimate): December 9, 2022
• Last Update Submitted That Met QC Criteria: December 2, 2022
• Last Verified: December 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Metabolic Diseases; Pregnancy Complications; Obstetric Labor Complications; Obstetric Labor, Premature; Myocardial Infarction; Infarction; Premature Birth; Lipid Metabolism Disorders
• Other Study ID Numbers: lipid and PMI

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No