Effect of Intraoperative Allogeneic Blood Transfusion on Postoperative Pulmonary Complications

Effect of Intraoperative Allogeneic Blood Transfusion on Postoperative Pulmonary Complications in Elective Spinal Surgery: a Retrospective Cohort Study

Elective spine surgery is associated with a high incidence of perioperative complications, including peri- and postoperative pulmonary complications (PPCs), which occur in nearly 4% of patients. More than 40% of all deaths after elective spine surgery are attributed to PPCs. However, whether it influences risk of other PPCs is unclear.

Study Overview

• Status: Completed
• Conditions: Spinal Fusion; Pulmonary Complication; Transfusion
• Intervention / Treatment: Procedure: transfusion

• Study Type: Observational
• Enrollment (Actual): 272

Contacts and Locations

Study Locations

• China
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310000
      • The Second Affiliated Hospital of Zhejiang University anesthesiology department

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 years to 78 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients were included if they underwent post vertebral column resection (e.g. multi-segmental thoracic, lumbar, or thoracolumbar spine surgery) at the Second Hospital of Zhejiang University School of Medicine from August 1, 2013 to October 31, 2020

Description

Inclusion Criteria:

• Patients were included if they underwent elective spine surgery (e.g. multi-segmental thoracic, lumbar, or thoracolumbar spine surgery) at the Second Hospital of Zhejiang University School of Medicine from August 1, 2013 to October 31, 2020

Exclusion Criteria:

• combined anterior-posterior surgery
• growth rod adjustment surgery
• spinal tumor.
• surgery took fewer than 3 hours.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Retrospective

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
non-PPCs group; Patients without PPCs (Pleural effusion, Pulmonary atelectasis, Pulmonary infection)	Procedure: transfusion; transfusion
PPCs group; Patients with PPCs (Pleural effusion, Pulmonary atelectasis, Pulmonary infection)	Procedure: transfusion; transfusion

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Correlation between blood transfusion and postoperative pulmonary complications	Correlation between blood transfusion and postoperative pulmonary complications	28 days after surgery

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Investigators: Study Chair: Min Yan, doctor, The Second Affiliated Hospital of Zhejiang University Medical College

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2013
• Primary Completion (Actual): October 31, 2020
• Study Completion (Actual): October 31, 2020

Study Registration Dates

• First Submitted: December 15, 2022
• First Submitted That Met QC Criteria: December 21, 2022
• First Posted (Estimate): December 22, 2022

Study Record Updates

• Last Update Posted (Estimate): December 22, 2022
• Last Update Submitted That Met QC Criteria: December 21, 2022
• Last Verified: August 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: 2022-0968

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No