Urinary Tract Infection in Patients With Chronic Kidney Disease

Urinary Tract Infection in Patients With Chronic Kidney Disease: A Retrospective Observational Study at Outpatient Nephrology Clinics

This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen.

Study Overview

• Status: Completed
• Conditions: Chronic Kidney Diseases; Urinary Tract Infections
• Intervention / Treatment: Other: Patients with urinary tract infection and chronic kidney disease

Detailed Description

Chronic kidney disease (CKD) patients are at higher risk of urinary tract infections (UTI), as CKD is a state of chronic inflammation, metabolic disturbance and impaired immunocompetence. Moreover, patient with CKD are usually of advanced age and suffer from other comorbidities such as diabetes, hypertension, obesity, and cardiovascular diseases, which also add to their risk of infection.

UTI comprises heterogeneous conditions ranging from mild cystitis, easily treated with oral antibiotics, to life-threatening sepsis and multiple organ failure.

There is scarce information about risk factors of recurrence of UTI and infection with multidrug-resistant organisms in the Egyptian population.

• Study Type: Observational
• Enrollment (Actual): 250

Contacts and Locations

Study Locations

• Egypt
  • Alexandria, Egypt
    • Faculty of medicine, Alexandria University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients will be recruited from outpatient nephrology clinics in Alexandria.

Description

Inclusion Criteria:

1. Males and non-pregnant females aged ≥ 18 years old
2. Patients with CKD stages (G1 to G4)
3. Patients diagnosed with UTI due to urine culture

Exclusion Criteria:

1. Non-CKD patients
2. pregnant females
3. CKD patients on immunosuppressant agents
4. ESRD patients on hemodialysis
5. Patients with structural abnormalities which make them liable to frequent UTI

Study Plan

How is the study designed?

Design Details

• Observational Models: Other
• Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
prevalence of UTI in CKD patients	percentage of UTI in CKD patients	records will be retrospectively screened from January 2019 till September 2022
isolated microorganisms causing UTI in CKD patients	isolated microorganisms in cultures causing UTI in CKD patients	records will be retrospectively screened from January 2019 till September 2022

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
sensitivity pattern of urine cultures in CKD	describe sensitivity pattern of urine cultures in CKD	records will be retrospectively screened from January 2019 till September 2022

Collaborators and Investigators

• Sponsor: Alexandria University
• Investigators: Principal Investigator: mohamed mamdouh elsayed, MD, Lecturer of Nephrology & Internal Medicine, Faculty of medicine, Alexandria University; Study Chair: Mohammed Abdel Gawad, Nephrology Lecturer, School of Medicine, New Giza University (NGU), Giza, Egypt; Study Chair: Dalia Elzayat, Faculty of Pharmacy, Pharos University, Alexandria, Egypt; Study Chair: Reham Mekawy, Faculty of Pharmacy, Pharos University, Alexandria, Egypt; Study Chair: Salma Mahdy, Faculty of Pharmacy, Pharos University, Alexandria, Egypt; Study Chair: Salma Imam, Faculty of Pharmacy, Pharos University, Alexandria, Egypt; Study Chair: Hala Abo El-hassan, Faculty of Pharmacy, Pharos University, Alexandria, Egypt; Study Chair: Ramy Elwaraky, Department of Clinical Pharmacy, Kidney and Urology Center, Alexandria, Egypt; Study Chair: Engy Emam, Clinical Pharmacist, Alexandria Main University Hospital, Alexandria, Egypt

Publications and helpful links

General Publications

• Scherberich JE, Funfstuck R, Naber KG. Urinary tract infections in patients with renal insufficiency and dialysis - epidemiology, pathogenesis, clinical symptoms, diagnosis and treatment. GMS Infect Dis. 2021 Dec 21;9:Doc07. doi: 10.3205/id000076. eCollection 2021.
• Gouda Z, Mashaal G, Bello AK, El Attar A, El Kemmry T, El Reweny A, El Nahas M. Egypt Information, Prevention, and Treatment of Chronic Kidney Disease (EGIPT-CKD) programme: prevalence and risk factors for microalbuminuria among the relatives of patients with CKD in Egypt. Saudi J Kidney Dis Transpl. 2011 Sep;22(5):1055-63.
• Dimitrijevic Z, Paunovic G, Tasic D, Mitic B, Basic D. Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections. Sci Rep. 2021 Jul 13;11(1):14414. doi: 10.1038/s41598-021-93912-3.

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2023
• Primary Completion (Actual): April 15, 2024
• Study Completion (Actual): May 15, 2024

Study Registration Dates

• First Submitted: December 14, 2022
• First Submitted That Met QC Criteria: December 29, 2022
• First Posted (Actual): January 9, 2023

Study Record Updates

• Last Update Posted (Actual): June 18, 2024
• Last Update Submitted That Met QC Criteria: June 15, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Keywords: chronic kidney disease; CKD; infection; UTI; urinary tract
• Additional Relevant MeSH Terms: Pathologic Processes; Urologic Diseases; Disease Attributes; Renal Insufficiency; Chronic Disease; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Kidney Diseases; Renal Insufficiency, Chronic; Infections; Communicable Diseases; Urinary Tract Infections
• Other Study ID Numbers: Urinary Tract Infection

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No