Comparative Study of Personality in Parkinson's Disease Patients With Other Chronic Pain (PSYCHO-PAIN)

Personality and Chronic Pain: a Comparative Study in Parkinson's Disease and Other Chronic Pain Conditions

The present study compare personality of Parkinson's Disease (PD) patients with chronic, PD patients without pain and non-parkinsonian patients with other chronic pain condition.

Study Overview

• Status: Completed
• Conditions: Parkinson Disease
• Intervention / Treatment: Other: TCI; Other: BPI; Other: CPAQ-8; Other: SF-MPQ; Other: PCS; Other: ORT; Other: IPQ-R; Other: WCC-R; Other: King's Parkinson's Disease Pain Scale (KPPS); Other: Hospital Anxiety and Depression scale (HAD) questionary; Other: Social Support Questionnaire (SSQ6)

Detailed Description

The present study would like to compare personality dimensions from the Temperament and character inventory (TCI) in four groups of patients: PD patients with chronic pain related to PD, PD patients without pain and non-PD patients with chronic pain such as fibromyalgia or chronic headache. Our aim is to evaluate if PD patients with chronic pain related to PD have a different personality than PD patients without pain and to see if this personality is specific to PD.

• Study Type: Observational
• Enrollment (Actual): 100

Contacts and Locations

Study Locations

• France
  • Toulouse, France, 31059
    • Toulouse University Hospital (CHU de Toulouse)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Parkinsonian patients with and without chronic pain and non-parkinsonian patients with chronic pain such as fibromyalgia and headache

Description

Inclusion Criteria:

• PD patients:

Patients having Parkinson's disease according to UNITED KINGDOM PARKINSON'S DISEASE SOCIETY BRAIN BANK (UKPDSBB) criteria

PD patients with chronic pain:

Patients with a pain VAS score ≥ 4 (mean VAS for the last week) Patients with a chronic pain since at least 3 months

PD patients without pain:

Patients with a pain VAS score < 3

• non PD patients:

Patients with chronic headache:

Patients with chronic headache according to the ICHD-3 beta criteria Patients with a chronic pain since at least 3 months

Patients with fibromyalgia:

Patients with fibromyalgia according to the criteria of the American College of Rheumatology 2016 (Wolfe et al., 2016) Patients with a pain VAS score ≥ 4 (mean VAS for the last week) Patients with a chronic pain since at least 3 months

• All patients:

Patient > 18 years old Patient able to give its free and informed consent Patient having a social security.

Exclusion Criteria:

• PD patients:

Patients presenting atypical Parkinson's syndrome Patients having a deep brain stimulation Patients presenting a cognitive decline evaluated by a Montreal Cognitive Assessment (MoCA) score inferior to 24

• All patients:

Patient having a psychiatric disease diagnosed according to the Diagnostic and Statistical Manual-V (DSM-V) criteria such as mood disorders, psychotic disorder… None ability to give its consent Patients unable to realize the tests provided in the context of this study Patients under supervision, curatorship, or legal guardian Patients non-affiliated to a social security Patients in exclusion period of another study.

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
PD patients with chronic pain; Parkinsonian patient with pain	Other: TCI; Temperament and character inventory; Other: BPI; Brief Pain Inventory; Other: CPAQ-8; Chronic Pain Acceptance Questionnaire-8; Other: SF-MPQ; short-form McGill Pain Questionnaire; Other: PCS; Pain Catastrophism Scale; Other: ORT; Opioid Risk Tool; Other: IPQ-R; Illness Perception Questionnaire Revised; Other: WCC-R; Ways of Coping Checklist Revised; Other: King's Parkinson's Disease Pain Scale (KPPS); King's Parkinson's Disease Pain Scale; Other: Hospital Anxiety and Depression scale (HAD) questionary; Hospital Anxiety and Depression scale; Other: Social Support Questionnaire (SSQ6); Social Support Questionnaire (SSQ6) (score of availability and score of satisfaction)
PD patients without pain; Parkinsonian patient without pain	Other: TCI; Temperament and character inventory; Other: ORT; Opioid Risk Tool; Other: Hospital Anxiety and Depression scale (HAD) questionary; Hospital Anxiety and Depression scale; Other: Social Support Questionnaire (SSQ6); Social Support Questionnaire (SSQ6) (score of availability and score of satisfaction)
non-PD patients with chronic pain; Non-PD with fibromyalgia and non-PD with chronic headache	Other: TCI; Temperament and character inventory; Other: BPI; Brief Pain Inventory; Other: CPAQ-8; Chronic Pain Acceptance Questionnaire-8; Other: SF-MPQ; short-form McGill Pain Questionnaire; Other: PCS; Pain Catastrophism Scale; Other: ORT; Opioid Risk Tool; Other: Hospital Anxiety and Depression scale (HAD) questionary; Hospital Anxiety and Depression scale

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
TCI personality dimensions between the two groups of patients	compare scores of the seven TCI personality dimensions between the two groups of parkinsonian patients with or without chronic pain related to PD. This will allow to determinate if PD patients with chronic pain related to PD have a different personality than PD patients without pain	24 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
personality dimensions of the TCI and two-by-two analyses	compare personality dimensions of the TCI through two-by-two analyses between PD patients with chronic pain related to PD and patients presenting another chronic pain etiology: 1) patients with fibromyalgia, 2) patients with chronic headache. This will allow to determinate if PD patients with chronic pain have a personality specific to their PD	24 months
association between personality the seven TCI personality dimensions and different pain	determinate if there are some associations between the seven TCI personality dimensions of PD patients with chronic pain related to PD and different pain parameters: the pain intensity evaluated with the VAS (Visual Analog Scale); the functional discomfort evaluated with the BPI (Brief Pain Inventory); the acceptation of pain evaluated with the CPAQ-8 (Chronic Pain Acceptance questionnaire-8); the discriminative and affective components of pain evaluated with the SF-MPQ (short-form McGill Pain Questionnaire); the level of catastrophism evaluated with the PCS (Pain Catastrophism Scale)	24 months
association between personality the seven TCI and scores	determinate if there are some associations between the seven TCI personality dimensions of PD patients with chronic pain related to PD and different pain parameters: the pain intensity evaluated with the Visual Analog Scale (VAS); the functional discomfort evaluated with the Brief Pain Inventory (BPI); the acceptation of pain evaluated with the Chronic Pain Acceptance questionnaire-8 (CPAQ-8); the discriminative and affective components of pain evaluated with the Short-Form McGill Pain Questionnaire (SF-MPQ); the level of catastrophism evaluated with the Pain Catastrophism Scale (PCS).	24 months
association of personality dimensions of the TCI and in other patients with chronic pain etiology	determinate if there are some associations between TCI personality dimensions and these same previous parameters (VAS, BPI, CPAQ-8, SF-MPQ, PCS and ORT) in other patients with chronic pain etiology: 1) first, in patients with fibromyalgia, 2) then, in patients with chronic headache	24 months
exploratory objective	determinate if there are some associations between TCI personality dimensions in PD patients with chronic pain related to PD and PD-specific pain evaluated by the King's Parkinson's Disease Pain Scale (KPPS)	24 months

Collaborators and Investigators

• Sponsor: University Hospital, Toulouse
• Investigators: Principal Investigator: Christine BREFEL-COURBON, MD PhD, University Hospital, Toulouse

Study record dates

Study Major Dates

• Study Start (Actual): February 16, 2023
• Primary Completion (Actual): April 3, 2024
• Study Completion (Actual): April 3, 2024

Study Registration Dates

• First Submitted: November 3, 2022
• First Submitted That Met QC Criteria: February 3, 2023
• First Posted (Actual): February 6, 2023

Study Record Updates

• Last Update Posted (Actual): April 9, 2024
• Last Update Submitted That Met QC Criteria: April 5, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: Chronic pain; personality
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Parkinson Disease; Chronic Pain
• Other Study ID Numbers: RC31/22/0372

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No