Clinical Study of QSOX1 as a Biomarker for Colon Cancer

April 21, 2023 updated by: YunqiuWang, Qianfoshan Hospital

Clinical Application of Sulfhydryl Oxidase QSOX1 as a New Biomarker of Colon Cancer

The goal of this observational study is to determine whether the secreted protein QSOX1 can be used as a molecular marker for early rapid diagnosis and accurate treatment of colon cancer.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

The project mainly selects the tumor group represented by colon cancer and the corresponding healthy people as the control group, with about 100 cases in each of the two groups. Mainly collect blood and tumor tissue samples of patients, detect the expression of QSOX1 in the above samples, and explore the role in the diagnosis and prognosis evaluation of colon cancer.

Study Type

Observational

Enrollment (Anticipated)

400

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

The patients diagnosed with colon cancer for the first time admitted to the First Affiliated Hospital of Shandong First Medical University.

Description

Inclusion Criteria:

  • Colon cancer was confirmed by colonoscopic pathology.
  • No local or systemic treatment was performed before operation.
  • Complete clinical data.

Exclusion Criteria:

  • Combined with benign diseases of colon, such as ulcerative colitis, colon adenoma and colon polyp.
  • Other tumors other than colon cancer.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Tumor group
First diagnosis of colon cancer.
Diagnostic test: Diagnosis of colon cancer
Clinical diagnosis results
Control group
Healthy people.
Diagnostic test: Diagnosis of colon cancer
Clinical diagnosis results

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Detection of RNA for early rapid diagnosis of colon cancer.
Time Frame: 6 months
RT-PCR was used to detect the RNA levels of QSOX1 in the tumor and control groups.
6 months
Detection of protein for early rapid diagnosis of colon cancer.
Time Frame: 6 months
Western blotting was used to detect the protein levels of QSOX1 in the tumor and control groups.
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Qianfoshan Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

July 1, 2023

Primary Completion (Anticipated)

June 30, 2026

Study Completion (Anticipated)

December 31, 2026

Study Registration Dates

First Submitted

March 26, 2023

First Submitted That Met QC Criteria

April 21, 2023

First Posted (Actual)

April 25, 2023

Study Record Updates

Last Update Posted (Actual)

April 25, 2023

Last Update Submitted That Met QC Criteria

April 21, 2023

Last Verified

April 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • QianfoshanHwyq20230305

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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