- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05838950
HIIT Effects on Cardiometabolic Health
Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity
Study Overview
Status
Intervention / Treatment
Detailed Description
Introduction: High-intensity interval training (HIIT) compared with other traditional exercise regimens has shown to be effective in improving cardiometabolic health (as measured by lipids, blood pressure [BP], insulin sensitivity, pulse wave velocity) in overweight and obese adults. By knowing which HIIT protocol is more efficacious in improving markers of cardiometabolic disease, exercise physiologists, researchers and clinicians can properly prescribe exercise medicine to obese young adults and possibly prevent disease progression. Therefore, the primary aim of the present research is to compare the effects of 3 different HIIT protocols compared with a control group on cardiometabolic health improvement in young adults with obesity.
Participants: Participants will be randomly assigned to one of the following three groups : 1) HIIT-A (5:25 s; 1:5 ratio), 2) HIIT-B (10:50 s; 1:5 ratio), 3) HIIT-C (20:100 s; 1:5 ratio), and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of running-based HIIT programs over a 2-week training period. The variables will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the TC (i.e., measure for detraining effect).
High-Intensity Interval Training (six sessions over 2 weeks): Heart rate will be recorded - while performing a sprint running based on the wood court. The HIIT intensity will be set at 90% of the fastest baseline with 40 repetitions of 5-seconds work time, 20 repetitions of 10-seconds work time, or 10 repetitions of 20-seconds work time. All participants will perform one bout of sprint running for 5-, 10-, or 20- seconds followed by 25-second, 50-second, or 100-seconds resting. The supervisor will verbally encourage the running to inspire the sprint at "all-out" intensity. Note that a total of 200-seconds workout time is required per session.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Myong Won Seo, Ph.D
- Phone Number: 3154012723
- Email: mseo04@syr.edu
Study Contact Backup
- Name: Wonhee Cho, MS
- Phone Number: 6267270270
- Email: mseo04@syr.edu
Study Locations
-
-
New York
-
Syracuse, New York, United States, 13244
- Recruiting
- Women's Building
-
Contact:
- Departments of Exercise Science
- Phone Number: 315-443-2115
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).
Exclusion Criteria:
- Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
- Taking weight loss medication(s)
- Currently enrolled (or within previous 6 months) in a weight loss program;
- An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
- Presence of cardiac pacemaker.
- Current or anticipated participation in another research that would interfere with any of the outcomes.
- Current or anticipated pregnancy.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Control
Control group
|
Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.
|
Experimental: 5s HIIT
5s HIIT group will perform one bout of sprint running for 5-seconds followed by 25-second, resting of total 40 repetition.
|
Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.
|
Experimental: 10s HIIT
10s HIIT group will perform one bout of sprint running for 10-seconds followed by 50-second, resting of total 20 repetition.
|
Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.
|
Experimental: 20s HIIT
20s HIIT group will perform one bout of sprint running for 20-seconds followed by 100-second, resting of total 10 repetition.
|
Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Height
Time Frame: Baseline
|
Height (cm)
|
Baseline
|
Weight
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Weight (kg); Change from Baseline weight at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Body mass index
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Body mass index (kg/m2); Change from Baseline BMI at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Percentage body fat
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Percentage body fat (kg); Change from Baseline percentage body fat at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Fat mass
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Fat mass (kg); Change from Baseline fat mass at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Lean mass
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Lean mass (kg); Change from Baseline lean mass at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Systolic blood pressure
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Systolic blood pressure (SBP, mmHg); Change from Baseline SBP at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Diastolic blood pressure
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Diastolic blood pressure (DBP, mmHg); Change from Baseline DBP at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Mean arterial pressure
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Mean blood pressure (MAP, mmHg); Change from Baseline MAP at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Flow-mediated dilation
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Flow-mediated dilation (FMD, mm); Change from Baseline FMD at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Carotid-femoral Pulse Wave Velocity (cPWV)
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
cPWV (m/s); Change from Baseline cPWV at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Total cholesterol
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Total cholesterol (mg/dl); Change from Baseline TC at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
LDL-C
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
LDL-C (mg/dl); Change from Baseline LDL-C at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
HDL-C
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
HDL-C (mg/dl); Change from Baseline HDL-C at 2 week and 4 week
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Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Triglycerides
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Triglycerides (TG, mg/dl); Change from Baseline TG at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Glucose
Time Frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Glucose (mg/dl); Change from Baseline glucose at 2 week and 4 week
|
Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Joon Young Kim, Ph.D, Syracuse University, Departments of Exercise Science
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 22-010
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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