Metabolic Response to Food in Lung Cancer (METRIC)

July 1, 2025 updated by: Justin Brown, Pennington Biomedical Research Center
This goal of this study is to describe how unintentional weight loss influences fasting and post-prandial metabolic flexibility in participants with advanced non-small cell lung cancer.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

5

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70808
        • Pennington Biomedical Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The study population will include participants with non-small-cell lung cancer with varying degrees of weight loss.

Description

Inclusion Criteria:

  • Age greater than or equal to 18 years
  • Diagnosis of non-small-cell lung cancer
  • Reported weight stability or loss after cancer diagnosis
  • Body mass index less than or equal to 35 kilograms per meter squared
  • Ability to provide written informed consent
  • Willing and able to comply with all scheduled visits, treatment plans, lab tests, and other study procedure
  • Allow the collection and storage of biospecimens and data for future use

Exclusion Criteria:

  • Prior diagnosis of diabetes mellitus (type 1 or type 2)
  • Currently pregnant or breastfeeding
  • Contraindication to consuming the liquid mixed meal
  • Any medications affecting gastric motility
  • Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Respiratory quotient
Time Frame: Difference between pre- to post-prandial conditions over four hours
The respiratory quotient will be measured by indirect calorimetry before and after consumption of a liquid mixed meal
Difference between pre- to post-prandial conditions over four hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pennington Biomedical Research Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 18, 2023

Primary Completion (Estimated)

June 30, 2026

Study Completion (Estimated)

June 30, 2026

Study Registration Dates

First Submitted

June 23, 2023

First Submitted That Met QC Criteria

June 30, 2023

First Posted (Actual)

July 10, 2023

Study Record Updates

Last Update Posted (Actual)

July 4, 2025

Last Update Submitted That Met QC Criteria

July 1, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PBRC 2023-017

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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