Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery

February 16, 2026 updated by: Ibrahim Mamdouh Esmat, Ain Shams University

Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery by Supplementing Ultrasound-guided Erector Spinae Plane Block With Ketamine or Transdermal Fentanyl Patch

Erector spinae plane block (ESPB) is a novel regional block technique that was proven to have superior outcomes in relieving postoperative pain in colorectal surgeries.Ketamine enhances the impact of local anaesthetics by reducing the duration and extent of motor block while shortening the onset of sensory and motor block.Transdermal Fentanyl Patch (TFP) was better than transdermal buprenorphine in postoperative analgesia following abdominal surgeries.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

120

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Cairo, Egypt
        • Ain-Shams University Hospitals

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients undergoing laparoscopic colorectal surgery.
  • American Society of Anesthesiologists (ASA) physical status I or II.

Exclusion Criteria:

  • Known allergy to one of the study medications.
  • Skin infections at the site of the needle puncture.
  • Hepatic, renal or cardiac dysfunction.
  • Patients diagnosed with obstructive sleep apnoea

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Bupivacaine and ketamine
Other: Bupivacaine and ketamine
Bilateral erector spinae plane block (bupivacaine and ketamine)
Other: Bupivacaine and transdermal fentanyl patch
Other: Bupivacaine and transdermal fentanyl patch
Bilateral erector spinae plane block (bupivacaine) and transdermal fentanyl patch
Other: Bupivacaine
Other: Bupivacain
Bilateral erector spinae plane block (bupivacaine)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The time to first rescue analgesia after surgery (hour)
Time Frame: The first 48 hours after surgery
The time to first rescue analgesia after surgery (hour)
The first 48 hours after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ain Shams University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 5, 2023

Primary Completion (Actual)

July 22, 2025

Study Completion (Actual)

July 22, 2025

Study Registration Dates

First Submitted

August 17, 2023

First Submitted That Met QC Criteria

August 17, 2023

First Posted (Actual)

August 23, 2023

Study Record Updates

Last Update Posted (Actual)

February 18, 2026

Last Update Submitted That Met QC Criteria

February 16, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FMASU MS 416 / 2023

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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