AMT-562 in Patients With Selected Advanced Solid Tumors

First-in-Human, Phase 1 Study of AMT-562 in Patients With Advanced Solid Tumors

This is a first-in-human, non-randomized, open-label, multicenter Phase 1 study of AMT-562 in patients with advanced solid tumors.

Study Overview

• Status: Recruiting
• Conditions: Advanced Solid Tumors
• Intervention / Treatment: Drug: AMT-562

• Study Type: Interventional
• Enrollment (Estimated): 72
• Phase: Phase 1

Contacts and Locations

• Study Contact: Name: Minqi Guan; Phone Number: 86-15895820062; Email: minqi.guan@multitudetherapeutics.com

Study Locations

• Australia
  • New South Wales
    • North Ryde, New South Wales, Australia
      • Recruiting
      • Macquarie University Hospital
      • Contact: Dhanusha Sabanathan
  • Victoria
    • Malvern, Victoria, Australia
      • Recruiting
      • Cabrini Malvern Hospital
      • Contact: Prachi Bhave

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• 1. Patients must be willing and able to understand and sign the ICF, and to adhere to the study visit schedule and other protocol requirements.
• 2. Age ≥18 years (at the time consent is obtained).
• 3. Patients with histologically confirmed unresectable advanced solid tumor.
• 4. Patients who have undergone at least one systemic therapy and have radiologically or clinically determined progressive disease (PD) during or after most recent line of therapy, and for whom no further standard therapy is available, or who are intolerable to standard therapy.
• 5. Patients must have at least one measurable lesion as per RECIST version 1.1.
• 6. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• 7. Life expectancy ≥ 3 months.
• 8. Patients must have adequate organ function
• 9. Women of child bearing potential (WCBP), defined as a sexually mature woman who has not undergone surgical sterilization or who has not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months) must agree to use two effective contraceptive methods while on study treatment and for at least twelve weeks after the last dose of the IMP.
• 10. WCBP must have a negative serum pregnancy test within 7 days prior to first dose of the IMP.
• 11. Male patients must agree to use a latex condom, even if they had a successful vasectomy, while on study treatment and for at least twelve weeks after the last dose of the IMP.
• 12. Male patients must agree not to donate sperm, and female patients must agree not to donate eggs, while on study treatment and for at least 12 weeks after the last dose of the IMP.
• 13. Availability of tumor tissue sample (either an archival specimen or a fresh biopsy material) at screening.

Exclusion Criteria:

• 1. Central nervous system (CNS) metastasis.
• 2. Active or chronic skin disorder requiring systemic therapy.
• 3. History of Steven's Johnson's syndrome or toxic epidermal necrolysis syndrome.
• 4. Persistent toxicities from previous systemic anti-neoplastic treatments of Grade >1.
• 5. Systemic anti-neoplastic therapy within five half-lives or 21 days, whichever is shorter, prior to first dose of the IMP.
• 6. Radiotherapy to lung field at a total radiation dose of ≥ 20 Gy within 6 months, wide-field radiotherapy within 28 days.
• 7. Major surgery within 28 days prior to first dose of the IMP, or no recovery from side effects of such intervention.
• 8. Significant cardiac disease.
• 9. Has a history of (non-infectious) interstitial lung disease (ILD)/pneumonitis t.
• 10. History of thromboembolic or cerebrovascular events, including transient ischemic attacks, cerebrovascular accidents, deep vein thrombosis, or pulmonary emboli within six months prior to first dose of the IMP.
• 11. Acute and/or clinically significant bacterial, fungal or viral infection including hepatitis B (HBV), hepatitis C (HCV), known human immunodeficiency virus (HIV).
• 12. Administration of a live vaccine within 28 days prior to the administration of the first dose of the IMP.
• 13. Patients requiring concurrent treatment of strong inhibitors or inducers of cytochrome P450 3A or 1A2 enzyme (CYP3A or CYP1A2) within 2 weeks prior to the first dose and during the study treatment.
• 14. Known or suspected severe allergy/hypersensitivity (resulting in treatment discontinuation) to monoclonal antibodies.
• 15. Known or suspected intolerance to the components of the IMP.
• 16. Concurrent participation in another investigational therapeutic clinical trial.
• 17. Patients with known active alcohol or drug abuse.
• 18. Pregnant or breast-feeding females.
• 19. Mental or medical conditions that prevent the patient from giving informed consent or complying with the trial or other severe acute or chronic medical or psychiatric conditions or laboratory abnormality that may increase the risk associated with the study participation or the IMP administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for enrolment in this study.
• 20. Prior history of malignancy other than inclusion diagnosis within five years prior to first dose of the IMP.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Arm 1; AMT-562 Dose Escalation	Drug: AMT-562; Administered AMT-562 for injection intravenously

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
DLTs	Incidence of dose limiting toxicities	up to 24 month
AEs	Type, incidence and severity of Adverse Events	up to 24 month
SAEs	Type, incidence and severity Serious Adverse Events (SAEs)	up to 24 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Tmax	time to peak drug concentration	up to 24 month
AUC	Area Under the Curve	up to 24 month
t1/2	terminal half-life of the ADC, total antibody and free payload	up to 24 month
ADAs	Specification and quantification of anti-drug antibodies	up to 24 month
ORR	Overall response rate assessed by the investigator according to RECIST version 1.1	up to 24 month
DCR	Disease control rate assessed by the investigator according to RECIST version 1.1	up to 24 month
PFS	Progression-free survival assessed by the investigator according to RECIST version 1.1	up to 24 month
TTR	Time to response assessed by the investigator according to RECIST version 1.1	up to 24 month
DOR	Duration of response assessed by the investigator according to RECIST version 1.1	up to 24 month
Cmax	Maximum concentration (Cmax)	up to 24 month

Collaborators and Investigators

• Sponsor: Multitude Therapeutics (Australia) Pty Ltd

Study record dates

Study Major Dates

• Study Start (Actual): May 20, 2024
• Primary Completion (Estimated): December 31, 2025
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: December 21, 2023
• First Submitted That Met QC Criteria: January 8, 2024
• First Posted (Actual): January 10, 2024

Study Record Updates

• Last Update Posted (Actual): July 26, 2024
• Last Update Submitted That Met QC Criteria: July 24, 2024
• Last Verified: December 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms
• Other Study ID Numbers: AMT-562-01

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No