hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis

February 13, 2024 updated by: Postgraduate Institute of Dental Sciences Rohtak

Effect of Endodontic Treatment on Serum High Sensitivity C-reactive Protein and Complete Hemogram Indices in Patients With Cardiovascular Disease With and Without Apical Periodontitis: A Prospective Interventional Study

Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure. Systemic inflammatory burden is assessed before and after endodontic treatment.

Study Type

Interventional

Enrollment (Actual)

70

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • India
    • Haryana
      • Rohtak, Haryana, India, 124001
        • PGIDS

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Coronary artery disease patients with and without chronic pulp exposure

Exclusion Criteria:

  • Other systemic diseases
  • Antibiotics for More than 1 month
  • Smoking
  • Analgesics more than 1 week

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: CAD WITH AP
CORONARY ARTERY DISEASE WITH APICAL PERIODONTITIS
Procedure: Endodontic treatment
Root canal treatment
No Intervention: CAD WITHOUT AP
CORONARY ARTERY DISEASE WITHOUT AP

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Serum hsCRP
Time Frame: 12 months
Systemic inflammatory burden assessed
12 months
complete hemogram indices
Time Frame: 12 months
Systemic inflammatory burden assessed
12 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Periapical index SCORE CHANGE
Time Frame: 12 months
1-5 ordinal scale,5 worse outconpme & HEALING ASSESSED
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Investigators

  • Study Director: DR SANJAY TEWARI, MDS, Post Graduate Institute Of Dental Sciences,Rohtak

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2022

Primary Completion (Actual)

February 1, 2024

Study Completion (Estimated)

April 1, 2024

Study Registration Dates

First Submitted

January 13, 2024

First Submitted That Met QC Criteria

February 13, 2024

First Posted (Estimated)

February 21, 2024

Study Record Updates

Last Update Posted (Estimated)

February 21, 2024

Last Update Submitted That Met QC Criteria

February 13, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Dr Sushma

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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