Cerebral Computed Tomography on Patients With Minor Head Injuries

Use of Cerebral Computed Tomography on Patients With Minor Head Injuries in a Danish Emergency Department: A Retrospective Cohort Study

This observational study aims to calculate the prevalence of conditions or diseases requiring immediate medical attention in CTC scans with an indication of bleeding post trauma performed in the ED at Odense University Hospital. Secondary, we aim to evaluate the Scandinavian Neurotrauma Committee clinical guideline 2013 for minor head injury.

Study Overview

• Status: Completed
• Conditions: Computed Tomography; Minor Head Injuries

Detailed Description

In this retrospective study, our primary objectives are threefold: first, to calculate the prevalence of conditions or diseases requiring immediate medical attention and to subdivide them to explore potential correlations with biochemical, clinical, and patient baseline variables using multiple regression analysis. Secondly, we wanted to analyze our use of SNC CPG and evaluate if a more stringent application could reduce the potentially unnecessary overuse of CTC. Lastly, we aim to evaluate the 30-day mortality and readmission rates to a hospital following CTC performed in the ED.

• Study Type: Observational
• Enrollment (Actual): 7106

Contacts and Locations

Study Locations

• Denmark
  • Region Syddanmark
    • Odense, Region Syddanmark, Denmark, 5000
      • Odense University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

CTCs conducted from 01.01.2023 to 31.12.2023 at Odense University Hospital (OUH) Emergency Department (ED) in Denmark.

Description

Inclusion Criteria:

• CTCs conducted from 01.01.2023 to 31.12.2023 in the ED

Exclusion Criteria:

• unrelated to trauma
• scans performed on patients under the age of 18
• CTC scans without radiologic interpretation
• Previously undergone a CTC during the same hospitalization, only the first CTC was included

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Positive CTC	Calculate the prevalence of positive CTC findings and to subdivide them to explore potential correlations with biochemical, clinical, and patient baseline variables. The CT scan was acknowledged as positive if the final radiologic interpretation of all imaging studies reported one or more listed radiological findings: Epidural hematoma; Subdural hematoma; Subarachnoid hematoma; Intraparenchymal hematoma (IPH); Intraventricular hematoma; Fossa posterior hematoma; Acute infarct or dense artery sign; Mass effect or sulcal effacement; Signs of herniation; Basal cistern compression or midline shift; Cerebral contusion; Depressed skull fracture; Diastatic skull fracture; Pneumocephalus; Cerebral edema; Diffuse axonal injury; Tumor; Intracranial infection; Other which resulted in hospitalization	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Scandinavian Neurotrauma Committee clinical practice guideline evaluation	We wanted to analyze our use of SNC CPG and evaluate if a more stringent application could reduce the potentially unnecessary overuse of CTC	1 year

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
30-day mortality and readmission rate	We aim to evaluate the 30-day mortality and readmission rates to a hospital following CTC performed in the ED.	1 year
Neurological intervention	The need for neurological intervention was defined as within 7 days requiring 1) neurosurgical intervention (e.g., craniotomy, hematoma evacuation, elevation of skull fracture, intracranial pressure monitoring, or intubation for head injuries indicated on CT) or 2) neuroradiological intervention (e.g., thrombectomy or intravascular embolization).	1 year

Collaborators and Investigators

• Sponsor: University of Southern Denmark
• Investigators: Principal Investigator: Jonas Junghans Jensen, UNIFY, University Hospital Odense, Univeristy of Southern Denmark, OPEN

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2023
• Primary Completion (Actual): December 31, 2023
• Study Completion (Actual): January 30, 2024

Study Registration Dates

• First Submitted: April 30, 2024
• First Submitted That Met QC Criteria: April 30, 2024
• First Posted (Actual): May 6, 2024

Study Record Updates

• Last Update Posted (Actual): May 6, 2024
• Last Update Submitted That Met QC Criteria: April 30, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: Emergency Department; S100B; Traumatic Brain Injuries; Scandinavian Neurotrauma Committee Guideline
• Additional Relevant MeSH Terms: Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries; Craniocerebral Trauma
• Other Study ID Numbers: UNIFY

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No