Acute Effects of Three Different Types Single Leg Exercise in Copd (COPD)

COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. One leg exercise result is not enough to highlight these parameters.

Study Overview

• Status: Completed
• Conditions: Exercise
• Intervention / Treatment: Other: single exercise bout about one-leg exercise

Detailed Description

Acute Effects of Three Different Types Single Leg Exercise in Copd

single bout high intensity interval training

single bout continuous exercise training single bout resistance training

• Study Type: Interventional
• Enrollment (Actual): 26
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Ankara
    • Ankara, Ankara, Turkey (Türkiye)
      • Elif Kocaaga

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• COPD patients that applied to physiotherapy
• cooperate to test
• no severe ortopedical and neurological disease no severe cardiovascular disease volunteer to study

Exclusion Criteria:

• have an acute exacerbation
• hypoxemia [PaO2] <55 mmHg
• no cooperated to test no volunteer to study having ortophedical and neurological diesase that affecting of tests having severe cardiovascular disease

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: single session one leg exercise intervantion in COPD; first session: single session leg Continuous exercise intervantion will be applied to COPD. Unilaterally single leg continuous exercise will be performed as only one session second session : single session leg high intensity interval exercise intervantion will be applied to COPD. Unilaterally single leg hııt exercise will be performed as only one session third sessionsingle session leg resistance exercise intervantion will be applied to COPD. Respirocally leg strength (knee extantion ) exercise will be performed

Other: single exercise bout about one-leg exercise; cycle exercise includes single leg

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
six minute walk test	six minute walk test in meter	beginning, day 1

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
cardiopulmonary exercise test	VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test	beginning, day 2
single leg extremity test	VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test	beginning, day 3
lung function	FVC in % , FEV1 in %, FEV1/FVC ratio, PEF in % and FEF 25-75 in %	beginning, day 1
muscle strength (isometric)	quadriceps isometric muscle strength will be recorded as kilogram	beginning day 1
muscle strength (10 repeated max)	quadriceps 10 repeated max muscle strength will be recorded as kilogram	beginning, day 1
continous exercise acute (single leg)	VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session	beginning day 4
high intensity interval training acute exercise (single leg)	VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session	beginning day 5
strength training acute exercise (single leg)	VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session	beginning day 4,5,6
muscle oxygenation	minumum muscle oxygenation level will be presented as percentage	beginning day 4,5,6
arterial stifness	Aıx@75 in %	beginning day 2,3, 4,5,6

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: elif kocaaga, ms, Hacettepe University

Publications and helpful links

General Publications

• Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.

Study record dates

Study Major Dates

• Study Start (Actual): February 20, 2024
• Primary Completion (Actual): March 28, 2025
• Study Completion (Actual): March 28, 2025

Study Registration Dates

• First Submitted: May 17, 2024
• First Submitted That Met QC Criteria: June 17, 2024
• First Posted (Actual): June 20, 2024

Study Record Updates

• Last Update Posted (Estimated): December 4, 2025
• Last Update Submitted That Met QC Criteria: November 26, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Behavior; Motor Activity
• Other Study ID Numbers: GO23-193

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No