An Investigation of Different Type Single Limb Exercise Training Effects in Copd (COPD)

June 18, 2024 updated by: Elif Kocaaga, Hacettepe University

An Investigation of Different Type Single Limb Exercise Training Effects on Functional Capacity, Arterial Stifness, Muscle Activation and Quality of Life in Chronic Obstructive Pulmonary Disease

COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters.

Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Three types single leg exercise intervantion will applied to COPD patients that devided three groups. One leg continuous exercise training will be aplied to one group. One leg HIIT exercise training will be aplied to other group. One leg resistance exercise training will be aplied to the last group.

Exercise capacity and muscle strength are assesed. Lung function is measured. Electormyography is recorded. Lactate and quality of life are measured.

Study Type

Interventional

Enrollment (Estimated)

66

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • COPD patients that applied to physiotherapy
  • Cooperation for tests
  • without severe ortopedical and neurological disease
  • without severe cardiovascular disease
  • To volunteer for the study.

Exclusion Criteria:

  • have an acute exacerbation or having exacerbation at last month
  • hypoxemia (PaO2<55mmHg)
  • no cooperated to test without volunteer to study having ortophedical and neurological diesase that affecting of tests severe cardiovascular disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: single leg resistance exercise intervantion in COPD
single leg resistance exercise intervantion in COPD will be perfomed at six weeks
Other: single leg exercise intervantion in COPD

single leg exercise intervantions

  1. high intensity interval training
  2. continous exercise training
  3. resistance exercise training
Other Names:
  • single leg exercise intervantion
Active Comparator: single leg continous exercise intervantion in COPD
single leg continous exercise intervantion in COPD will be perfomed at six weeks
Other: single leg exercise intervantion in COPD

single leg exercise intervantions

  1. high intensity interval training
  2. continous exercise training
  3. resistance exercise training
Other Names:
  • single leg exercise intervantion
Active Comparator: single leg high intensity exercise intervantion in COPD
single leg high intensity exercise intervantion in COPD will be perfomed at six weeks
Other: single leg exercise intervantion in COPD

single leg exercise intervantions

  1. high intensity interval training
  2. continous exercise training
  3. resistance exercise training
Other Names:
  • single leg exercise intervantion

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
six minute walk test
Time Frame: pre-intervention
six minute walk test in meter
pre-intervention

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
cardiopulmonary exercise test
Time Frame: beginning day 2
VO2 as ml/kg/min will be recorded from incremental cycle cpet test
beginning day 2
one leg cardiopulmonary exercise test
Time Frame: beginning, day 3
VO2 as ml/kg/min will be recorded from incremental cycle cpet test
beginning, day 3
quadriceps muscle strength assesing (repeated measeure)
Time Frame: beginning day 1 and last day
quadriceps muscle 10 repeated max muscle strength will be recorded at kilogram,
beginning day 1 and last day
isometrics quadriceps muscle strength assesing
Time Frame: beginning day 1 and last day
quadriceps muscle isometric muscle strength will be recorded at kilogram
beginning day 1 and last day
lung function
Time Frame: beginning day 1 and last day
FEV1/FVC ratio in %
beginning day 1 and last day
quality of life assesing
Time Frame: beginning day 1 and last day
total score in 0-100 range
beginning day 1 and last day
arterial stiffness
Time Frame: beginning day 2 and last day
total vascular resitance, augmentation index @ 75 and pulse wave velocity wil be determined arterial stiffness
beginning day 2 and last day
lactate measurement
Time Frame: beginning day 2 and last day
lactate in mmol
beginning day 2 and last day
electromyography measurement
Time Frame: beginning day 2 and last day
precentage of maximum volunteer contraction) %MVC values will be presented muscle fatigue (median frequence) and activation will be shown electromyograpy (EMG)
beginning day 2 and last day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hacettepe University

Investigators

  • Principal Investigator: elif kocaaga, ms, Hacettepe University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 16, 2023

Primary Completion (Estimated)

January 2, 2025

Study Completion (Estimated)

January 2, 2025

Study Registration Dates

First Submitted

May 17, 2024

First Submitted That Met QC Criteria

June 18, 2024

First Posted (Actual)

June 24, 2024

Study Record Updates

Last Update Posted (Actual)

June 24, 2024

Last Update Submitted That Met QC Criteria

June 18, 2024

Last Verified

June 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • KA-22104

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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