Early Neurovascular Adaptations in Aging Women

November 20, 2025 updated by: Jacqueline K Limberg, PhD, University of Missouri-Columbia
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

64

Phase

  • Early Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • United States
    • Missouri
      • Columbia, Missouri, United States, 65211
        • Recruiting
        • University of Missouri-Columbia
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Assigned female at birth (AFAB)
  • 18-70 years of age

Exclusion Criteria:

  • Assigned male at birth (AMAB)
  • Pregnancy, breastfeeding
  • Body mass index ≥30 kg/m2
  • Taking medications known to affect metabolic, autonomic, and/or respiratory function
  • Oral hormonal contraception in last 6 month
  • History of hormone replacement therapy
  • History of hyster- or oophor-ectomy
  • Current smoking/Nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Chronic disease
  • Blood pressure ≥140/90 mmHg
  • Communication barriers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Women
Women will be 18-70 years of age
Drug: Norepinephrine
Infused intra-arterially in a dose-response fashion
Drug: Isoproterenol
Infused intra-arterially in a dose-response fashion
Drug: Acetylcholine
Infused intra-arterially in a dose-response fashion
Drug: Nitroprusside
Infused intra-arterially in a dose-response fashion
Drug: Estrogen
Infused intra-arterially

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Magnitude of forearm blood flow
Time Frame: Change from baseline during infusion
Change from baseline during infusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Missouri-Columbia

Collaborators

American Heart Association (AHA)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 20, 2024

Primary Completion (Estimated)

June 30, 2027

Study Completion (Estimated)

June 30, 2028

Study Registration Dates

First Submitted

July 22, 2024

First Submitted That Met QC Criteria

July 22, 2024

First Posted (Actual)

July 25, 2024

Study Record Updates

Last Update Posted (Actual)

November 26, 2025

Last Update Submitted That Met QC Criteria

November 20, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2109189

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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