NLR and Emergency Surgery

Neutrophil-to-Lymphocyte Ratio and Mortality After Emergency Surgery

In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress. In the perioperative period, NLR has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. Since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

Study Overview

• Status: Completed
• Conditions: Emergency Surgery

Detailed Description

A retrospective analysis of patients operated on at the Clinical Hospital of the University of Chile is proposed. The search will be conducted in the electronic medical records of all patients operated on between January and December 2021, with no exclusion criteria for this analysis. Demographic data, complications, length of hospital stay, and specific characteristics such as the need for mechanical ventilation, time spent in intermediate care units, and ICU as well as total hospitalization time will be recorded. For the purpose of this study, the preoperative complete blood count of the patients will be analyzed to search for hematological variables that reflect the state of preoperative systemic inflammation.

• Study Type: Observational
• Enrollment (Actual): 851

Contacts and Locations

Study Locations

• Chile
  • Santiago, Chile, 8380456
    • Hospital Clinico de la Universidad de Chile

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Emergency patients operated on at the Clinical Hospital of the University of Chile between January and December 2021

Description

Inclusion Criteria:

• Availability of complete blood count in electronic medical records of all patients operated on between January and December 2021

Exclusion Criteria:

• None

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
NLR	Preoperative neutrophil-to-lymphocyte ratio	Day of surgery
Mortality	30 and 180 days mortality	6 months after surgery

Collaborators and Investigators

• Sponsor: University of Chile
• Investigators: Study Chair: Felipe Maldonado, M.D., M. Sc., Hospital Clinico de la Universidad de Chile

Study record dates

Study Major Dates

• Study Start (Actual): September 23, 2022
• Primary Completion (Actual): December 30, 2023
• Study Completion (Actual): December 30, 2023

Study Registration Dates

• First Submitted: August 7, 2024
• First Submitted That Met QC Criteria: August 7, 2024
• First Posted (Actual): August 12, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 11, 2024
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Keywords: Emergency surgery; Neutrophil-to-lymphocyte ratio; NLR
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Emergencies
• Other Study ID Numbers: OAIC 37/22

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No