Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments

Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments: A Clinical Study of Doctors From Peking Union Medical College Hospital

This study is a single-center prospective observational study. It plans to use a series of physiological and medical instruments and international common physiological and psychological questionnaires. To dynamically detect the changes of physiological and psychological adaptability of doctors in Peking Union Medical College Hospital before leaving Beijing, 1-7 days after arriving at the plateau in Tibet during the acute phase of plateau hypoxic stress, 2 weeks, 3 months, 6 months, 12 months after staying in Tibet during the chronic phase of plateau hypoxic stress, and after returning to Beijing.

Study Overview

• Status: Enrolling by invitation
• Conditions: High Altitude
• Intervention / Treatment: Other: measurement

• Study Type: Observational
• Enrollment (Estimated): 17

Contacts and Locations

Study Locations

• China
  • Beijing, China
    • Peking Union Medical College Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Doctors in Tibet from Peking Union Medical College Hospital

Description

Inclusion Criteria:

• Healthy individuals aged 20-65 years
• They can sign a written informed consent and is willing to cooperate
• They have the qualification to aid Tibet and meet the basic requirements of physical examination for aid to Tibet

Exclusion Criteria:

• Age less than 20 years or more than 65 years
• Unable to sign a written informed consent or unwilling to cooperate
• They do not have the qualification for supporting Tibet or do not meet the basic requirements of medical examination for supporting Tibet

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Doctors to Tibet from Peking Union Medical College Hospital in 2024	Other: measurement; Measurement of multiple physiological indicators and psychological status and multi-omics study
Doctors to Tibet from Peking Union Medical College Hospital in 2025	Other: measurement; Measurement of multiple physiological indicators and psychological status and multi-omics study

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
help understand the physiological mechanisms and psychological changes of hypoxic adaptation	This study is expected to increase our understanding of the physiological mechanisms and psychological changes of hypoxic adaptation mainly through analysis of multi-omics.	2024-5-27~2026-12-1

Collaborators and Investigators

• Sponsor: Peking Union Medical College Hospital

Study record dates

Study Major Dates

• Study Start (Actual): May 17, 2024
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2027

Study Registration Dates

• First Submitted: August 14, 2024
• First Submitted That Met QC Criteria: August 14, 2024
• First Posted (Actual): August 16, 2024

Study Record Updates

• Last Update Posted (Actual): August 16, 2024
• Last Update Submitted That Met QC Criteria: August 14, 2024
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Keywords: adaptation; high altitude; acclimatization
• Other Study ID Numbers: 2022-I2M-1-003

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No