Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization (RAPD-MR)

September 18, 2024 updated by: Zhibin Xu

Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Study Type

Observational

Enrollment (Estimated)

220000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

This study utilizes genetic data from an East Asian population, sourced from publicly available genome-wide association studies (GWAS) focused on rheumatoid arthritis and periodontitis.

Description

Inclusion Criteria:

  • Participants included in the genome-wide association study (GWAS) database.
  • Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

Exclusion Criteria:

  • Individuals without complete genotypic data or those with missing critical phenotypic information.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Causal Association Between Rheumatoid Arthritis and Periodontitis
Time Frame: Data collected from 2023 to 2024.
This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.
Data collected from 2023 to 2024.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Analysis of Genetic Pleiotropy and Confounders
Time Frame: 2023 to 2024
Evaluation of the presence of genetic pleiotropy and its potential effect on the association between rheumatoid arthritis and periodontitis.
2023 to 2024

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhibin Xu

Collaborators

Zhongshan People's Hospital, Guangdong, China

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

October 1, 2024

Primary Completion (Estimated)

November 1, 2024

Study Completion (Estimated)

December 1, 2024

Study Registration Dates

First Submitted

September 17, 2024

First Submitted That Met QC Criteria

September 17, 2024

First Posted (Actual)

September 19, 2024

Study Record Updates

Last Update Posted (Actual)

September 20, 2024

Last Update Submitted That Met QC Criteria

September 18, 2024

Last Verified

September 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KY20240918-01

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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