Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.

Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?

Participants will:

Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.

Study Overview

• Status: Recruiting
• Conditions: Health Knowledge, Attitudes, Practice
• Intervention / Treatment: Dietary supplement: CoQ10 supplementation; Dietary supplement: Placebo supplementation

• Study Type: Interventional
• Enrollment (Estimated): 24
• Phase: Phase 4

Contacts and Locations

Study Locations

• Poland
  • Gdansk, Poland, 80-333
    • Recruiting
    • Gdansk University of Physical Education and Sport
    • Contact: Zbigniew Jost, PhD; Phone Number: +48663892068; Email: zbigniew.jost@awf.gda.pl

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• training experienced for minimum 2 years
• running training at least 2 times per week
• Personal Best on 10k (<50 minutes)

Exclusion Criteria:

• taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
• injured in last 6 months to avoid n number reduction

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CoQ10-treated participants; The participants will be treated with CoQ10 supplements	Dietary supplement: CoQ10 supplementation; Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.
Placebo Comparator: Placebo-treated participants; The participants will be treated with placebo	Dietary supplement: Placebo supplementation; Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.	The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.	The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.	The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.	The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill	The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer	The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Collaborators and Investigators

• Sponsor: Gdansk University of Physical Education and Sport

Study record dates

Study Major Dates

• Study Start (Actual): August 23, 2024
• Primary Completion (Actual): July 21, 2025
• Study Completion (Estimated): July 30, 2026

Study Registration Dates

• First Submitted: August 6, 2024
• First Submitted That Met QC Criteria: September 25, 2024
• First Posted (Actual): October 1, 2024

Study Record Updates

• Last Update Posted (Estimated): August 26, 2025
• Last Update Submitted That Met QC Criteria: August 19, 2025
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Keywords: Supplementation; Cognition; Coenzyme Q10; Myokine; Exerkine; Long-distance runners
• Additional Relevant MeSH Terms: Behavior; Physiological Effects of Drugs; Micronutrients; Vitamins; Coenzyme Q10
• Other Study ID Numbers: AWFiS/2024_3_ZJ

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No