Post Bariatric Surgery Acute Kidney Injury: Incidence and Risk Factors

November 17, 2024 updated by: Georgina Tharwat Abdelmasih

Bariatric surgery is the most effective means of inducing and maintaining sustained weight loss. Apart from the weight loss effect, bariatric surgery leads to the remission of chronic metabolic disorders such as type 2 diabetes (T2D) and hypertension . Recent studies have shown that bariatric surgery improves renal perfusion and glomerular function and reduces inflammatory markers which can lead to an improvement of microalbuminuria and proteinuria However, acute kidney injury (AKI) can complicate the postoperative course after bariatric surgery. The etiology of AKI after bariatric surgery can be multifactorial and complex in obese population . The preexisting factors such as diabetes, hypertension, and CKD in these patients can additionally worsen the renal insult during the postoperative period . Postoperative AKI is associated with increase morbidity and mortality especially in cases of severe AKI that requires dialysis support . Identifying the high-risk patients for development of postoperative AKI would prevent renal injury. Our aim was to study the incidence and etiology of postoperative AKI after bariatric surgery . Causes of post bariatric surgery AKI include . Pre renal causes :dehydration ( repeated vomiting and diarrhoea)which are common complications post bariatric surgery , haemorrhagic shock (from the site of anastomosis , ulcer ) , septic shock ( leakage , pneumonia) , hypotension and respiratory depression secondary to narcotic overdose. Rena causes: contract induced nephropathy after using CT scan guided drainage of intra abdominal collection post operative, Rhabdomylosis , drug induced nephropathy e.g :using of IV vancomycin for sepsis in ICU .. many causes can lead to AkI post bariatric surgery but the common two causes are dehydration and sepsis .

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Georgina Tharwat Abdelmasih, Master
Phone Number: +20 1203254445 georginatharwat8@gmail.com
Email: georginatharwat8@gmail.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Sampling Method

Probability Sample

Study Population

multi central study in Egypt

Description

Inclusion criteria:
1. Age more than 18 years old undergo bariatric surgery .
2. BMI ≥30 : ( BMI = weight in kg / height in m²)
Exclusion criteria:
1. previous kidney diseases(AKI , CKD) .
2. patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
Patient undergo bariatric surgery Inclusion criteria: Age more than 18 years old undergo bariatric surgery . BMI ≥30 : ( BMI = weight in kg / height in m²) Exclusion criteria: previous kidney diseases(AKI , CKD) . patients unfit for surgery e.g ( comorbidities : CHD , LCF ) 3. Drugs : (ACE-I , ARBs, and NSAIDS)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
incidence Time Frame: Baseline	assess the incidence of postoperative AKI after bariatric surgery .	Baseline
Risk factors Time Frame: Baseline	assess the risk factors of postoperative AKI after bariatric surgery	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
duration of hospitalization Time Frame: Baseline	Assess the duration of hospitalization, and it's relation with the incidence of AKI	Baseline
readmission Time Frame: Baseline	Assess the duration of readmission within 30 d after surgery and it's relation with the incidence of AKI	Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Georgina Tharwat Abdelmasih

Collaborators

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2024

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

February 1, 2027

Study Registration Dates

First Submitted

November 14, 2024

First Submitted That Met QC Criteria

November 17, 2024

First Posted (Estimated)

November 20, 2024

Study Record Updates

Last Update Posted (Estimated)