CRP /albumin Ratio and Neutrophil Lymphocyte Ratio in Predicting Activity in IBD Patients

CRP/ Albumin Ratio and Neutrophil Lymphocyte Ratio in Predicting Activity in IBD Patients

This study aimed to assess the clinical utility of the NLR (neutrophil lymphocyte ratio) and CRP Albumin ratio in predicting activity of IBD Patients in assiut university

Study Overview

• Status: Not yet recruiting
• Conditions: Inflammatory Bowel Disease (IBD)

Detailed Description

IBD definition term for two conditions (Crohn's disease and ulcerative colitis) is a chronic idiopathic inflammatory disease affecting the large intestine. It is characterized by relapsing mucosal inflammation. The aim of treatment is to induce and maintain disease remission. Assessing disease activity may help in optimizing the management of IBD patients.

The neutrophil-to-lymphocyte ratio (NLR) is a simple index that can be calculated from the results of ordinary blood tests; it is calculated from a blood sample by dividing the absolute neutrophil count by the absolute lymphocyte count . As the NLR can reflect the systemic status of inflammation or immune response.

The underlying mechanism that the NLR was a predictor of clinilcal relapse in UC patients with Mucosal healing remains poorly understood. Neutrophils induce cytotoxicity and inflammation in UC. A high NLR value may be due to high activity in UC and lowered mucosal barrier function, which may lead to the migration of neutrophils through the gut microbiota .

CRP is routinely used as a surrogate measure of intestinal inflammation and as a prognostic measure of nonresponse to medical therapy and colectomy in patients with IBD.

• Study Type: Observational
• Enrollment (Estimated): 35

Contacts and Locations

• Study Contact: Name: Amira Mohamed Ali Ahmed; Phone Number: 01090176978; Email: am3859282@gmail.com

Study Locations

• Egypt
  • Assiut, Egypt
    • Assiut university
    • Contact: Assiut university hospital Albumin Creatinine ratio and N/L ratio in active IBD patients; Phone Number: +2001090176978; Email: Amira.16266428@med.aun.edu.eg
  • Egypt, Assiut, Egypt
    • Assiut University hospital
    • Contact: Assiut university hospital Albumin Creatinine ratio and N/L ratio in active IBD patients; Phone Number: +2001090176978; Email: Amira.16266428@med.aun.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Pt more than 18 years not DM not cardiac failure Not Liver failure No malignancy

Description

Inclusion Criteria:

Patients more than 18 years newly diagnosed as IBD

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Exclusion Criteria:

• Patients Not DM Not cardiac failure Not Liver failure No malignancy

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
C-reactive protein /albumin ratio and neutrophil lymphocyte ratio in predicting activity in Inflammatory Bowel Disease Patients	Neutrophil lymphocyte ratio and CRP/Albumin ratio in detecting activity in IBD Patients.	1 years

Collaborators and Investigators

• Sponsor: Assiut University

Publications and helpful links

General Publications

• Torun S, Tunc BD, Suvak B, Yildiz H, Tas A, Sayilir A, Ozderin YO, Beyazit Y, Kayacetin E. Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity. Clin Res Hepatol Gastroenterol. 2012 Oct;36(5):491-7. doi: 10.1016/j.clinre.2012.06.004. Epub 2012 Jul 27.
• Nguyen AL, Brick C, Liu D, Gibson DJ, Gibson PR, Sparrow MP. Clinical utility of C-reactive protein-to-albumin ratio in the management of patients with inflammatory bowel disease. JGH Open. 2024 Apr 15;8(4):e13059. doi: 10.1002/jgh3.13059. eCollection 2024 Apr.
• Demir AK, Demirtas A, Kaya SU, Tastan I, Butun I, Sagcan M, Sahin S, Tasliyurt T, Yilmaz A. The relationship between the neutrophil-lymphocyte ratio and disease activity in patients with ulcerative colitis. Kaohsiung J Med Sci. 2015 Nov;31(11):585-90. doi: 10.1016/j.kjms.2015.10.001. Epub 2015 Oct 31.
• Langley BO, Guedry SE, Goldenberg JZ, Hanes DA, Beardsley JA, Ryan JJ. Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review. J Clin Med. 2021 Sep 17;10(18):4219. doi: 10.3390/jcm10184219.

Study record dates

Study Major Dates

• Study Start (Estimated): January 1, 2025
• Primary Completion (Estimated): October 1, 2025
• Study Completion (Estimated): December 1, 2025

Study Registration Dates

• First Submitted: September 20, 2024
• First Submitted That Met QC Criteria: December 24, 2024
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 24, 2024
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Keywords: CRP/ALB ratio; N/L ratio
• Additional Relevant MeSH Terms: Intestinal Diseases; Digestive System Diseases; Gastrointestinal Diseases; Gastroenteritis; Inflammatory Bowel Diseases
• Other Study ID Numbers: CRP/ALB and N/L In active IBD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No