The Influence of Talocrural Manipulation on Proprioception in Stroke

May 23, 2026 updated by: Omer Dursun, Bitlis Eren University

The Effect of Talocrural Joint Manipulation on Ankle Proprioception in Post-Stroke Patients

The aim of the study is to investigate the effect of talocrural joint manipulation on the ankle proprioception of patients with stroke.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

The study, utilizing a randomized crossover design, is planned to be conducted on a minimum of 26 patients with stroke who meet the inclusion and exclusion criteria. Patients included in the study will be randomly assigned to receive both placebo talocrural joint manipulation and talocrural joint manipulation interventions.

Study Type

Interventional

Enrollment (Estimated)

26

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Turkey (Türkiye)
    • Merkez
      • Bolu, Merkez, Turkey (Türkiye), 14280
        • Recruiting
        • Bolu İzzet Baysal Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
        • Contact:
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. Two months or longer elapsed since the stroke,
  2. A Mini-Mental State Examination score of 24 or higher,
  3. Being between 45 and 75 years of age,
  4. Having a Brunnstrom stage of 4 or above

Exclusion Criteria:

  1. The presence of severe osteoarthritis in the lower extremity,
  2. The presence of cancer or diabetic neuropathy,
  3. The presence of vestibular disorder,
  4. The presence of lower extremity ulceration or amputation,
  5. Hemodynamic instability,
  6. The presence of other neurological disorders (such as multiple sclerosis, Parkinson's disease),
  7. Having experienced an acute lower extremity injury in the last six weeks,
  8. History of lower extremity surgery
  9. Lack of available range of motion values required for the ankle proprioception test

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Placebo Talocrural Joint Manipulation Group
In this group, patients will receive placebo talocrural joint manipulation. The application will be similar to that in the experimental group, however, hands will be positioned to avoid creating traction or manipulation force, and this position will be maintained for 20 seconds.
Other: Placebo Talocrural Joint Manipulation
This intervention is a classic method used to evaluate the effect of talocrural joint manipulation.
Experimental: Talocrural Joint Manipulation Group
In this group, talocrural joint manipulation will be applied. After positioning the patient, high velocity low amplitude traction will be applied.
Other: Talocrural Joint Manipulation
This technique, aiming to increase ankle dorsiflexion and mechanoreceptor activation, is based on the application of high velocity low amplitude traction to the joint.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Ankle Proprioception
Time Frame: Change from baseline ankle proprioception immediately after the intervention
The effect of talocrural joint manipulation on ankle proprioception will be evaluated using the Cybex isokinetic dynamometer. The device will analyze the passive joint position sense of the ankle in various positions.
Change from baseline ankle proprioception immediately after the intervention

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Ankle Dorsiflexion Measurement
Time Frame: Change from baseline ankle dorsiflexion immediately after the intervention
For the measurement of dorsiflexion range of motion, patients will be asked to stand facing a wall with the assessed leg positioned at the back. They will place their hands on the wall at shoulder width. While keeping the back knee in at least 20 degrees of flexion and ensuring the foot remains in contact with the ground, they will be instructed to lean forward as far as possible. The dorsiflexion range of motion will then be measured using a spirit level application on an iPhone placed one centimeter above the calcaneal tuberosity.
Change from baseline ankle dorsiflexion immediately after the intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bitlis Eren University

Investigators

  • Principal Investigator: ömer dursun, Asst. Prof., Bitlis Eren University
  • Principal Investigator: Burak Mavuş, M.Sc., Bolu Abant İzzet Baysal Physiotherapy and Rehabilitation Training and Research Hospital
  • Principal Investigator: Merve Tunçdemir, Asst. Prof., Bitlis Eren University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 14, 2025

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

July 1, 2026

Study Registration Dates

First Submitted

February 22, 2025

First Submitted That Met QC Criteria

February 22, 2025

First Posted (Actual)

February 27, 2025

Study Record Updates

Last Update Posted (Actual)

May 27, 2026

Last Update Submitted That Met QC Criteria

May 23, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • BEUFTR-6

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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