Efficacy and Safety of Biweekly Regimen of Eribulin Versus a Standard Regimen for the Treatment of Locally Recurrent or Metastatic HER2-negative Breast Cancer: a Multicenter, Randomized, Open-label, Phase III Trial

Eribulin is a soft spongin-like inhibitor of mitotic microtubule dynamics in cells. From the evidence of efficacy, the STUDY 305 and STUDY 301 studies suggest that eribulin improves PFS and OS in patients with breast cancer. Eribulin has a good safety profile with a low incidence of patient-perceivable adverse effects, with myelosuppression being the main adverse effect, and neutropenia, anemia, and also fatigue being the most common adverse effects. However, serious neutropenia, may result in delayed dosing, dose reduction or discontinuation in some patients.

In studies of standard regimen therapy with eribulin, grade 3-4 neutropenia occurred in approximately 45% of patients, of which approximately 25% required dose adjustment or discontinuation of therapy, which has become an urgent clinical problem in the treatment of eribulin. Therefore, a modified bi-weekly regimen of eribulin (1.4 mg/m2 intravenously on days 1 and 15 of a 28-day cycle), based on the standard regimen (1.4 mg/m2 intravenously on days 1 and 8 of a 21-day cycle), is expected to improve the safety of eribulin administration without compromising efficacy, in order to minimize dose reductions of the medication and interruptions of therapy, thereby improving patients' quality of life.

There is still a lack of head-to-head studies on the efficacy and safety of the combination of eribulin standard regimen and biweekly regimen in HER2-negative advanced breast cancer, and the treatment data in the Chinese population need to be further explored. The aim of this study is to explore the efficacy and safety of eribulin biweekly regimen compared with the standard regimen in patients with locally recurrent or metastatic HER2-negative breast cancer, and to provide a clinical evidence-based basis for the optimization of eribulin treatment regimen.

Study Overview

• Status: Enrolling by invitation
• Conditions: Breast Cancer Metastatic
• Intervention / Treatment: Drug: Eribulin biweekly regimen; Drug: Eribulin standard regimen

• Study Type: Interventional
• Enrollment (Estimated): 192
• Phase: Phase 3

Contacts and Locations

Study Locations

• China
  • B
    • Beijing, B, China, 100020
      • Cancer Hospital Chinses Academy of Medical Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Over 18 years old
2. ECOG 0-2
3. Expected survival of not less than 12 weeks
4. At least one measurable lesion
5. With HER2 negative locally recurrent or metastatic breast cancer
6. Metastatic breast cancer advanced stage received ≤3 lines of chemotherapy
7. Previous anthracycline and paclitaxel therapy

8. Well organ functional status 1）routine blood test

   • ANC≥1.5×109/L；
   • PLT≥90×109/L；
   • Hb≥90 g/L； 2）blood biochemistry
   • TBIL≤1.5×ULN；
   • ALT/AST≤2×ULN；patients with liver matastasis ALT/AST≤5×ULN；
   • BUN/Cr≤1.5×ULN and creatinine clearance ≥50 mL/min （Cockcroft-Gault） 3）cardiology ultrasound
   • LVEF≥50%；
9. Signed informed consent, good compliance and willingness to cooperate with follow-up visits

Exclusion Criteria:

1. With third interstitial fluid that cannot be controlled by drainage or other means
2. Symptomatic brain or meningeal metastases
3. Patients with only bone or skin as the sole target lesion
4. Pre-existing other malignant tumors
5. Patients who have used eribulin in the adjuvant and palliative phases of care
6. Known history of allergy to components of this regimen; history of immunodeficiency
7. Pregnant or breastfeeding female patients, female patients of childbearing potential with a positive baseline pregnancy test or female patients of childbearing potential who are unwilling to use effective contraception throughout the trial period
8. Have a concomitant illness that, in the investigator's judgment, seriously jeopardizes the patient's safety, or interferes with the patient's ability to complete the study.
9. A clear past history of neurological or psychiatric disorders
10. Any other condition for which the investigator believes the patient is not suitable to participate in this study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: eribulin biweekly regimen	Drug: Eribulin biweekly regimen; Eribulin biweekly regimen
Experimental: eribulin standard regimen	Drug: Eribulin standard regimen; Eribulin standard regimen

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical benefit rate	Clinical benefit was defined as patients who achieve complete response/partial response or stable disease of over 6 months	From enrollment to the end of treatment at 8 weeks

Collaborators and Investigators

• Sponsor: Ma Fei，MD
• Investigators: Study Chair: Hongnan Mo, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Study record dates

Study Major Dates

• Study Start (Actual): July 13, 2023
• Primary Completion (Estimated): July 13, 2026
• Study Completion (Estimated): July 13, 2026

Study Registration Dates

• First Submitted: February 26, 2025
• First Submitted That Met QC Criteria: February 26, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 26, 2025
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Site; Neoplasms; Skin Diseases; Breast Diseases; Breast Neoplasms
• Other Study ID Numbers: NCC4143

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No