Unique Electroencephalography (EEG) Markers of Habit Behaviors in Obsessive-Compulsive Disorder (OCD)

May 27, 2025 updated by: Shanghai Mental Health Center

Using Forced-response Model and Drift-diffusion Model to Explore OCD's Unique Electroencephalographic Markers of Habit Formation and Expression

This study focuses on explaining the occurrence and development of compulsive behaviors from habit hypothesis. Investigators will study both OCD patients and healthy individuals using Hardwick's forced-response time task(2019), the habit Go/No-Go task, and the Intra-Extra Dimensional Set Shift task. Investigators aim to explore the cognitive abilities and differences between OCD patients and healthy controls in these three tasks. Control variables will include participants' levels of anxiety, depression, and stress, as well as sense of incompleteness and intolerance of uncertainty levels. By examining the differences in habit formation and expression abilities between OCD patients and healthy controls, and exploring the specific brain electroencephalographic activity processes in OCD patients, investigators hope to reveal the abnormal neural activity in habit-related circuits in OCD patients. This could provide new insights for the diagnosis and treatment of OCD.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

35

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Shanghai
      • Shanghai, Shanghai, China, 200030
        • Shanghai Mental Health Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Aged between 18 and 50;
  2. Y-BOCS score greater than or equal to 16;
  3. Meet DSM-5 diagnostic criteria with no medication changes in the past two weeks;
  4. Right-handed.

Exclusion Criteria:

  1. Diagnosed with any DSM-5 disorder other than OCD;
  2. Have a major physical illness;
  3. Have strong suicidal ideation.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Habit formation
Behavioral: habit formation training
Participants need to perform habit formation exercises for 4 consecutive days. During the exercises, participants will see a picture stimulus and need to learn the corresponding key press. Each day, participants will spend 30 minutes on the training.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Reduction of Y-BOCS scores
Time Frame: baseline#after- intervention#1 weeks# (pre-intervention, after intervention, one weeks after intervention)
We defined the habit training response as the percent reduction of Y-BOCS scores greater than or equal to 35%.
baseline#after- intervention#1 weeks# (pre-intervention, after intervention, one weeks after intervention)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shanghai Mental Health Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 5, 2024

Primary Completion (Actual)

April 30, 2025

Study Completion (Estimated)

July 30, 2025

Study Registration Dates

First Submitted

May 29, 2024

First Submitted That Met QC Criteria

March 18, 2025

First Posted (Actual)

March 19, 2025

Study Record Updates

Last Update Posted (Actual)

May 28, 2025

Last Update Submitted That Met QC Criteria

May 27, 2025

Last Verified

April 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SMHC-OCD-010

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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