Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a CBCT Study

April 29, 2026 updated by: VANDE VANNET Bart, Central Hospital, Nancy, France

Correlation Between the Midpalatal Suture Maturity and the Maxillary Third Molar Mineralization: a Cone Beam Computed Tomography Study

Assessing the maturation of the mid-palatal suture is an essential criterion for orthodontic decision-making. However, from a CBCT according to Angelieri's classification , it remains difficult for the practitioner's untrained eye.

As profile teleradiographs are almost routinely performed in orthodontic check-ups, numerous studies have looked for a correlation between the stage of maturation of the palatal suture and that of the cervical vertebrae. Some have also looked for a link with mineralization of mandibular third or second molars according to Demirjian's classification.

These techniques would provide a reliable and reproducible method without the use of CBCT.

In our study, the investigators will be looking for a correlation with mineralization of the maxillary third molar according to Nolla's classification. The latter has become common in practice and easy to apply on an orthopantomogram.

This would simplify decision-making without the need for a CBCT, but by using the orthopantomogram which is already routinely performed during the assessment.

Study Overview

Status

Completed

Conditions

Detailed Description

The study is a non-interventional (observational) research involving the human person, research on existing data (retrospective study).

This study analyzes the maturation stage of the Midpalatal suture and the mineralization of the third left molar.

This is a comparative retrospective study of radiographs in three dimensions before any orthodontic treatment to study a potential correlation.

There is no control group but there are subgroups depending of the age of the patients.

Study Type

Observational

Enrollment (Actual)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
    • France
      • Nancy, France, France, 54000
        • Caroline Bertazzon

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Odontology department's patients

Description

Inclusion Criteria:

  • No previous orthodontic or orthopedic treatment
  • At least the maxillary third left molar
  • No skeletal disability

Exclusion Criteria:

  • Previous maxillofacial trauma
  • Dentofacial deformities
  • Endocrinological pathologies with implications for maxillofacial growth • - Syndromes
  • History of maxillofacial or orthognathic surgery
  • History of orthodontic treatment
  • Incomplete data or incomplete CBCT
  • Maxillary third left molar fracture/cavity/other deterioratedation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Patient aged under 14 years
Patients aged under 14 years.
Patients aged between 14 and 18 years.
Patients aged between 19 and 25 years.
Patients aged over 25 years.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Maturation stages of the midpalatal suture
Time Frame: One day
Stages according to Angelieri et al.
One day
Third molar calcification
Time Frame: One day
Calcification's stages of the third left molar maxillary (from 0 to 10) according to Nolla.
One day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Central Hospital, Nancy, France

Investigators

  • Study Director: Bart VANDE VANNET, PhD, Central Hospital, Nancy, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2026

Primary Completion (Actual)

March 26, 2026

Study Completion (Actual)

March 26, 2026

Study Registration Dates

First Submitted

September 12, 2025

First Submitted That Met QC Criteria

September 17, 2025

First Posted (Actual)

September 18, 2025

Study Record Updates

Last Update Posted (Actual)

April 30, 2026

Last Update Submitted That Met QC Criteria

April 29, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2025PI009

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Maturation of the Midpalatal Suture and Maxillary Third Molar Mineralization in Healthy Individuals

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Congo

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe