Progression Patterns of Choroidal Venous Alterations (CVA)

International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

Study Overview

• Status: Recruiting
• Conditions: Pachychoroid Disease

Detailed Description

This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.

• Study Type: Observational
• Enrollment (Estimated): 250

Contacts and Locations

• Study Contact: Name: Gemmy Cheung; Phone Number: +65 63227460; Email: gemmy.cheung.c.m@singhealth.com.sg

Study Locations

• Hong Kong
  • Hong Kong, Hong Kong
    • Not yet recruiting
    • Hong Kong University
    • Contact: Angie Fong; Phone Number: 852 2518 1430; Email: fongahc@hku.hk
• Malaysia
  • Kuala Lumpur, Malaysia
    • Recruiting
    • University of Malaya Medical Centre
    • Contact: Lott Pooi Wah Dr; Phone Number: 03-79677022; Email: lottpw@um.edu.my
• Singapore
  • Singapore, Singapore
    • Not yet recruiting
    • National University Hospital, Singapore
    • Contact: Wendy Wong; Phone Number: +65; Email: wendy_wong@nuhs.edu.sg
  • Singapore, Singapore
    • Recruiting
    • Singapore National Eye Centre/ Singapore Eye Research Institute
    • Contact: Gemmy Cheung; Phone Number: +65 63227460; Email: gemmy.cheung.c.m@singhealth.com.sg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya

Description

Inclusion Criteria:

1. Adults aged 45 years or older.
2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes
4. Willing to provide written informed consent

Exclusion Criteria:

1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
4. Pregnant or nursing women
5. Persons who are unable to give informed consent

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Progression of choroidal venous alterations	Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.	3 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of progression of pachychoroid disease manifestation	New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.	3 years
Risk factors associated with progression of choroidal venous alteration	Assessment of demographic, cilinical, and imaging parameters associated with progression.	3 years

Collaborators and Investigators

• Sponsor: Singapore National Eye Centre
• Collaborators: National University Hospital, Singapore; University of Malaya; Hong Kong University

Study record dates

Study Major Dates

• Study Start (Actual): March 4, 2025
• Primary Completion (Estimated): June 1, 2029
• Study Completion (Estimated): August 1, 2029

Study Registration Dates

• First Submitted: November 14, 2025
• First Submitted That Met QC Criteria: November 14, 2025
• First Posted (Estimated): November 19, 2025

Study Record Updates

• Last Update Posted (Actual): November 28, 2025
• Last Update Submitted That Met QC Criteria: November 21, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 2024-4359

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No