Incidental Findings on Coronary Computed Tomography Angiography

December 22, 2025 updated by: Jordan Collaborating Cardiology Group

Incidental Noncardiac Findings on Coronary Computed Tomography Angiography

Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

The increasing utilization of coronary computed tomography (CT) angiography (CCTA) to diagnose and triage patients with suspected or known ischemic heart disease has led to a parallel increase in the frequency of incidental findings in the coronaries (nonatherosclerotic), noncoronary cardiac structures and noncardiac structures.

Studies have reported a prevalence of incidental findings on CCTA up to 40%. Most of these findings have no clinical relevance, but some have significant clinical implications in the care and prognosis of the patients.

We sought to assess the frequency of incidental findings on CCTA scans in consecutive studies performed in the past 5 years.

Study Type

Observational

Enrollment (Estimated)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Musa Saadeh
  • Phone Number: 065001000

Study Locations

  • Jordan
      • Amman, Jordan, 11184
        • Istishari Hospital
        • Contact:
        • Contact:
          • Wasfi Alghween, MD
          • Phone Number: 065001000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

  1. All adult patients who underwent CCTA for chest pain diagnosis.
  2. Scans will be reviewed seeking the presence of coronary non atherosclerotic disease in the coronaries, cardiac structure and non cardiac structures.

Description

Inclusion Criteria:

  • Adult patients ho underwent CCTA

Exclusion Criteria:

  • None

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Adult patients who underwent CCTA
All adults (18 years of age and older0 who underwent CCTA to evaluate the coronary arteries in the past 5 years will have their CT scans reviewed for the presence of non coronary incidental findings.
Diagnostic test: CCTA (Review of the scans)
Reviewing coronary scans done in the past 5 years looking for findings other than atherosclerotic coronary artery disease.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Non atherosclerotic coronary disease
Time Frame: BASELINE
Findings other than coronary atherosclerotic disease: coronary bridge, coronary dissection, coronary embolism, and coronary fistula.
BASELINE
Non coronary cardiac findings
Time Frame: BASELINE
Findings include valve calcifications, left atrial appendage thrombus, patent foramen ovale and septal defects, pericardial effusion, LV clots, cardiac tumors.
BASELINE
Non cardiac findings
Time Frame: BASELINE
Non cardiac findings include: a. major vascular abnormalities in the aorta and the pulmonary arteries, b. pulmonary disease: masses, lymph nodes, granulomas, and pleural effusion, and c. non pulmonary findings in the diaphragm and the hepatobiliary tree.
BASELINE

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jordan Collaborating Cardiology Group

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 2, 2026

Primary Completion (Estimated)

January 2, 2027

Study Completion (Estimated)

February 28, 2027

Study Registration Dates

First Submitted

November 28, 2025

First Submitted That Met QC Criteria

November 28, 2025

First Posted (Estimated)

December 10, 2025

Study Record Updates

Last Update Posted (Actual)

December 30, 2025

Last Update Submitted That Met QC Criteria

December 22, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • JOINCIDENT.CCTA.NOV2025/3

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

The excel sheet of the incidental findings in the 2000 CCTA scans in possession of the investigators will be available to any physician upon request

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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