Double Triggering Asynchrony in Mechanically Ventilated Patients.

Sensitivity of Diaphragmatic Ultrasonography in Detecting Double Triggering Asynchrony in Mechanically Ventilated ICU Patients.

This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem affects critically ill patients. Findings may help improve ventilator care in intensive care units.

Study Overview

• Status: Completed
• Conditions: Critical Illness; Respiratory Failure; Mechanical Ventilation

• Study Type: Observational
• Enrollment (Actual): 28

Contacts and Locations

Study Locations

• Egypt
  • Dakahlia Governorate
    • Al Mansurah, Dakahlia Governorate, Egypt, 35516
      • Specialised Medical Hospital - ICU

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Adult patients (>18 years) admitted to medical/surgical ICU at Specialized Medical Hospital, Mansoura University, receiving invasive mechanical ventilation with documented double triggering asynchrony on ventilator waveform analysis.

Description

Inclusion Criteria:

• Adult ICU patients aged ≥18 years receiving invasive mechanical ventilation
• Documented double triggering asynchrony on ventilator waveform analysis.

Exclusion Criteria:

• Patients with contraindications to diaphragmatic ultrasound, including thoracic or abdominal surgery.
• Patients with known diseases affecting diaphragmatic function, such as Duchenne muscular dystrophy (DMD) or myasthenia gravis (MG).
• Patients with advanced chronic liver disease (Child-Pugh class C)
• Patients with chronic increased intra-abdominal pressure.
• Patients with moderate to massive pleural effusion.
• Patient or legal guardian refusal to participate in the study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Double Triggering Cohort; 28mechanically ventilated ICU patients identified with double triggering asynchrony

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Sensitivity of diaphragmatic ultrasound for detection of double triggering asynchrony	Proportion of double triggering asynchrony events correctly identified by diaphragmatic ultrasound compared with ventilator waveform analysis as the reference standard	During ICU admission, at the time of double triggering detection by ventilator graph interpretation

Collaborators and Investigators

• Sponsor: Mansoura University

Study record dates

Study Major Dates

• Study Start (Actual): November 5, 2024
• Primary Completion (Actual): October 20, 2025
• Study Completion (Actual): November 2, 2025

Study Registration Dates

• First Submitted: January 17, 2026
• First Submitted That Met QC Criteria: January 24, 2026
• First Posted (Actual): February 2, 2026

Study Record Updates

• Last Update Posted (Actual): April 15, 2026
• Last Update Submitted That Met QC Criteria: April 10, 2026
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Mechanical Ventilation; Diaphragmatic Ultrasound; Double Triggering; Patient-Ventilator Asynchrony
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Respiratory Tract Diseases; Respiration Disorders; Signs and Symptoms, Respiratory; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Patient-Ventilator Asynchrony; Respiratory Insufficiency; Critical Illness
• Other Study ID Numbers: MD.24.03.838.R1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No