Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation (OLV-INDICES)

January 25, 2026 updated by: Onur KARSLIOĞLU, Ankara Ataturk Sanatorium Training and Research Hospital

Correlation Between Oxygenation Indices (OI and Their Derivatives) and Oxygen Saturation Indices (OSI and Their Derivatives) During One-Lung Ventilation in Thoracic Surgery

One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics. Traditional oxygenation indices require arterial blood gas analysis and do not fully reflect the mechanical stress applied to the lungs.

This prospective observational study aims to evaluate the correlation between oxygenation indices and oxygen saturation indices during one-lung ventilation in adult patients undergoing elective thoracic surgery. Modified indices incorporating driving pressure and mechanical power will also be assessed.

No intervention beyond standard clinical care will be applied. The findings of this study may help clarify the clinical utility of non-invasive oxygenation indices for intraoperative monitoring during one-lung ventilation.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

One-lung ventilation induces complex changes in pulmonary physiology, including increased intrapulmonary shunt and altered respiratory mechanics, which may challenge conventional approaches to intraoperative oxygenation assessment. While invasive oxygenation indices are widely used, their applicability during one-lung ventilation is limited by the need for arterial blood gas sampling and the lack of integration of mechanical ventilation-related stress.

Non-invasive oxygen saturation-based indices have been proposed as alternatives; however, data regarding their performance under the dynamic physiological conditions of one-lung ventilation remain scarce. Furthermore, emerging concepts in lung-protective ventilation emphasize the importance of driving pressure and mechanical power as determinants of ventilator-induced lung injury, yet these parameters are not incorporated into traditional oxygenation metrics.

In this prospective observational study, invasive and non-invasive oxygenation indices, including modified forms incorporating driving pressure and mechanical power, will be recorded simultaneously during one-lung ventilation in adult patients undergoing elective thoracic surgery. The relationships and agreement between these indices will be analyzed to assess their comparability across different levels of mechanical respiratory load.

No intervention beyond standard clinical care will be applied. Ventilatory settings and perioperative management will be determined solely by routine clinical practice. This study is designed to provide methodological insight into the intraoperative applicability of non-invasive oxygenation indices during one-lung ventilation.

Study Type

Observational

Enrollment (Estimated)

51

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients aged 18 years and older with ASA physical status I-III who are scheduled for elective thoracic surgery requiring intraoperative one-lung ventilation for at least one hour. All participants undergo standard perioperative management with simultaneous arterial blood gas analysis and continuous pulse oximetry monitoring during surgery.

Description

Inclusion Criteria:

  • Patients aged 18 years and older
  • Patients classified as ASA physical status I-III
  • Patients scheduled for elective thoracic surgery requiring one-lung ventilation for at least 1 hour intraoperatively
  • Patients in whom simultaneous arterial blood gas analysis and continuous SpO₂ monitoring can be performed
  • Patients who have provided written informed consent

Exclusion Criteria:

  • Patients undergoing emergency surgery
  • Patients younger than 18 years of age
  • Patients classified as ASA physical status IV or higher
  • Patients with a history of previous thoracic surgery
  • Patients with a body mass index (BMI) >40 kg/m² or <18 kg/m²
  • Patients with advanced chronic lung disease (COPD stage III-IV)
  • Patients with New York Heart Association (NYHA) class III-IV heart failure
  • Patients undergoing surgery due to pleural effusion

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
One-Lung Ventilation Cohort
Adult patients undergoing elective thoracic surgery requiring one-lung ventilation. All patients will be managed according to standard clinical practice. No intervention is assigned as part of this observational study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Correlation between oxygenation indices and oxygen saturation indices
Time Frame: During intraoperative one-lung ventilation
Correlation between invasive oxygenation indices (oxygenation index and its derivatives) and non-invasive oxygen saturation indices (oxygen saturation index and its derivatives) measured during one-lung ventilation.
During intraoperative one-lung ventilation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara Ataturk Sanatorium Training and Research Hospital

Investigators

  • Principal Investigator: Onur KARSLIOĞLU, ANKARA ATATURK SANATORİUM TRAİNİNG AND RESEARCH HOSPITAL

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 9, 2026

Primary Completion (Estimated)

June 9, 2026

Study Completion (Estimated)

August 9, 2026

Study Registration Dates

First Submitted

January 25, 2026

First Submitted That Met QC Criteria

January 25, 2026

First Posted (Actual)

February 2, 2026

Study Record Updates

Last Update Posted (Actual)

February 2, 2026

Last Update Submitted That Met QC Criteria

January 25, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • OLV-OXY-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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