Prediction of Outcome to Neoadjuvant Therapy in Non-small Cell Lung Cancer（NSCLC）

March 18, 2026 updated by: Qian Chu

A Study on Multimodal Data Prediction of Outcome to Neoadjuvant Therapy in NSCLC

This observational study aims to construct and validate the performance of a multimodal predictive model in forecasting the outcomes of neoadjuvant therapy in patients with NSCLC.

The core research question is: Can a multi-model approach predict outcomes of neoadjuvant therapy for non-small cell lung cancer and provide clinical recommendations?

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Hubei
      • Wuhan, Hubei, China, 430030
        • Recruiting
        • Tongji Hospital
        • Contact:
          • Minghao Hu
          • Phone Number: 8613396366466
    • Zhejiang
      • Hangzhou, Zhejiang, China, 430030
        • Recruiting
        • Sir Run Run Shaw Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

NSCLC patients suitable for neoadjuvant therapy

Description

Inclusion Criteria:

  1. pathologically diagnosed non-small cell lung cancer
  2. The treatment plan is：receiving neoadjuvant chemo-immunotherapy during the study period, followed by surgical resection

Exclusion Criteria:

  1. recurrent or metastatic lung cancer;
  2. patients with other primary tumors

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
NSCLC with neoadjuvant therapy but without surgery
NSCLC with neoadjuvant therapy and surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
pathologic response
Time Frame: Perioperative
Perioperative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
EFS
Time Frame: One year after the treatment ended
event free survival
One year after the treatment ended

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Qian Chu

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

October 1, 2026

Study Registration Dates

First Submitted

January 28, 2026

First Submitted That Met QC Criteria

February 4, 2026

First Posted (Actual)

February 5, 2026

Study Record Updates

Last Update Posted (Actual)

March 19, 2026

Last Update Submitted That Met QC Criteria

March 18, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • TJ-IRB202512147

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Due to patient and hospital ethical requirements, this project does not currently meet the criteria for Individual Patient Data (IPD).

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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