Partial Wrist Denervation in Comminuted Articular Distal Radius Fractures

the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture

Study Overview

• Status: Active, not recruiting
• Conditions: Parial Denervation; Fracture Disatl Radius
• Intervention / Treatment: Procedure: Partial Wrist Denervation in Comminuted articular Distal Radius Fractures

Detailed Description

Distal radius fractures represent the most common fractures in adults showing an overall prevalence of 17.5 % with respect to all fractures. partial wrist denervation is an adjunctive procedure performed during initial fracture fixation to mitigate chronic pain by interrupting sensory innervation to the wrist joint. It targets the anterior interosseous nerve (AIN) and posterior interosseous nerve (PIN), which convey nociceptive signals from the radiocarpal and midcarpal joints.

Comminuted intra-articular distal radius fractures (AO/OTA Type C2/C3) often lead to post-traumatic arthritis due to articular incongruity and capsular damage. Denervation at the index procedure may reduce central sensitization and chronic pain by resecting afferent pain fibers, potentially improving postoperative rehabilitation and functional outcomes.

Acute comminuted intra-articular distal radius fractures (AO/OTA C2/C3) with high risk of post-traumatic arthritis (e.g., articular step-off >2 mm, severe fragmentation).

• Active individuals seeking motion preservation, those with high functional demands (e.g., athletes, laborers), or patients preferring a less invasive option than salvage procedures.
• Adjunct to primary fixation: Performed concurrently with volar locking plate (VLP) or dorsal plating.

• Study Type: Interventional
• Enrollment (Actual): 56
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Asyut, Egypt, 22222
    • Assiut Universty

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:• Age from 18

• Fracture Pattern: Acute, comminuted intra-articular distal radius fractures (AO/OTA Type C2 or C3).
• Surgical Context: Procedure performed as a primary adjunct during initial open reduction and internal fixation (ORIF).

Exclusion Criteria:Active local infection over the surgical site.

• Compromised soft tissue envelope that precludes safe dissection.
• Vascular injury or compromise requiring repair.
• Pre-existing neurological deficit (e.g., complex regional pain syndrome, major peripheral nerve injury).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: parital wrist denervation; Partial Wrist Denervation in Comminuted articular Distal Radius Fractures	Procedure: Partial Wrist Denervation in Comminuted articular Distal Radius Fractures; Partial Wrist Denervation in Comminuted articular Distal Radius Fractures through sme approach of the surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The end results PAIN will be assessed according to mayo clinc wrist score	mayo clinc wrist score its a clincal reported outcome measure designed to assess function and pain of the wrist follwing surgery the score is bassed on 100 points divided into four equally weighted categories the final score places the wrist into outcome category total score 90/100 is excellent while below 65 is poor	2 weeks, 6 weeks, 3 months, 6 months..and 1 year

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Study Director: walyd ryad saleh, professor of orthopedics, Assiut University

Publications and helpful links

Helpful Links

• Related Info

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027

Study Registration Dates

• First Submitted: January 22, 2026
• First Submitted That Met QC Criteria: January 30, 2026
• First Posted (Actual): February 6, 2026

Study Record Updates

• Last Update Posted (Actual): February 6, 2026
• Last Update Submitted That Met QC Criteria: January 30, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Keywords: parital denervation; comminuted distal radius fractures; chronic wrist pain
• Other Study ID Numbers: denervation in fracture radius

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: will wait till we see the result

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No