Comparison of the Metabolomic Effects of Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy

February 20, 2026 updated by: Ahmet Atlas, Harran University
Analytical techniques used in metabolomic studies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The study will involve comparing the metabolomic profiles of patients receiving sevoflurane and desflurane during surgery to identify any differences in metabolic pathways affected by the two anaesthetic techniques. Metabolomic profiles are generated using spectroscopic and spectrometric techniques such as high-field NMR and MS, as well as separation techniques.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Our study will include 100 patients undergoing laparoscopic cholecystectomy surgery, divided into two groups. Patients aged 18-65 years with an ASA I-II classification, who will undergo laparoscopic cholecystectomy surgery, have no active infection, and have a body mass index (BMI) <35, and who agree to participate in the study, will be intubated after standard anaesthetic induction (propofol, rocuronium, fentanyl) and intubated. The first sample will be taken from the finger immediately after the inhalation anaesthetic (sevoflurane, desflurane) reaches 1 minimal alveolar concentration (MAC) level. The second sample will be taken after the surgical procedure is completed and the inhalation anaesthesia is discontinued. The samples will be taken from the patients' fingertips and absorbed onto Guthrie paper. Statistical analysis will be performed on the data obtained.

Study Type

Interventional

Enrollment (Estimated)

80

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients undergoing laparoscopic cholecystectomy surgery who have no active infection, Body mass index (BMI)<35, Aged 18-65, ASA I-II, and who agree to participate in the study

Exclusion Criteria:

  • Individuals over 65 years of age ASA 3-4 patients Individuals with a body mass index (BMI) >35 Smokers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: sevoflurane group
Procedure: Sevoflurane
This group will be operated on under sevoflurane.
Active Comparator: desflurane group
Procedure: Desflurane
This group will be operated on under desflurane.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
amino acid metabolism
Time Frame: 12 weeks
12 weeks
Our primary outcome measure will be the effect of both inhalation anaesthetics on amino acid metabolism.
Time Frame: 12 weeks
12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Harran University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 1, 2026

Primary Completion (Estimated)

May 15, 2026

Study Completion (Estimated)

May 30, 2026

Study Registration Dates

First Submitted

January 5, 2026

First Submitted That Met QC Criteria

February 2, 2026

First Posted (Actual)

February 10, 2026

Study Record Updates

Last Update Posted (Actual)

February 23, 2026

Last Update Submitted That Met QC Criteria

February 20, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • hru/25.05.05

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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