Hyaluronic Acid and Amino Acid Combination Versus Exercise for Chronic Lateral Epicondylitis

February 7, 2026 updated by: Serkan Polat, Sivas State Hospital

A New Era in the Treatment of Chronic Lateral Epicondylitis: Comparison of Targeted Biological Support Using a Hyaluronic Acid and Amino Acid Combination Versus Exercise Therapy: A Retrospective, Controlled Clinical Study

This retrospective, controlled clinical study aims to evaluate the effectiveness of a targeted biological support injection containing a hyaluronic acid and amino acid combination in patients with chronic lateral epicondylitis (tennis elbow). Medical records will be reviewed to compare outcomes between patients treated in routine clinical practice with a 3-dose injection regimen (weeks 0, 2, and 4) plus a home exercise program and those treated with a home exercise program alone. Key outcome measures include pain intensity (VAS), functional status (PRTEE), grip strength, and pressure pain threshold.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients diagnosed with chronic Lateral Epicondylitis who applied to the Physical Medicine and Rehabilitation outpatient clinic of Sivas State Hospital. The study involves the retrospective analysis of patients treated between June 01, 2025, and November 01, 2025.

Description

Inclusion Criteria:

  • Patients aged between 18 and 70 years.
  • Patients diagnosed with Lateral Epicondylitis (LE).
  • Presence of symptoms persisting for 6 weeks or longer.
  • Patients who were treated with either a 3-dose protocol of Hyaluronic Acid + Amino Acid injection combined with a home exercise program, or a home exercise program alone.

Exclusion Criteria:

  • History of rheumatic disease.
  • History of malignancy.
  • Presence of radiculopathy or neuropathy.
  • Presence of peripheral circulatory disorders.
  • Congenital or acquired upper extremity deformities.
  • History of coagulopathy or current use of warfarin therapy.
  • Presence of prosthesis, metal implant, or internal fixator in the elbow region.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Control Group: Home Exercise Program Only
Home exercise program without injection.
Behavioral: Home Exercise Program
Standardized home exercise program for chronic lateral epicondylitis.
Intervention Group: HA+AA Injection + Home Exercise Program
Patients in this retrospective cohort were treated with a targeted biological support injection (Hyaluronic Acid and Amino Acid combination) administered at weeks 0, 2, and 4, in addition to the standardized home exercise program.
Behavioral: Home Exercise Program
Standardized home exercise program for chronic lateral epicondylitis.
Drug: Hyaluronic Acid + Amino Acid Injection
3-dose injection protocol administered at weeks 0, 2, and 4.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Pain Intensity (VAS)
Time Frame: Baseline, Week 4, and Month 3
Pain intensity will be measured using a 10-cm Visual Analog Scale (VAS).
Baseline, Week 4, and Month 3

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Pressure Pain Threshold (Algometry)
Time Frame: Baseline, Week 4, and Month 3
Pressure pain threshold over the common extensor tendon will be measured using a handheld algometer.
Baseline, Week 4, and Month 3
Change in Functional Status (PRTEE Score)
Time Frame: Baseline, Week 4, and Month 3
Functional disability and pain will be assessed using the Patient-Rated Tennis Elbow Evaluation (PRTEE).
Baseline, Week 4, and Month 3
Change in Grip Strength (Hand Dynamometer)
Time Frame: Baseline, Week 4, and Month 3
Grip strength will be measured using a hand-held dynamometer. Measurements will be recorded in kilograms (kg). Higher values indicate greater strength.
Baseline, Week 4, and Month 3

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sivas State Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2025

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

May 1, 2026

Study Registration Dates

First Submitted

February 7, 2026

First Submitted That Met QC Criteria

February 7, 2026

First Posted (Actual)

February 13, 2026

Study Record Updates

Last Update Posted (Actual)

February 13, 2026

Last Update Submitted That Met QC Criteria

February 7, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • HA+AA-LE-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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