Mastication, Cognition, and Nutritional Status in Multiple Sclerosis

February 9, 2026 updated by: Seda Nur Kemer, Ondokuz Mayıs University

Investigation of the Relationship Between Chewing Function and Cognitive Functions, Disease Severity, and Nutritional Status in Individuals With Multiple Sclerosis

The aim of this study is to investigate the relationship between chewing function and cognitive functions, disease severity, and nutritional status in individuals diagnosed with Multiple Sclerosis

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

86

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

The study population will consist of individuals aged 18 years and older diagnosed with Multiple Sclerosis who are followed up at the neurology outpatient clinics.

Description

Inclusion Criteria:

  • Being 18 years of age or older

Exclusion Criteria:

  • Having a neurological or systemic disease other than Multiple Sclerosis that may affect chewing function
  • Inability to provide adequate communication or cooperation due to psychiatric disorders
  • Not being diagnosed with Multiple Sclerosis
  • Not volunteering to participate in the study
  • Presence of severe problems preventing questionnaire administration (visual and/or hearing impairments)
  • History or presence of psychiatric and/or other neurological disorders
  • Presence of severe neurological findings that may negatively affect cognitive performance (e.g., severe optic neuritis)
  • Use of medications affecting cognitive functions
  • Alcohol or substance use
  • Having experienced a relapse within the last month
  • Having received corticosteroid treatment within the last month
  • History of stroke, head and neck cancer, or rheumatic diseases that may affect swallowing and chewing performance

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Multiple Sclerosis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Expanded Disability Status Scale (EDSS)
Time Frame: Baseline
Baseline
Montreal Cognitive Assessment (MoCA)
Time Frame: Baseline
Baseline
Turkish version of the Eating Assessment Scale (T-EAT-10)
Time Frame: Baseline
Baseline
Dysphagia in Multiple Sclerosis (DYMUS)
Time Frame: Baseline
Baseline
Test of Masticating and Swallowing Solids (TOMASS)
Time Frame: Baseline
Baseline
Mini Nutritional Assessment Short Form (MNA)
Time Frame: Baseline
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ondokuz Mayıs University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

March 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

February 9, 2026

First Submitted That Met QC Criteria

February 9, 2026

First Posted (Actual)

February 17, 2026

Study Record Updates

Last Update Posted (Actual)

February 17, 2026

Last Update Submitted That Met QC Criteria

February 9, 2026

Last Verified

July 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2025/283

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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