PPV vs PVI in the Supine and Prone Position

February 10, 2026 updated by: Joseph D. Tobias

Variability and Correlation of the Pulse Pressure Variability (PPV) and the Plethysmography Variability Index (PVI) in the Supine and Prone Position

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol.

The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients undergoing surgery at Nationwide Children's Hospital only.

Description

Inclusion Criteria:

  • Consenting ASA 1-4 patients
  • Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning

Exclusion Criteria:

  • Patients in whom an arterial cannula is not indicated or cannot be placed
  • Patients undergoing a surgical procedure that does not require prone positioning

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Prone surgical patients
Other: Observation
No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
PPV Supine
Time Frame: Once a minute for 5 minutes
Pulse Pressure Variability (PPV) recorded from the arterial line while supine.
Once a minute for 5 minutes
PVI Supine
Time Frame: Once a minute for 5 minutes
Plethysmography Variability Index (PVI) recorded from the pulse oximeter while supine.
Once a minute for 5 minutes
PPV Prone
Time Frame: Once a minute for 5 minutes
Pulse Pressure Variability (PPV) recorded from the arterial line while prone.
Once a minute for 5 minutes
PVI Prone
Time Frame: Once a minute for 5 minutes
Plethysmography Variability Index (PVI) recorded from the pulse oximeter while prone.
Once a minute for 5 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Joseph D. Tobias

Investigators

  • Principal Investigator: Joseph Tobias, MD, Nationwide Children's Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

May 31, 2029

Study Completion (Estimated)

May 31, 2029

Study Registration Dates

First Submitted

February 10, 2026

First Submitted That Met QC Criteria

February 10, 2026

First Posted (Actual)

February 17, 2026

Study Record Updates

Last Update Posted (Actual)

February 17, 2026

Last Update Submitted That Met QC Criteria

February 10, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • STUDY00005745

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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